PMID- 36545022
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20221223
IS  - 2297-055X (Print)
IS  - 2297-055X (Electronic)
IS  - 2297-055X (Linking)
VI  - 9
DP  - 2022
TI  - Metastatic patterns and prognosis of patients with primary malignant cardiac 
      tumor.
PG  - 1009765
LID - 10.3389/fcvm.2022.1009765 [doi]
LID - 1009765
AB  - BACKGROUND: Distant metastases are independent negative prognostic factors for 
      patients with primary malignant cardiac tumors (PMCT). This study aims to further 
      investigate metastatic patterns and their prognostic effects in patients with 
      PMCT. MATERIALS AND METHODS: This multicenter retrospective study included 218 
      patients with PMCT diagnosed between 2010 and 2017 from Surveillance, 
      Epidemiology, and End Results (SEER) database. Logistic regression was utilized 
      to identify metastatic risk factors. A Chi-square test was performed to assess 
      the metastatic rate. Kaplan-Meier methods and Cox regression analysis were used 
      to analyze the prognostic effects of metastatic patterns. RESULTS: Sarcoma (p = 
      0.002) and tumor size inverted question mark4 cm (p = 0.006) were independent risk factors of distant 
      metastases in patients with PMCT. Single lung metastasis (about 34%) was the most 
      common of all metastatic patterns, and lung metastases occurred more frequently 
      (17.9%) than bone, liver, and brain. Brain metastases had worst overall survival 
      (OS) and cancer-specific survival (CSS) among other metastases, like lung, bone, 
      liver, and brain (OS: HR = 3.20, 95% CI: 1.02-10.00, p = 0.046; CSS: HR = 3.53, 
      95% CI: 1.09-11.47, p = 0.036). CONCLUSION: Patients with PMCT who had sarcoma or 
      a tumor larger than 4 cm had a higher risk of distant metastases. Lung was the 
      most common metastatic site, and brain metastases had worst survival among 
      others, such as lung, bone, liver, and brain. The results of this study provide 
      insight for early detection, diagnosis, and treatment of distant metastases 
      associated with PMCT.
CI  - Copyright (c) 2022 Guan, Wei, Tang, Zhao, Lu, Feng, Teng, Luo, Chi, Ou and Chen.
FAU - Guan, Tianwang
AU  - Guan T
AD  - Department of Cardiology, Laboratory of Heart Center, Zhujiang Hospital, Southern 
      Medical University, Guangzhou, China.
AD  - Guangdong Provincial Biomedical Engineering Technology Research Center for 
      Cardiovascular Disease, Sino-Japanese Cooperation Platform for Translational 
      Research in Heart Failure, Guangzhou, China.
FAU - Wei, Qingqian
AU  - Wei Q
AD  - Department of Clinical Medicine, Clinical Medical School, Guangzhou Medical 
      University, Guangzhou, China.
FAU - Tang, Yongshi
AU  - Tang Y
AD  - Department of Clinical Medicine, Clinical Medical School, Guangzhou Medical 
      University, Guangzhou, China.
FAU - Zhao, Hongjun
AU  - Zhao H
AD  - Department of Clinical Medicine, Clinical Medical School, Guangzhou Medical 
      University, Guangzhou, China.
FAU - Lu, Zhenxing
AU  - Lu Z
AD  - Department of Cardiology, Laboratory of Heart Center, Zhujiang Hospital, Southern 
      Medical University, Guangzhou, China.
AD  - Guangdong Provincial Biomedical Engineering Technology Research Center for 
      Cardiovascular Disease, Sino-Japanese Cooperation Platform for Translational 
      Research in Heart Failure, Guangzhou, China.
FAU - Feng, Weijing
AU  - Feng W
AD  - State Key Laboratory of Organ Failure Research, Guangdong Provincial Key Lab of 
      Shock and Microcirculation, Department of Cardiology, Nanfang Hospital, Southern 
      Medical University, Guangzhou, China.
FAU - Teng, Yintong
AU  - Teng Y
AD  - Department of Cardiology, Laboratory of Heart Center, Zhujiang Hospital, Southern 
      Medical University, Guangzhou, China.
AD  - Guangdong Provincial Biomedical Engineering Technology Research Center for 
      Cardiovascular Disease, Sino-Japanese Cooperation Platform for Translational 
      Research in Heart Failure, Guangzhou, China.
FAU - Luo, Zehao
AU  - Luo Z
AD  - Department of Clinical Medicine, Clinical Medical School, Guangzhou Medical 
      University, Guangzhou, China.
FAU - Chi, Kaiyi
AU  - Chi K
AD  - Department of Clinical Medicine, Clinical Medical School, Guangzhou Medical 
      University, Guangzhou, China.
FAU - Ou, Caiwen
AU  - Ou C
AD  - Department of Cardiology, Laboratory of Heart Center, Zhujiang Hospital, Southern 
      Medical University, Guangzhou, China.
AD  - Dongguan Hospital of Southern Medical University, Southern Medical University, 
      Dongguan, China.
FAU - Chen, Minsheng
AU  - Chen M
AD  - Department of Cardiology, Laboratory of Heart Center, Zhujiang Hospital, Southern 
      Medical University, Guangzhou, China.
AD  - Guangdong Provincial Biomedical Engineering Technology Research Center for 
      Cardiovascular Disease, Sino-Japanese Cooperation Platform for Translational 
      Research in Heart Failure, Guangzhou, China.
LA  - eng
PT  - Journal Article
DEP - 20221205
PL  - Switzerland
TA  - Front Cardiovasc Med
JT  - Frontiers in cardiovascular medicine
JID - 101653388
PMC - PMC9760733
OTO - NOTNLM
OT  - Epidemiology
OT  - Surveillance
OT  - and End Results (SEER) database
OT  - cardio-oncology
OT  - distant metastasis
OT  - primary malignant cardiac tumor
OT  - prognosis
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/12/23 06:00
MHDA- 2022/12/23 06:01
PMCR- 2022/01/01
CRDT- 2022/12/22 02:27
PHST- 2022/08/02 00:00 [received]
PHST- 2022/11/16 00:00 [accepted]
PHST- 2022/12/22 02:27 [entrez]
PHST- 2022/12/23 06:00 [pubmed]
PHST- 2022/12/23 06:01 [medline]
PHST- 2022/01/01 00:00 [pmc-release]
AID - 10.3389/fcvm.2022.1009765 [doi]
PST - epublish
SO  - Front Cardiovasc Med. 2022 Dec 5;9:1009765. doi: 10.3389/fcvm.2022.1009765. 
      eCollection 2022.