PMID- 36545295
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20221223
IS  - 1178-7007 (Print)
IS  - 1178-7007 (Electronic)
IS  - 1178-7007 (Linking)
VI  - 15
DP  - 2022
TI  - Relationship Between Subclinical Cardiovascular Diseases and Cardiac 
      Morpho-Functional Parameters in Preclinical Stage A/B Heart Failure Adults with 
      Type 2 Diabetes.
PG  - 3923-3931
LID - 10.2147/DMSO.S385088 [doi]
AB  - PURPOSE: Type 2 diabetes mellitus (T2DM) is a common risk factor for 
      cardiovascular disease which increases the risk of heart failure. This study 
      aimed to determine whether clinical characteristics and subclinical 
      cardiovascular disease (CVD) features are correlated with echocardiographic 
      morpho-functional parameters of T2DM patients. PATIENTS AND METHODS: Two hundred 
      and fifty-five T2DM patients without a history of coronary heart disease were 
      enrolled in this cross-sectional study. The demographic characteristics, glucose 
      and lipid levels were assessed for each patient. Carotid ultrasonography and 
      peripheral artery examination were performed to measure carotid intima-media 
      thickness (cIMT), carotid plaque, ankle-brachial index (ABI), brachial artery 
      pulse wave velocity (baPWV), and carotid-femoral pulse wave velocity (cfPWV). 
      Furthermore, echocardiography was conducted to evaluate cardiac morphology and 
      systolic and diastolic function. The relationship between clinical 
      characteristics, subclinical cardiovascular diseases, and cardiac 
      morpho-functional parameters was explored with the Pearson and stepwise 
      multivariable linear regression analyses. RESULTS: A total of 255 subjects aged 
      18-80 years were enrolled in the study. Multiple regression analysis revealed 
      that left ventricular mass index (LVMI) was correlated with age (beta=0.463, p = 
      0.000) and systolic blood pressure (SBP) (beta=0.179, p = 0.003). Relative wall 
      thickness (RWT) was related to cfPWV (beta=0.006, p = 0.007) and homeostasis model 
      assessment of insulin resistance (HOMA-IR) (beta=0.000, p = 0.036). In contrast, 
      left ventricular ejection fraction (LVEF) was inversely related to cIMT 
      (beta=-0.925, p = 0.019). The ratio of the peak flow velocity of early diastole to 
      atrial contraction (peak E/A) was correlated with age (beta=-0.014, p = 0.000), 
      diastolic blood pressure (DBP) (beta=-0.006, p = 0.001) and cfPWV (beta=-0.025, p = 
      0.044). CONCLUSION: In preclinical stage A/B heart failure adults with T2DM, age, 
      BP, HOMA-IR, cfPWV and cIMT are correlated with cardiac morpho-functional 
      parameters.
CI  - (c) 2022 Xiao et al.
FAU - Xiao, Yan
AU  - Xiao Y
AUID- ORCID: 0000-0002-1554-1921
AD  - Department of Endocrinology, Beijing Chaoyang Hospital, Capital Medical 
      University, Beijing, People's Republic of China.
FAU - Yao, Xin-Yue
AU  - Yao XY
AD  - Department of Endocrinology, Beijing Chaoyang Hospital, Capital Medical 
      University, Beijing, People's Republic of China.
FAU - Wang, Yong-Hui
AU  - Wang YH
AD  - Department of Endocrinology, Beijing Chaoyang Hospital, Capital Medical 
      University, Beijing, People's Republic of China.
FAU - Han, Lan-Wen
AU  - Han LW
AD  - Department of Endocrinology, Beijing Chaoyang Hospital, Capital Medical 
      University, Beijing, People's Republic of China.
FAU - Li, Lian-Xia
AU  - Li LX
AD  - Department of Endocrinology, Beijing Chaoyang Hospital, Capital Medical 
      University, Beijing, People's Republic of China.
FAU - Li, Ming
AU  - Li M
AD  - Department of Endocrinology, National Health Commission (NHC) Key Laboratory of 
      Endocrinology, Peking Union Medical College Hospital, Peking Union Medical 
      College and Chinese Academy of Medical Sciences, Beijing, People's Republic of 
      China.
FAU - Gao, Shan
AU  - Gao S
AD  - Department of Endocrinology, Beijing Xuanwu Hospital, Capital Medical University, 
      Beijing, People's Republic of China.
LA  - eng
PT  - Journal Article
DEP - 20221215
PL  - New Zealand
TA  - Diabetes Metab Syndr Obes
JT  - Diabetes, metabolic syndrome and obesity : targets and therapy
JID - 101515585
PMC - PMC9762254
OTO - NOTNLM
OT  - echocardiography
OT  - preclinical stage A/B heart failure
OT  - subclinical cardiovascular diseases
OT  - type 2 diabetes mellitus
COIS- The authors declare that there is no conflict of interests.
EDAT- 2022/12/23 06:00
MHDA- 2022/12/23 06:01
PMCR- 2022/12/15
CRDT- 2022/12/22 02:34
PHST- 2022/08/19 00:00 [received]
PHST- 2022/11/25 00:00 [accepted]
PHST- 2022/12/22 02:34 [entrez]
PHST- 2022/12/23 06:00 [pubmed]
PHST- 2022/12/23 06:01 [medline]
PHST- 2022/12/15 00:00 [pmc-release]
AID - 385088 [pii]
AID - 10.2147/DMSO.S385088 [doi]
PST - epublish
SO  - Diabetes Metab Syndr Obes. 2022 Dec 15;15:3923-3931. doi: 10.2147/DMSO.S385088. 
      eCollection 2022.