PMID- 36542200
OWN - NLM
STAT- MEDLINE
DCOM- 20240124
LR  - 20240201
IS  - 1435-165X (Electronic)
IS  - 1018-8827 (Linking)
VI  - 33
IP  - 1
DP  - 2024 Jan
TI  - Cortical thickness abnormalities in autism spectrum disorder.
PG  - 65-77
LID - 10.1007/s00787-022-02133-0 [doi]
AB  - The pathological mechanism of autism spectrum disorder (ASD) remains unclear. 
      Nowadays, surface-based morphometry (SBM) based on structural magnetic resonance 
      imaging (sMRI) techniques have reported cortical thickness (CT) variations in 
      ASD. However, the findings were inconsistent and heterogeneous. This current 
      meta-analysis conducted a whole-brain vertex-wise coordinate-based meta-analysis 
      (CBMA) on CT studies to explore the most noticeable and robust CT changes in ASD 
      individuals by applying the seed-based d mapping (SDM) program. A total of 26 
      investigations comprised 27 datasets were included, containing 1,635 subjects 
      with ASD and 1470 HC, along with 94 coordinates. Individuals with ASD exhibited 
      significantly altered CT in several regions compared to HC, including four 
      clusters with thicker CT in the right superior temporal gyrus (STG.R), the left 
      middle temporal gyrus (MTG.L), the left anterior cingulate/paracingulate gyri, 
      the right superior frontal gyrus (SFG.R, medial orbital parts), as well as three 
      clusters with cortical thinning including the left parahippocampal gyrus (PHG.L), 
      the right precentral gyrus (PCG.R) and the left middle frontal gyrus (MFG.L). 
      Adults with ASD only demonstrated CT thinning in the right parahippocampal gyrus 
      (PHG.R), revealed by subgroup meta-analyses. Meta-regression analyses found that 
      CT in STG.R was positively correlated with age. Meanwhile, CT in MFG.L and PHG.L 
      had negative correlations with the age of ASD individuals. These results 
      suggested a complicated and atypical cortical development trajectory in ASD, and 
      would provide a deeper understanding of the neural mechanism underlying the 
      cortical morphology in ASD.
CI  - (c) 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany.
FAU - Shen, Liancheng
AU  - Shen L
AD  - Department of Psychiatry, Shandong Daizhuang Hospital, Jining, China.
FAU - Zhang, Junqing
AU  - Zhang J
AD  - Department of Pharmacy, Shandong Daizhuang Hospital, Jining, China.
FAU - Fan, Shiran
AU  - Fan S
AD  - School of Mental Health, Jining Medical University, Jining, China.
FAU - Ping, Liangliang
AU  - Ping L
AD  - Department of Psychiatry, Xiamen Xianyue Hospital, Xiamen, China.
FAU - Yu, Hao
AU  - Yu H
AD  - School of Mental Health, Jining Medical University, Jining, China.
FAU - Xu, Fangfang
AU  - Xu F
AD  - School of Mental Health, Jining Medical University, Jining, China.
FAU - Cheng, Yuqi
AU  - Cheng Y
AD  - Department of Psychiatry, The First Affiliated Hospital of Kunming Medical 
      University, Kunming, China.
FAU - Xu, Xiufeng
AU  - Xu X
AD  - Department of Psychiatry, The First Affiliated Hospital of Kunming Medical 
      University, Kunming, China.
FAU - Yang, Chunyan
AU  - Yang C
AD  - School of Rehabilitation Medicine, Jining Medical University, Jining, China. 
      ychunyan2022@126.com.
FAU - Zhou, Cong
AU  - Zhou C
AD  - School of Mental Health, Jining Medical University, Jining, China. 
      doctorzhoucong@163.com.
AD  - Department of Psychology, Affiliated Hospital of Jining Medical University, 
      Jining, China. doctorzhoucong@163.com.
LA  - eng
GR  - 81901358/National Natural Science Foundation of China/
GR  - ZR2019BH001/Natural Science Foundation of Shandong Province/
GR  - tsqn201909146/Young Taishan Scholars of Shandong Province/
GR  - 202003061210/Medical and Health Science and Technology Development Plan of 
      Shandong Province/
GR  - 2021YXNS024/Key Research and Development Plan of Jining City/
GR  - JYGC2021KJ006/Cultivation Plan of High-level Scientific Research Projects of 
      Jining Medical University/
GR  - SDYJG19212/Postgraduate Education and Teaching Reform Research Project of 
      Shandong Province/
GR  - 600903001/Supporting Fund for Teachers' Research of Jining Medical University/
PT  - Journal Article
PT  - Meta-Analysis
DEP - 20221221
PL  - Germany
TA  - Eur Child Adolesc Psychiatry
JT  - European child & adolescent psychiatry
JID - 9212296
SB  - IM
MH  - Adult
MH  - Humans
MH  - *Autism Spectrum Disorder/diagnostic imaging/pathology
MH  - Brain/pathology
MH  - Magnetic Resonance Imaging/methods
MH  - Brain Mapping/methods
OTO - NOTNLM
OT  - Autism spectrum disorder
OT  - Cortical thickness
OT  - Seed-based d mapping
OT  - Structural magnetic resonance imaging
OT  - Surface-based morphometry
EDAT- 2022/12/22 06:00
MHDA- 2024/01/24 06:42
CRDT- 2022/12/21 11:17
PHST- 2022/09/22 00:00 [received]
PHST- 2022/12/15 00:00 [accepted]
PHST- 2024/01/24 06:42 [medline]
PHST- 2022/12/22 06:00 [pubmed]
PHST- 2022/12/21 11:17 [entrez]
AID - 10.1007/s00787-022-02133-0 [pii]
AID - 10.1007/s00787-022-02133-0 [doi]
PST - ppublish
SO  - Eur Child Adolesc Psychiatry. 2024 Jan;33(1):65-77. doi: 
      10.1007/s00787-022-02133-0. Epub 2022 Dec 21.