PMID- 36541706
OWN - NLM
STAT- MEDLINE
DCOM- 20230112
LR  - 20230112
IS  - 1520-5118 (Electronic)
IS  - 0021-8561 (Linking)
VI  - 71
IP  - 1
DP  - 2023 Jan 11
TI  - Targeting mTOR Signaling by Dietary Polysaccharides in Cancer Prevention: 
      Advances and Challenges.
PG  - 96-109
LID - 10.1021/acs.jafc.2c06780 [doi]
AB  - Cancer is the most serious problem for public health. Traditional treatments 
      often come with unavoidable side effects. Therefore, the therapeutic effects of 
      natural products with wide sources and low toxicity are attracting more and more 
      attention. Polysaccharides have been shown to have cancer-fighting potential, but 
      the molecular mechanisms remain unclear. The mammalian target of rapamycin (mTOR) 
      pathway has become an attractive target of antitumor therapy research in recent 
      years. The regulation of mTOR pathway not only affects cell proliferation and 
      growth but also has an important effect in tumor metabolism. Recent studies 
      indicate that dietary polysaccharides play a vital role in cancer prevention and 
      treatment by regulating mTOR pathway. Here, the progress in targeting mTOR 
      signaling by dietary polysaccharides in cancer prevention and their molecular 
      mechanisms are systemically summarized. It will promote the understanding of the 
      anticancer effects of polysaccharides and provide reference to investigators of 
      this cutting edge field.
FAU - Li, Mengyuan
AU  - Li M
AD  - Hunan Key Laboratory of Grain-oil Deep Process and Quality Control, College of 
      Food Science and Engineering, Central South University of Forestry and 
      Technology, Changsha, Hunan 410004, China.
AD  - Hunan Key Laboratory of Forestry Edible Resources Safety and Processing, Central 
      South University of Forestry and Technology, Changsha, Hunan 410004, China.
FAU - Hu, Zuomin
AU  - Hu Z
AD  - Hunan Key Laboratory of Grain-oil Deep Process and Quality Control, College of 
      Food Science and Engineering, Central South University of Forestry and 
      Technology, Changsha, Hunan 410004, China.
FAU - Guo, Tianyi
AU  - Guo T
AD  - Hunan Key Laboratory of Grain-oil Deep Process and Quality Control, College of 
      Food Science and Engineering, Central South University of Forestry and 
      Technology, Changsha, Hunan 410004, China.
FAU - Xie, Tiantian
AU  - Xie T
AD  - Hunan Key Laboratory of Grain-oil Deep Process and Quality Control, College of 
      Food Science and Engineering, Central South University of Forestry and 
      Technology, Changsha, Hunan 410004, China.
FAU - Tang, Yanqin
AU  - Tang Y
AD  - Hunan Key Laboratory of Grain-oil Deep Process and Quality Control, College of 
      Food Science and Engineering, Central South University of Forestry and 
      Technology, Changsha, Hunan 410004, China.
FAU - Wu, Xiuxiu
AU  - Wu X
AD  - Hunan Key Laboratory of Grain-oil Deep Process and Quality Control, College of 
      Food Science and Engineering, Central South University of Forestry and 
      Technology, Changsha, Hunan 410004, China.
FAU - Luo, Feijun
AU  - Luo F
AUID- ORCID: 0000-0001-7489-544X
AD  - Hunan Key Laboratory of Grain-oil Deep Process and Quality Control, College of 
      Food Science and Engineering, Central South University of Forestry and 
      Technology, Changsha, Hunan 410004, China.
AD  - Hunan Key Laboratory of Forestry Edible Resources Safety and Processing, Central 
      South University of Forestry and Technology, Changsha, Hunan 410004, China.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20221221
PL  - United States
TA  - J Agric Food Chem
JT  - Journal of agricultural and food chemistry
JID - 0374755
RN  - 0 (Polysaccharides)
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
RN  - W36ZG6FT64 (Sirolimus)
RN  - EC 2.7.1.1 (MTOR protein, human)
SB  - IM
MH  - Humans
MH  - *Polysaccharides/pharmacology/therapeutic use
MH  - TOR Serine-Threonine Kinases/genetics/metabolism
MH  - Signal Transduction
MH  - *Neoplasms/metabolism
MH  - Sirolimus/pharmacology/therapeutic use
OTO - NOTNLM
OT  - cancer
OT  - dietary polysaccharides
OT  - mTOR
OT  - signaling pathway
EDAT- 2022/12/22 06:00
MHDA- 2023/01/13 06:00
CRDT- 2022/12/21 08:52
PHST- 2022/12/22 06:00 [pubmed]
PHST- 2023/01/13 06:00 [medline]
PHST- 2022/12/21 08:52 [entrez]
AID - 10.1021/acs.jafc.2c06780 [doi]
PST - ppublish
SO  - J Agric Food Chem. 2023 Jan 11;71(1):96-109. doi: 10.1021/acs.jafc.2c06780. Epub 
      2022 Dec 21.