PMID- 36539391
OWN - NLM
STAT- MEDLINE
DCOM- 20240201
LR  - 20240206
IS  - 1549-7828 (Electronic)
IS  - 1040-841X (Linking)
VI  - 50
IP  - 1
DP  - 2024 Feb
TI  - Insights into the molecular basis of c-di-GMP signalling in Pseudomonas 
      aeruginosa.
PG  - 20-38
LID - 10.1080/1040841X.2022.2154140 [doi]
AB  - The opportunistic human pathogen Pseudomonas aeruginosa can cause severe 
      infections in immunocompromized people or cystic fibrosis (CF) patients. Because 
      of its remarkable ability to invade the host and withstand the bacteriocidal 
      effect of most conventional antibiotics, the infection caused by P. aeruginosa 
      has become a major concern for human health. The switch from acute to chronic 
      infection is governed by the second messenger bis-(3'-5')-cyclic dimeric 
      guanosine mono-phosphate (c-di-GMP) in P. aeruginosa, and c-di-GMP is now 
      recognized to regulate many important biological processes in pathogenesis. The 
      c-di-GMP signalling mechanisms in P. aeruginosa have been studied extensively in 
      the past decade, revealing complicated c-di-GMP metabolism and signalling 
      network. In this review, the underlying mechanisms of this signalling network 
      will be discussed, mainly focussing on how environmental cues regulate c-di-GMP 
      signalling, protein-protein interaction mediated functional regulation, 
      heterogeneity of c-di-GMP and cross talk between c-di-GMP signalling and other 
      signalling systems. Understanding the molecular mechanism underlying the complex 
      c-di-GMP signalling network would be beneficial for developing therapeutic 
      approaches and antibacterial agents to combat the threat from P. aeruginosa.
FAU - Feng, Qishun
AU  - Feng Q
AD  - School of Medicine, Southern University of Science and Technology, Shenzhen, PR 
      China.
FAU - Zhou, Jianuan
AU  - Zhou J
AD  - Guangdong Province Key Laboratory of Microbial Signals and Disease Control, 
      Integrative Microbiology Research Centre, South China Agricultural University, 
      Guangzhou, PR China.
AD  - Guangdong Laboratory for Lingnan Modern Agriculture, South China Agricultural 
      University, Guangzhou, PR China.
FAU - Zhang, Lianhui
AU  - Zhang L
AUID- ORCID: 0000-0002-1312-5086
AD  - Guangdong Province Key Laboratory of Microbial Signals and Disease Control, 
      Integrative Microbiology Research Centre, South China Agricultural University, 
      Guangzhou, PR China.
AD  - Guangdong Laboratory for Lingnan Modern Agriculture, South China Agricultural 
      University, Guangzhou, PR China.
FAU - Fu, Yang
AU  - Fu Y
AD  - School of Medicine, Southern University of Science and Technology, Shenzhen, PR 
      China.
FAU - Yang, Liang
AU  - Yang L
AUID- ORCID: 0000-0002-2362-0128
AD  - School of Medicine, Southern University of Science and Technology, Shenzhen, PR 
      China.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20221220
PL  - England
TA  - Crit Rev Microbiol
JT  - Critical reviews in microbiology
JID - 8914274
RN  - 0 (Bacterial Proteins)
RN  - 12133JR80S (Guanosine)
RN  - 61093-23-0 (bis(3',5')-cyclic diguanylic acid)
RN  - 0 (Phosphates)
RN  - H2D2X058MU (Cyclic GMP)
SB  - IM
MH  - Humans
MH  - *Bacterial Proteins/genetics/metabolism
MH  - *Pseudomonas aeruginosa/genetics
MH  - Guanosine/metabolism
MH  - Phosphates/metabolism
MH  - Biofilms
MH  - Gene Expression Regulation, Bacterial
MH  - Cyclic GMP/*analogs & derivatives
OTO - NOTNLM
OT  - Pseudomonas aeruginosa
OT  - c-di-GMP signalling
OT  - environmental cues
OT  - heterogeneity
OT  - protein-protein interaction
EDAT- 2022/12/21 06:00
MHDA- 2024/02/01 06:43
CRDT- 2022/12/20 23:13
PHST- 2024/02/01 06:43 [medline]
PHST- 2022/12/21 06:00 [pubmed]
PHST- 2022/12/20 23:13 [entrez]
AID - 10.1080/1040841X.2022.2154140 [doi]
PST - ppublish
SO  - Crit Rev Microbiol. 2024 Feb;50(1):20-38. doi: 10.1080/1040841X.2022.2154140. 
      Epub 2022 Dec 20.