PMID- 36543746
OWN - NLM
STAT- MEDLINE
DCOM- 20230110
LR  - 20230111
IS  - 1744-313X (Electronic)
IS  - 1744-3121 (Linking)
VI  - 50
IP  - 1
DP  - 2023 Feb
TI  - Association of class II HLA alleles with susceptibility to develop 
      immune-mediated diseases in Paraguayan patients.
PG  - 12-18
LID - 10.1111/iji.12609 [doi]
AB  - Genetic and nongenetic factors are involved in the pathogenesis of 
      immune-mediated inflammatory diseases (IMIDs). The best-known genetic factor for 
      susceptibility to IMIDs is the human leukocyte antigen (HLA). The aim of the 
      present study was to evaluate the association of HLA class II genes with the risk 
      of systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), and systemic 
      sclerosis (SSc) in the Paraguayan population. We included 254 patients with IMIDs 
      (101 SLE, 103 RA, and 50 SSc) and 50 healthy controls. The haplotypes of five 
      genes corresponding to HLA class II genes and their relationship to the IMIDs 
      studied were determined. Note that 84.6% were women, with a mean age of 43.4 +/- 14 
      years. Among the associated HLA alleles, we found the previously identified risk 
      factors in other populations like HLA-DRB1*03:01 and HLA-DRB1*14:02 for RA, as 
      well as new ones not previously identified, such as DPA1*02:01 for SLE and, 
      DB1*02:01 for RA and SSc. In the genetic association analysis, already known 
      associations have been replicated, and unpublished associations have been 
      identified in Paraguayan patients with IMIDs. This is the first genetic 
      association study in Paraguayan patients with IMIDs.
CI  - (c) 2022 John Wiley & Sons Ltd.
FAU - Acosta-Colman, Isabel
AU  - Acosta-Colman I
AUID- ORCID: 0000-0001-7296-5950
AD  - Departamento de Reumatologia, Facultad de Ciencias Medicas, Universidad Nacional 
      de Asuncion, San Lorenzo, Paraguay.
FAU - Cabrera-Villalba, Sonia
AU  - Cabrera-Villalba S
AUID- ORCID: 0000-0001-6224-2679
AD  - Departamento de Reumatologia, Facultad de Ciencias Medicas, Universidad Nacional 
      de Asuncion, San Lorenzo, Paraguay.
FAU - Ayala-Lugo, Ana
AU  - Ayala-Lugo A
AUID- ORCID: 0000-0002-5844-1445
AD  - Instituto de Investigacion en Ciencias de la Salud, Laboratorio de Genetica 
      Molecular, Universidad Nacional de Asuncion, San Lorenzo, Paraguay.
FAU - Jolly, Valerie
AU  - Jolly V
AUID- ORCID: 0000-0001-8249-5374
AD  - Instituto de Investigacion en Ciencias de la Salud, Laboratorio de Genetica 
      Molecular, Universidad Nacional de Asuncion, San Lorenzo, Paraguay.
FAU - Vazquez, Marcos
AU  - Vazquez M
AUID- ORCID: 0000-0003-2623-0050
AD  - Departamento de Reumatologia, Facultad de Ciencias Medicas, Universidad Nacional 
      de Asuncion, San Lorenzo, Paraguay.
FAU - Morel, Zoilo
AU  - Morel Z
AUID- ORCID: 0000-0001-6438-446X
AD  - Departamento de Reumatologia, Facultad de Ciencias Medicas, Universidad Nacional 
      de Asuncion, San Lorenzo, Paraguay.
FAU - Langjahr, Patricia
AU  - Langjahr P
AUID- ORCID: 0000-0001-9793-3373
AD  - Facultad de Ciencias Quimicas, Universidad Nacional de Asuncion, San Lorenzo, 
      Paraguay.
FAU - Duarte, Margarita
AU  - Duarte M
AUID- ORCID: 0000-0002-7130-3717
AD  - Departamento de Reumatologia, Facultad de Ciencias Medicas, Universidad Nacional 
      de Asuncion, San Lorenzo, Paraguay.
FAU - Zarate, Ruth
AU  - Zarate R
AUID- ORCID: 0000-0002-8024-021X
AD  - Laboratorio Curie, Asuncion, Paraguay.
FAU - Acosta, Maria Eugenia
AU  - Acosta ME
AUID- ORCID: 0000-0003-0801-4397
AD  - Instituto de Investigacion en Ciencias de la Salud, Laboratorio de Genetica 
      Molecular, Universidad Nacional de Asuncion, San Lorenzo, Paraguay.
FAU - Avila-Pedretti, Gabriela
AU  - Avila-Pedretti G
AUID- ORCID: 0000-0002-6526-6278
AD  - Departamento de Reumatologia, Facultad de Ciencias Medicas, Universidad Nacional 
      de Asuncion, San Lorenzo, Paraguay.
FAU - Julia, Antonio
AU  - Julia A
AUID- ORCID: 0000-0001-6064-3620
AD  - Group de Recerca en Reumatologia, Institut de Recerca Vall d'Hebron, Barcelona, 
      Spain.
FAU - Martinez, Maria Teresa
AU  - Martinez MT
AUID- ORCID: 0000-0002-0024-4596
AD  - Laboratorio Curie, Asuncion, Paraguay.
FAU - Marsal, Sara
AU  - Marsal S
AUID- ORCID: 0000-0001-5515-3854
AD  - Group de Recerca en Reumatologia, Institut de Recerca Vall d'Hebron, Barcelona, 
      Spain.
LA  - eng
GR  - 14-INV-039/This project was co-financed by the Consejo Nacional de Ciencia y 
      Tecnologia (CONACYT) with the support of the FEEI/
PT  - Journal Article
DEP - 20221221
PL  - England
TA  - Int J Immunogenet
JT  - International journal of immunogenetics
JID - 101232337
RN  - 0 (Immunomodulating Agents)
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - Humans
MH  - Female
MH  - Adult
MH  - Middle Aged
MH  - Male
MH  - Genetic Predisposition to Disease
MH  - Alleles
MH  - Immunomodulating Agents
MH  - *Lupus Erythematosus, Systemic/genetics
MH  - HLA-DRB1 Chains/genetics
MH  - *Arthritis, Rheumatoid/genetics
MH  - Haplotypes
OTO - NOTNLM
OT  - human leukocyte antigen (HLA)
OT  - major histocompatibility complex (MHC)
OT  - paraguayans
OT  - rheumatoid arthritis
OT  - systemic lupus erythematosus
OT  - systemic sclerosis
EDAT- 2022/12/22 06:00
MHDA- 2023/01/11 06:00
CRDT- 2022/12/21 22:22
PHST- 2022/11/06 00:00 [revised]
PHST- 2022/07/29 00:00 [received]
PHST- 2022/11/14 00:00 [accepted]
PHST- 2022/12/22 06:00 [pubmed]
PHST- 2023/01/11 06:00 [medline]
PHST- 2022/12/21 22:22 [entrez]
AID - 10.1111/iji.12609 [doi]
PST - ppublish
SO  - Int J Immunogenet. 2023 Feb;50(1):12-18. doi: 10.1111/iji.12609. Epub 2022 Dec 
      21.