PMID- 36541364
OWN - NLM
STAT- MEDLINE
DCOM- 20230125
LR  - 20230202
IS  - 1753-0407 (Electronic)
IS  - 1753-0393 (Print)
IS  - 1753-0407 (Linking)
VI  - 15
IP  - 1
DP  - 2023 Jan
TI  - The influence of shorter red blood cell lifespan on the rate of HbA1c target 
      achieved in type 2 diabetes patients with a HbA1c detection value lower than 7.
PG  - 7-14
LID - 10.1111/1753-0407.13345 [doi]
AB  - BACKGROUND: Variations in the red blood cell (RBC) lifespan can affect 
      glycosylated hemoglobin (HbA1c) test values, but there is still a lack of 
      evidence regarding how and to what degree the RBC lifespan influences HbA1c in 
      the type 2 diabetes mellitus (T2DM) population owing to the restriction of 
      traditional RBC lifespan-detection means. This study aimed to investigate the 
      influence of RBC lifespan variation on HbA1c values in T2DM patients with a HbA1c 
      detection value lower than 7%. METHODS: Patients with HbA1c <7% were divided into 
      two groups: RBC lifespan <90 days and RBC lifespan >/=90 days. We collected blood 
      glucose levels at seven time points for three consecutive months, assessed the 
      HbA1c and glycosylated albumin levels, and calculated the hemoglobin glycation 
      index (HGI) for each patient. RESULTS: There were no statistical differences in 
      the HbA1c value between two groups, but the estimated glycosylated hemoglobin 
      (eHbA1c) was significantly higher in patients with an RBC lifespan <90 days. The 
      proportion of the eHbA1c >/=7% in the group with an RBC lifespan <90 days was 
      significantly higher than the other group (33.87% vs. 12.50%, p < .01). Pearson 
      analysis showed a significant negative correlation between RBC lifespan and the 
      HGI in patients with T2DM (r = -0.348, p < .01). CONCLUSION: A reduced RBC 
      lifespan in T2DM patients caused a noticeable underestimate of the blood glucose 
      levels as presented by HbA1c detection value.
CI  - (c) 2022 The Authors. Journal of Diabetes published by Ruijin Hospital, Shanghai 
      JiaoTong University School of Medicine and John Wiley & Sons Australia, Ltd.
FAU - Wang, Junmei
AU  - Wang J
AD  - NHC Key Laboratory of Hormones and Development, Chu Hsien-I Memorial Hospital and 
      Tianjin Institute of Endocrinology, Tianjin Medical University, Tianjin, China.
AD  - Tianjin Key Laboratory of Metabolic Diseases, Tianjin Medical University, 
      Tianjin, China.
FAU - Zhang, Li
AU  - Zhang L
AD  - NHC Key Laboratory of Hormones and Development, Chu Hsien-I Memorial Hospital and 
      Tianjin Institute of Endocrinology, Tianjin Medical University, Tianjin, China.
AD  - Tianjin Key Laboratory of Metabolic Diseases, Tianjin Medical University, 
      Tianjin, China.
FAU - Bai, Yu
AU  - Bai Y
AD  - NHC Key Laboratory of Hormones and Development, Chu Hsien-I Memorial Hospital and 
      Tianjin Institute of Endocrinology, Tianjin Medical University, Tianjin, China.
AD  - Tianjin Key Laboratory of Metabolic Diseases, Tianjin Medical University, 
      Tianjin, China.
FAU - Wang, Xinli
AU  - Wang X
AD  - NHC Key Laboratory of Hormones and Development, Chu Hsien-I Memorial Hospital and 
      Tianjin Institute of Endocrinology, Tianjin Medical University, Tianjin, China.
AD  - Tianjin Key Laboratory of Metabolic Diseases, Tianjin Medical University, 
      Tianjin, China.
FAU - Wang, Weilin
AU  - Wang W
AD  - NHC Key Laboratory of Hormones and Development, Chu Hsien-I Memorial Hospital and 
      Tianjin Institute of Endocrinology, Tianjin Medical University, Tianjin, China.
AD  - Tianjin Key Laboratory of Metabolic Diseases, Tianjin Medical University, 
      Tianjin, China.
FAU - Li, Jing
AU  - Li J
AD  - NHC Key Laboratory of Hormones and Development, Chu Hsien-I Memorial Hospital and 
      Tianjin Institute of Endocrinology, Tianjin Medical University, Tianjin, China.
AD  - Tianjin Key Laboratory of Metabolic Diseases, Tianjin Medical University, 
      Tianjin, China.
FAU - Zhou, Saijun
AU  - Zhou S
AUID- ORCID: 0000-0002-5761-7568
AD  - NHC Key Laboratory of Hormones and Development, Chu Hsien-I Memorial Hospital and 
      Tianjin Institute of Endocrinology, Tianjin Medical University, Tianjin, China.
AD  - Tianjin Key Laboratory of Metabolic Diseases, Tianjin Medical University, 
      Tianjin, China.
LA  - eng
GR  - 2017KJ212/Science and Technology Fund of Tianjin Education Commission/
GR  - TJYXZDXK-032A/Tianjin Key Medical Discipline(Specialty) Construction Project/
PT  - Journal Article
DEP - 20221221
PL  - Australia
TA  - J Diabetes
JT  - Journal of diabetes
JID - 101504326
RN  - 0 (Glycated Hemoglobin)
RN  - 0 (Blood Glucose)
SB  - IM
MH  - Humans
MH  - *Diabetes Mellitus, Type 2
MH  - Glycated Hemoglobin
MH  - Blood Glucose/metabolism
MH  - Longevity
MH  - Erythrocytes/chemistry/metabolism
PMC - PMC9870739
OTO - NOTNLM
OT  - 2型糖尿病
OT  - glycosylated hemoglobin
OT  - mean blood glucose
OT  - red blood cell lifespan
OT  - type 2 diabetes
OT  - 糖化血红蛋白
OT  - 红细胞寿命
OT  - 血糖均值
EDAT- 2022/12/22 06:00
MHDA- 2023/01/26 06:00
PMCR- 2022/12/21
CRDT- 2022/12/21 06:23
PHST- 2022/10/14 00:00 [revised]
PHST- 2022/06/30 00:00 [received]
PHST- 2022/12/01 00:00 [accepted]
PHST- 2022/12/22 06:00 [pubmed]
PHST- 2023/01/26 06:00 [medline]
PHST- 2022/12/21 06:23 [entrez]
PHST- 2022/12/21 00:00 [pmc-release]
AID - JDB13345 [pii]
AID - 10.1111/1753-0407.13345 [doi]
PST - ppublish
SO  - J Diabetes. 2023 Jan;15(1):7-14. doi: 10.1111/1753-0407.13345. Epub 2022 Dec 21.