PMID- 36537417
OWN - NLM
STAT- MEDLINE
DCOM- 20221221
LR  - 20221222
IS  - 1998-4022 (Electronic)
IS  - 0028-3886 (Linking)
VI  - 70
IP  - 6
DP  - 2022 Nov-Dec
TI  - Can Lamina Cribrosa Indicate Optic Neuritis in Multiple Sclerosis?
PG  - 2366-2370
LID - 10.4103/0028-3886.364057 [doi]
AB  - BACKGROUND: In this study, we aimed to evaluate the association of lamina 
      cribrosa thickness (LCT) and lamina cribrosa depth (LCD), as determined by 
      spectral domain optical coherence tomography (SD-OCT), with visual evoked 
      potentials (VEPs) in patients with multiple sclerosis (MS). MATERIALS AND 
      METHODS: Patients enrolled in this prospective, cross-sectional study were 
      divided into three groups. Group 1 consisted of 25 relapsing-remitting MS 
      patients with VEP pathology in one or both eyes. In patients with VEP pathology 
      in both eyes, one eye was chosen randomly. Group 2 comprised 25 
      relapsing-remitting MS patients with no VEP pathology or optic neuritis history. 
      A randomly selected single eye of each patient was evaluated. Group 3 consisted 
      of 25 age- and sex-matched healthy volunteers; a randomly selected single eye of 
      these participants was examined. LCT, LCD, and retinal nerve fiber layer (RNFL) 
      thickness measurements were determined in four quadrants (superior, inferior, 
      nasal, and temporal) by SD-OCT. RESULTS: The three groups were similar in terms 
      of age and sex. The mean LCT was lower in Group 1 than in Group 2, but the 
      difference was not statistically significant (268.80 +/- 36.69 mum [min-max = 
      222-394 mum] versus 285.80 +/- 12.00 mum [min-max = 249-338 mum]; P = 0.148). The mean 
      LCT was significantly lower in Group 1 than in Group 3 (268.80 +/- 36.69 mum 
      [min-max = 222-394 mum] versus 294.80 +/- 12.00 mum [min-max = 232-351 mum]; P = 
      0.012). There was a weak positive correlation between LCT and RNFL-inferior, 
      RNFL-nasal, and RNFL-temporal. CONCLUSION: We found that the lamina cribrosa was 
      thinner in MS patients with VEP pathology. To the best of our knowledge, this is 
      a novel finding. Our results imply that LCT could be used as an indicator of 
      optic neuritis in MS patients.
FAU - Hamamci, Mehmet
AU  - Hamamci M
AD  - Department of Neurology, Bozok University, Faculty of Medicine, Yozgat, Turkey.
FAU - Kucuk, Bekir
AU  - Kucuk B
AD  - Department of Ophthalmology, Bozok University, Faculty of Medicine, Yozgat, 
      Turkey.
FAU - Bayhan, Seray A
AU  - Bayhan SA
AD  - Department of Ophthalmology, Bozok University, Faculty of Medicine, Yozgat, 
      Turkey.
FAU - Bayhan, Hasan A
AU  - Bayhan HA
AD  - Department of Ophthalmology, Bozok University, Faculty of Medicine, Yozgat, 
      Turkey.
FAU - Inan, Levent E
AU  - Inan LE
AD  - Department of Neurology, Bozok University, Faculty of Medicine, Yozgat, Turkey.
LA  - eng
PT  - Journal Article
PL  - India
TA  - Neurol India
JT  - Neurology India
JID - 0042005
SB  - IM
MH  - Humans
MH  - *Multiple Sclerosis/pathology
MH  - Cross-Sectional Studies
MH  - Evoked Potentials, Visual
MH  - Prospective Studies
MH  - Retina/pathology
MH  - *Optic Neuritis
MH  - *Multiple Sclerosis, Relapsing-Remitting/pathology
MH  - Tomography, Optical Coherence/methods
OTO - NOTNLM
OT  - Optical coherence tomography
OT  - retinal nerve fiber thickness
OT  - visual evoked potentials
COIS- None
EDAT- 2022/12/21 06:00
MHDA- 2022/12/22 06:00
CRDT- 2022/12/20 06:14
PHST- 2022/12/20 06:14 [entrez]
PHST- 2022/12/21 06:00 [pubmed]
PHST- 2022/12/22 06:00 [medline]
AID - ni_2022_70_6_2366_364057 [pii]
AID - 10.4103/0028-3886.364057 [doi]
PST - ppublish
SO  - Neurol India. 2022 Nov-Dec;70(6):2366-2370. doi: 10.4103/0028-3886.364057.