PMID- 36545386
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20221223
IS  - 1756-283X (Print)
IS  - 1756-2848 (Electronic)
IS  - 1756-283X (Linking)
VI  - 15
DP  - 2022
TI  - Medication adherence in women with IBD of childbearing age likely associated with 
      disease knowledge.
PG  - 17562848221144088
LID - 10.1177/17562848221144088 [doi]
LID - 17562848221144088
AB  - BACKGROUND: Medication adherence in inflammatory bowel disease (IBD) is crucial, 
      particularly during pregnancy. Unplanned pregnancies are common; therefore, 
      efforts to maximise adherence should not be restricted to pregnant women. 
      OBJECTIVES: We aimed to assess medication adherence in women with IBD of 
      childbearing age, regardless of their reproduction plans. DESIGN: We performed a 
      multi-centre pilot questionnaire study of women with IBD age 18-45 years. 
      METHODS: Survey questions included patient demographics, disease history, and 
      validated assessments of IBD and pregnancy knowledge, medication adherence and 
      quality of life. The primary outcome was rates and predictors of medication 
      adherence. RESULTS: In all, 72 women [58.3% Crohn's disease (CD) and 37.5% 
      ulcerative colitis] completed the survey. The median patient age was 30 years 
      [interquartile range (IQR): 24.8-36.0) and 37.5% had children. Medication 
      adherence was high (84%; median Medication Adherence Report Scale: 19.0/20; IQR: 
      17.0-20.0). Knowledge scores were adequate for both the Crohn's and Colitis 
      Knowledge (CCKnow; median: 15.5/30; IQR: 12.3-18.0) and Crohn's and Colitis 
      Pregnancy Knowledge (CCPKnow; median: 8.0/17; IQR: 4.0-11.0). Disease knowledge 
      was predictive of high medication adherence (CCPKnow: p = 0.02; CCKnow: 
      p ⩽ 0.01). Higher adherence was significantly associated with a diagnosis of CD 
      (p = 0.01), exposure to biological agents (p = 0.03) and immunomodulators 
      (p = 0.04), childbearing after diagnosis with IBD (p = 0.03), and correctly 
      understanding the importance of delivery modality (p = 0.02) and IBD activity in 
      pregnancy (p = 0.01). CONCLUSIONS: Following dedicated education at the IBD 
      clinic, medication adherence, disease-specific and pregnancy-specific knowledge 
      in women with IBD of childbearing age tends to be high. Unplanned pregnancies are 
      frequent; therefore, we should aim to maximise medication adherence in all women 
      of childbearing age to optimise maternofoetal outcomes if unexpected pregnancies 
      occur.
CI  - (c) The Author(s), 2022.
FAU - Laube, Robyn
AU  - Laube R
AUID- ORCID: 0000-0001-7997-5983
AD  - Faculty of Medicine and Health Sciences, Macquarie University, Sydney, NSW, 
      Australia.
AD  - Department of Gastroenterology, Macquarie University Hospital, Sydney, NSW, 
      Australia.
FAU - Selinger, Christian
AU  - Selinger C
AD  - Leeds Teaching Hospital NHS Trust, Leeds, UK.
FAU - Leong, Rupert W
AU  - Leong RW
AUID- ORCID: 0000-0001-5944-3488
AD  - Department of Gastroenterology and Hepatology, Concord Repatriation General 
      Hospital, Level 1 West, Hospital Road, Concord, NSW 2137, Australia.
AD  - Faculty of Medicine and Health Sciences, Macquarie University, Sydney, NSW, 
      Australia.
AD  - Department of Gastroenterology, Macquarie University Hospital, Sydney, NSW, 
      Australia.
LA  - eng
PT  - Journal Article
DEP - 20221215
PL  - England
TA  - Therap Adv Gastroenterol
JT  - Therapeutic advances in gastroenterology
JID - 101478893
PMC - PMC9761214
OTO - NOTNLM
OT  - inflammatory bowel disease
OT  - knowledge
OT  - medication adherence
OT  - pregnancy
OT  - women's healthcare
COIS- The authors declare that there is no conflict of interest.
EDAT- 2022/12/23 06:00
MHDA- 2022/12/23 06:01
PMCR- 2022/12/15
CRDT- 2022/12/22 02:38
PHST- 2022/08/10 00:00 [received]
PHST- 2022/11/21 00:00 [accepted]
PHST- 2022/12/22 02:38 [entrez]
PHST- 2022/12/23 06:00 [pubmed]
PHST- 2022/12/23 06:01 [medline]
PHST- 2022/12/15 00:00 [pmc-release]
AID - 10.1177_17562848221144088 [pii]
AID - 10.1177/17562848221144088 [doi]
PST - epublish
SO  - Therap Adv Gastroenterol. 2022 Dec 15;15:17562848221144088. doi: 
      10.1177/17562848221144088. eCollection 2022.