PMID- 36538727
OWN - NLM
STAT- MEDLINE
DCOM- 20230418
LR  - 20230424
IS  - 2192-2659 (Electronic)
IS  - 2192-2640 (Linking)
VI  - 12
IP  - 10
DP  - 2023 Apr
TI  - Drug Self-Delivery Systems: Molecule Design, Construction Strategy, and 
      Biological Application.
PG  - e2202769
LID - 10.1002/adhm.202202769 [doi]
AB  - Drug self-delivery systems (DSDSs) offer new ways to create novel drug delivery 
      systems (DDSs). In typical DSDSs, therapeutic reagents are not considered passive 
      cargos but active delivery agents of actionable targets. As an advanced drug 
      delivery strategy, DSDSs with positive cooperativity of both free drugs and 
      nanocarriers exhibit the clear merits of unprecedented drug-loading capacity, 
      minimized systemic toxicity, and flexible preparation of nanoscale deliverables 
      for passive targeted therapy. This review highlights the recent advances and 
      future trends in DSDSs on the basis of two differently constructed structures: 
      covalent and noncovalent bond-based DSDSs. Specifically, various chemical and 
      architectural designs, fabrication strategies, and responsive and functional 
      features are comprehensively discussed for these two types of DSDSs. In addition, 
      additional comments on the current development status of DSDSs and the potential 
      applications of their molecular designs are presented in the corresponding 
      discussion. Finally, the promising potential of DSDSs in biological applications 
      is revealed and the relationship between preliminary molecular design of DSDSs 
      and therapeutic effects of subsequent DSDSs biological applications is clarified.
CI  - (c) 2023 Wiley-VCH GmbH.
FAU - Liu, Chengfei
AU  - Liu C
AD  - Shaanxi Key Laboratory of Macromolecular Science and Technology, MOE Key 
      Laboratory of Material Physics and Chemistry under Extraordinary Conditions, 
      School of Chemistry and Chemical Engineering, Northwestern Polytechnical 
      University, Xi'an, Shaanxi, 710072, China.
FAU - Liu, Caiping
AU  - Liu C
AD  - Shaanxi Key Laboratory of Chemical Additives for Industry, College of Chemistry 
      and Chemical Engineering, Shaanxi University of Science and Technology, Xi'an, 
      Shaanxi, 710021, China.
FAU - Bai, Yang
AU  - Bai Y
AD  - Shaanxi Key Laboratory of Chemical Additives for Industry, College of Chemistry 
      and Chemical Engineering, Shaanxi University of Science and Technology, Xi'an, 
      Shaanxi, 710021, China.
FAU - Wang, Jingxia
AU  - Wang J
AD  - Shaanxi Key Laboratory of Macromolecular Science and Technology, MOE Key 
      Laboratory of Material Physics and Chemistry under Extraordinary Conditions, 
      School of Chemistry and Chemical Engineering, Northwestern Polytechnical 
      University, Xi'an, Shaanxi, 710072, China.
FAU - Tian, Wei
AU  - Tian W
AUID- ORCID: 0000-0002-2159-4181
AD  - Shaanxi Key Laboratory of Macromolecular Science and Technology, MOE Key 
      Laboratory of Material Physics and Chemistry under Extraordinary Conditions, 
      School of Chemistry and Chemical Engineering, Northwestern Polytechnical 
      University, Xi'an, Shaanxi, 710072, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20230130
PL  - Germany
TA  - Adv Healthc Mater
JT  - Advanced healthcare materials
JID - 101581613
SB  - IM
MH  - *Drug Delivery Systems
OTO - NOTNLM
OT  - covalent bond
OT  - drug self-delivery
OT  - supramolecular interaction
EDAT- 2022/12/21 06:00
MHDA- 2023/04/18 06:42
CRDT- 2022/12/20 15:43
PHST- 2022/11/29 00:00 [revised]
PHST- 2022/10/27 00:00 [received]
PHST- 2023/04/18 06:42 [medline]
PHST- 2022/12/21 06:00 [pubmed]
PHST- 2022/12/20 15:43 [entrez]
AID - 10.1002/adhm.202202769 [doi]
PST - ppublish
SO  - Adv Healthc Mater. 2023 Apr;12(10):e2202769. doi: 10.1002/adhm.202202769. Epub 
      2023 Jan 30.