PMID- 36539134
OWN - NLM
STAT- MEDLINE
DCOM- 20221222
LR  - 20221222
IS  - 1512-0112 (Print)
IS  - 1512-0112 (Linking)
IP  - 331
DP  - 2022 Oct
TI  - HOMOCYSTEINE LEVEL IN PATIENTS WITH POLYCYSTIC OVARY SYNDROME WITH AND WITHOUT 
      INSULIN RESISTANCE.
PG  - 72-77
AB  - Until recent period, hyperinsulinemia and hyperandrogenism were thought to be 
      involved in the pathogenesis of polycystic ovary syndrome (PCOS), however, in 
      recent years several studies reported that hyperhomocysteinemia, which may be 
      associated with insulin resistance, plays important role in the pathogenesis of 
      PCOS. Therefore, hyperhomocysteinemia (HHcy) can be considered as one of the 
      newly identified characteristics of PCOS. The aim of the study was to evaluate 
      homocysteine (Hcy) levels in patients with PCOS with and without insulin 
      resistance. The study was conducted in 59 patients with PCOS aged 13-35 (mean age 
      24.5+/-3.5). Patients were divided into 2 groups: Group I - 38 patients with PCOS 
      and insulin resistance, Group II - 21 patients with PCOS without insulin 
      resistance. PCOS patients as well were divided into 3 subgroups according to 
      homocysteine values: low - </= 6.09 mumol/l, moderate - 6.10-9.33 mumol/l, high >9.34 
      mumol/l). In patients with PCOS and insulin resistance were established a 
      significant increase in homocysteine levels, HOMA-IR and BMI indicators compared 
      to those patients with PCOS without insulin resistance. In the group of patients 
      with PCOS with insulin resistance homocysteine level with increased and high 
      normal level of homocysteine (high Hcy subgroup, >9.34 mumol/l) were significantly 
      more common (84.2%) compared to patients without insulin resistance (52%). 
      Homocysteine level is significantly elevated in patients with PCOS, and insulin 
      resistance compared to patients without insulin resistance. In the management of 
      patients with PCOS, along with correction of insulin resistance, control and 
      correction of homocysteine level should be considered, which will improve their 
      reproductive outcome.
FAU - Urjumelashvili, M
AU  - Urjumelashvili M
AD  - 1Iv. Javakhishvili Tbilisi State University, Faculty of Medicine, Department of 
      Obstetrics - Gynecology - Reproductology, Tbilisi, Georgia.
FAU - Kristesashvili, J
AU  - Kristesashvili J
AD  - 1Iv. Javakhishvili Tbilisi State University, Faculty of Medicine, Department of 
      Obstetrics - Gynecology - Reproductology, Tbilisi, Georgia.
FAU - Asanidze, E
AU  - Asanidze E
AD  - 2Faculty of Medicine at Teaching University Geomedi, Tbilisi, Georgia.
LA  - eng
PT  - Journal Article
PL  - Georgia (Republic)
TA  - Georgian Med News
JT  - Georgian medical news
JID - 101218222
RN  - 0LVT1QZ0BA (Homocysteine)
RN  - 0 (Insulin)
SB  - IM
MH  - Female
MH  - Humans
MH  - Young Adult
MH  - Adult
MH  - *Polycystic Ovary Syndrome/complications
MH  - *Insulin Resistance
MH  - *Hyperhomocysteinemia/complications
MH  - *Hyperinsulinism/complications
MH  - Homocysteine
MH  - Insulin
EDAT- 2022/12/21 06:00
MHDA- 2022/12/23 06:00
CRDT- 2022/12/20 19:15
PHST- 2022/12/20 19:15 [entrez]
PHST- 2022/12/21 06:00 [pubmed]
PHST- 2022/12/23 06:00 [medline]
PST - ppublish
SO  - Georgian Med News. 2022 Oct;(331):72-77.