PMID- 36538227
OWN - NLM
STAT- MEDLINE
DCOM- 20230329
LR  - 20230329
IS  - 1614-7499 (Electronic)
IS  - 0944-1344 (Linking)
VI  - 30
IP  - 13
DP  - 2023 Mar
TI  - Association of human cohorts exposed to blood and urinary biomarkers of PAHs with 
      adult asthma in a South Asian metropolitan city.
PG  - 35945-35957
LID - 10.1007/s11356-022-24445-z [doi]
AB  - Semi-volatile organic compounds (SVOCs) are a major global problem that causes 
      the greatest impact on urban settings and have been linked to bronchial asthma in 
      both children and adults in Pakistan. The association between exposure of 
      polycyclic aromatic hydrocarbons (PAHs) and asthma in the adult population is 
      less clear. The current study aimed to assess the clinico-chemical parameters and 
      blood levels of naphthalene phenanthrene, pyrene, and 1,2-benzanthracene and 
      urinary levels of 1-OH pyrene and 1-OH phenanthrene as well as asthma-related 
      biomarkers immunoglobulin E (IgE), resistin, and superoxide dismutase (SOD) of 
      oxidative stress and other hematologic parameters in adults and their 
      relationship with bronchial asthma. The GC/MS analysis showed higher mean 
      concentrations of blood PAHs in asthma respondents (4.48 +/- 1.34, 3.46 +/- 1.04, 
      0.10 +/- 0.03, and 0.29 +/- 0.09) (ng/mL) as compared to controls (3.07 +/- 0.92, 
      1.71 +/- 0.51, 0.06 +/- 0.02, and 0.11 +/- 0.03) (ng/mL), with p = .006, p = .001, 
      p = .050, and p = .001. Similarly, urinary levels of 1-OHpyr and 1-OHphe were 
      significantly increased in adults with bronchial asthma (0.54 +/- 0.16; 
      0.13 +/- 0.04) (mumol/mol-Cr) than in controls (0.30 +/- 0.09; 0.05 +/- 0.02) 
      (mumol/mol-Cr), with p = .002 and p = .0001, respectively, with a significant 
      positive correlation to asthma severity. The asthma-related biomarkers IgE, 
      resistin, and SOD were significantly higher (p 0.0001, 0.0001, and 0.0001) in 
      people with asthma than in control persons. The findings showed that higher blood 
      and urine PAHs levels were linked to higher asthma risk in adults and significant 
      interaction with participants who smoked, had allergies, had a family history of 
      asthma, and were exposed to dust. The current study's findings will be useful to 
      local regulatory agencies in Lahore in terms of managing exposure and advocating 
      efforts to minimize PAH pollution and manage health.
CI  - (c) 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, 
      part of Springer Nature.
FAU - Aslam, Rabia
AU  - Aslam R
AD  - Sustainable Development Study Centre (SDSC), Government College University, 
      Lahore, 54000, Pakistan. rabia.irfan8@gmail.com.
FAU - Sharif, Faiza
AU  - Sharif F
AD  - Sustainable Development Study Centre (SDSC), Government College University, 
      Lahore, 54000, Pakistan.
FAU - Baqar, Mujtaba
AU  - Baqar M
AD  - Sustainable Development Study Centre (SDSC), Government College University, 
      Lahore, 54000, Pakistan. mujtababaqar@gcu.edu.pk.
FAU - Nizami, Abdul-Sattar
AU  - Nizami AS
AD  - Sustainable Development Study Centre (SDSC), Government College University, 
      Lahore, 54000, Pakistan.
LA  - eng
PT  - Journal Article
DEP - 20221220
PL  - Germany
TA  - Environ Sci Pollut Res Int
JT  - Environmental science and pollution research international
JID - 9441769
RN  - 0 (Polycyclic Aromatic Hydrocarbons)
RN  - 0 (Resistin)
RN  - 0 (Pyrenes)
RN  - 0 (Biomarkers)
RN  - 0 (Phenanthrenes)
RN  - EC 1.15.1.1 (Superoxide Dismutase)
SB  - IM
MH  - Child
MH  - Humans
MH  - Adult
MH  - *Polycyclic Aromatic Hydrocarbons/analysis
MH  - Resistin
MH  - Pyrenes
MH  - Biomarkers
MH  - *Asthma/epidemiology
MH  - *Phenanthrenes
MH  - Superoxide Dismutase
OTO - NOTNLM
OT  - Bronchial asthma
OT  - Immunoglobulin E
OT  - Oxidative stress
OT  - Polycyclic aromatic hydrocarbons
OT  - Semi-volatile organic compounds
OT  - Superoxide dismutase
EDAT- 2022/12/21 06:00
MHDA- 2023/03/29 06:05
CRDT- 2022/12/20 11:19
PHST- 2022/04/04 00:00 [received]
PHST- 2022/11/24 00:00 [accepted]
PHST- 2023/03/29 06:05 [medline]
PHST- 2022/12/21 06:00 [pubmed]
PHST- 2022/12/20 11:19 [entrez]
AID - 10.1007/s11356-022-24445-z [pii]
AID - 10.1007/s11356-022-24445-z [doi]
PST - ppublish
SO  - Environ Sci Pollut Res Int. 2023 Mar;30(13):35945-35957. doi: 
      10.1007/s11356-022-24445-z. Epub 2022 Dec 20.