PMID- 36540586
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230214
IS  - 1841-9038 (Print)
IS  - 2069-6116 (Electronic)
IS  - 1841-9038 (Linking)
VI  - 17
IP  - 3
DP  - 2022 Sep
TI  - Association of Serum Magnesium with Insulin Indices in Patients with Type 2 
      Diabetes Mellitus.
PG  - 596-601
LID - 10.26574/maedica.2022.17.3.596 [doi]
AB  - Introduction: Magnesium has a direct impact on glucose metabolism since it is a 
      cofactor for numerous energy-metabolizing enzymes. Hypomagnesemia has been linked 
      to poor glycemic control and a range of diabetes-related long-term complications. 
      This study aimed to assess the association between blood magnesium levels and 
      insulin sensitivity indices in patients with type 2 diabetes mellitus (T2DM). 
      Material and methods:Two hundred newly diagnosed T2DM patients aged over 40 years 
      were recruited after excluding those with a history of heart failure, kidney 
      illness, liver disease, hypothyroidism, ascites, pregnancy, tumors, and 
      complications such as diabetic ketoacidosis. Fasting glucose, serum magnesium, 
      serum insulin, serum urea and creatinine were measured. Patients were divided 
      into two groups based on their serum magnesium levels. Results:There were no age 
      or sex differences between the subjects of the two groups. Participants in the 
      group with low magnesium had significantly high fasting blood sugar (FBS), 
      postprandial blood sugar (PPBS), glycated hemoglobin (HbA1c), serum insulin, 
      homeostasis model assessment-estimated insulin resistance (HOMA-IR) (P < 0.001). 
      The multivariable logistic regression analysis showed significant associations 
      with PPBS [odds ratio (OR) 0.98 (95% CI 0.97-0.99)], HbA1c [OR 0.05 (95% 
      CI=0.005-0.55)] and creatinine [OR 0.004 (95% CI=0.00-0.074)]. Correlation 
      statistics showed a negative correlation between magnesium and PPBS (r =-0.204), 
      HOMA-IR (r = -0.819) and creatinine (r = -0.151). Conclusion:Serum magnesium 
      levels have a negative correlation with FBS and PPBS, as well as HOMA-IR. It may 
      well be essential to include serum magnesium level as a regular assessment in 
      patients with diabetes mellitus.
FAU - Kuppusamy, Santhanam
AU  - Kuppusamy S
AD  - Department of General Medicine, Government Villupuram Medical College, 
      Mundiyambakkam, Tamilnadu, India.
FAU - Dhanasinghu, Raju
AU  - Dhanasinghu R
AD  - Department of General Medicine, Government Villupuram Medical College, 
      Mundiyambakkam, Tamilnadu, India.
FAU - Sakthivadivel, Varatharajan
AU  - Sakthivadivel V
AD  - Department of General Medicine, All India Institute of Medical Sciences, 
      Bibinagar, Hyderabad, Telangana, India.
FAU - Kaliappan, Ariyanachi
AU  - Kaliappan A
AD  - Department of Anatomy, All India Institute of Medical Sciences, Bibinagar, 
      Hyderabad, Telangana, India.
FAU - Gaur, Archana
AU  - Gaur A
AD  - Department of Physiology, All India Institute of Medical Sciences, Bibinagar, 
      Hyderabad, Telangana, India.
FAU - Balan, Yuvaraj
AU  - Balan Y
AD  - Department of Biochemistry, All India Institute of Medical Sciences, Bibinagar, 
      Hyderabad, Telangana, India.
FAU - Tadi, Lakshmi Jyothi
AU  - Tadi LJ
AD  - Department of Microbiology, All India Institute of Medical Sciences, Bibinagar, 
      Hyderabad, Telangana, India.
FAU - Sundaramurthy, Raja
AU  - Sundaramurthy R
AD  - Department of Microbiology, All India Institute of Medical Sciences, Bibinagar, 
      Hyderabad, Telangana, India.
LA  - eng
PT  - Editorial
PL  - Romania
TA  - Maedica (Bucur)
JT  - Maedica
JID - 101526930
PMC - PMC9720662
EDAT- 2022/12/22 06:00
MHDA- 2022/12/22 06:01
PMCR- 2022/09/01
CRDT- 2022/12/21 02:12
PHST- 2022/12/21 02:12 [entrez]
PHST- 2022/12/22 06:00 [pubmed]
PHST- 2022/12/22 06:01 [medline]
PHST- 2022/09/01 00:00 [pmc-release]
AID - 10.26574/maedica.2022.17.3.596 [doi]
PST - ppublish
SO  - Maedica (Bucur). 2022 Sep;17(3):596-601. doi: 10.26574/maedica.2022.17.3.596.