PMID- 36537043
OWN - NLM
STAT- MEDLINE
DCOM- 20230316
LR  - 20230316
IS  - 1553-3840 (Electronic)
IS  - 1553-3840 (Linking)
VI  - 20
IP  - 1
DP  - 2023 Mar 1
TI  - Psychobiotic interventions attenuate chronic alcohol use-mediated exacerbation of 
      posttraumatic stress disorder in rats: the role of gut-liver axis response.
PG  - 92-105
LID - 10.1515/jcim-2022-0353 [doi]
AB  - OBJECTIVES: The incidence of co-occurring alcohol-use disorder (AUD) and 
      post-traumatic stress disorder (PTSD) is high, and the presence of one disorder 
      aggravates the severity of the other. Emerging evidence shows the neuroprotective 
      and anti-inflammation functions of psychobiotics. Hence, the study explored the 
      effects of probiotics and synbiotic inulin on the gut- and liver-oxidative and 
      inflammatory biomarkers in chronic alcohol exacerbation of PTSD symptoms in rats. 
      METHODS: Young adult rats were administered 10% ethanol in a two-bottle choice 
      test for six weeks and were subjected to single prolonged stress. Probiotics 
      and synbiotic intervention followed this. Markers of oxido-inflammatory stress, 
      liver functions, intestinal (faecal) metabolites, occludin expression, and 
      histopathology of the ileum and liver were evaluated. RESULTS: Chronic alcohol 
      drinking and PTSD increased oxido-inflammatory stress, markers of hepatic damage, 
      and reduced faecal metabolites, which were attenuated by probiotic and synbiotic 
      interventions. Furthermore, reduced immunoexpression of gut and liver occludin, 
      with loss of barrier integrity, viable hepatocytes, congestive portal area, and 
      shortened villi and crypt depth, were observed. Probiotic and synbiotic 
      interventions mitigated these effects. CONCLUSIONS: The study demonstrates that 
      psychobiotics mitigate the detrimental effects of co-occurring chronic alcohol 
      intake in the context of PTSD.
CI  - (c) 2022 Walter de Gruyter GmbH, Berlin/Boston.
FAU - Akinluyi, Elizabeth T
AU  - Akinluyi ET
AD  - Neuropharmacology Unit, Department of Pharmacology and Therapeutics, College of 
      Medicine and Health Sciences, Afe Babalola University, Ado- Ekiti, Nigeria.
FAU - Edem, Edem E
AU  - Edem EE
AD  - Neuroscience Unit, Department of Human Anatomy, College of Medicine and Health 
      Sciences, Afe Babalola University, Ado- Ekiti, Nigeria.
FAU - Dakoru, Kelvin M
AU  - Dakoru KM
AD  - Neuropharmacology Unit, Department of Pharmacology and Therapeutics, College of 
      Medicine and Health Sciences, Afe Babalola University, Ado- Ekiti, Nigeria.
FAU - Nnodim, Chinaza J
AU  - Nnodim CJ
AD  - Neuropharmacology Unit, Department of Pharmacology and Therapeutics, College of 
      Medicine and Health Sciences, Afe Babalola University, Ado- Ekiti, Nigeria.
FAU - Oladipupo, Michael A
AU  - Oladipupo MA
AD  - Neuropharmacology Unit, Department of Pharmacology and Therapeutics, College of 
      Medicine and Health Sciences, Afe Babalola University, Ado- Ekiti, Nigeria.
FAU - Adeoluwa, Olusegun A
AU  - Adeoluwa OA
AD  - Neuropharmacology Unit, Department of Pharmacology and Therapeutics, College of 
      Medicine and Health Sciences, Afe Babalola University, Ado- Ekiti, Nigeria.
FAU - Obisesan, Abiola O
AU  - Obisesan AO
AD  - Department of Pharmaceutical Microbiology, College of Pharmacy, Afe Babalola 
      University, Ado-Ekiti, Nigeria.
FAU - Ben-Azu, Benneth
AU  - Ben-Azu B
AD  - Department of Pharmacology and Therapeutics, Faculty of Basic Medical Sciences, 
      College of Health Sciences, Delta State University, Abraka, Delta State, Nigeria.
FAU - Adebayo, Olusegun G
AU  - Adebayo OG
AD  - Neurophysiology Unit, Department of Physiology, Faculty of Basic Medical 
      Sciences, PAMO University of Medical Sciences, Port Harcourt, Rivers State, 
      Nigeria.
LA  - eng
PT  - Journal Article
DEP - 20221221
PL  - Germany
TA  - J Complement Integr Med
JT  - Journal of complementary & integrative medicine
JID - 101313855
RN  - 0 (Occludin)
RN  - 3K9958V90M (Ethanol)
SB  - IM
MH  - Rats
MH  - Animals
MH  - *Stress Disorders, Post-Traumatic/therapy
MH  - Occludin
MH  - Liver
MH  - *Probiotics/therapeutic use/pharmacology
MH  - Ethanol
MH  - Alcohol Drinking
OTO - NOTNLM
OT  - alcohol-use disorder
OT  - gut-liver axis
OT  - oxidative stress
OT  - post-traumatic stress disorder
OT  - probiotics
OT  - synbiotic
EDAT- 2022/12/21 06:00
MHDA- 2023/03/17 06:00
CRDT- 2022/12/20 02:34
PHST- 2022/09/29 00:00 [received]
PHST- 2022/11/29 00:00 [accepted]
PHST- 2022/12/21 06:00 [pubmed]
PHST- 2023/03/17 06:00 [medline]
PHST- 2022/12/20 02:34 [entrez]
AID - jcim-2022-0353 [pii]
AID - 10.1515/jcim-2022-0353 [doi]
PST - epublish
SO  - J Complement Integr Med. 2022 Dec 21;20(1):92-105. doi: 10.1515/jcim-2022-0353. 
      eCollection 2023 Mar 1.