PMID- 36545880
OWN - NLM
STAT- MEDLINE
DCOM- 20230310
LR  - 20230405
IS  - 1802-9973 (Electronic)
IS  - 0862-8408 (Print)
IS  - 0862-8408 (Linking)
VI  - 72
IP  - 1
DP  - 2023 Mar 8
TI  - Nitric oxide and salt resistance in Dahl rats: no role of inducible NO synthase.
PG  - 123-127
AB  - Inducible NO synthase (NOS II) was proposed to play an important role in salt 
      resistance of Dahl salt-resistant (SR/Jr) rats. Its chronic inhibition by 
      specific inhibitors was accompanied by blood pressure (BP) elevation in animals 
      subjected to high salt intake. The aim of our study was to evaluate 1) whether 
      such inhibitors affect BP and/or its particular components (sympathetic tone and 
      NO-dependent vasodilation) only under the conditions of high salt intake, and 2) 
      whether similar BP effects are elicited after systemic or intracerebroventricular 
      (icv) application of these inhibitors. Wistar rats fed Altromin diet (0.45 % 
      NaCl) and SR/Jr rats fed either a low-salt (LS, 0.3 % NaCl) or a high-salt (HS, 4 
      % NaCl) diet were studied. Aminoguanidine (AMG) and 
      2-amino-5,6-dihydro-6-methyl-4H-1,3-thiazine (AMT) were used as NOS II 
      inhibitors. BP and its responses to acute blockade of renin-angiotensin system 
      (captopril), sympathetic nervous system (pentolinium) and NO synthase (L-NAME) 
      were measured in conscious cannulated rats. There were no significant changes of 
      BP or its components in either Wistar rats or SR/Jr rats subjected to chronic 
      inhibition of NOS II by peroral aminoguanidine administration (50 mg/kg/day for 4 
      weeks). This was true for SR/Jr rats fed either LS or HS diets. Furthermore, we 
      have studied BP effects of chronic icv administration of both NOS II inhibitors 
      in SR/Jr rats fed HS diet, but we failed to find any BP changes elicited by such 
      treatment. In conclusion, inducible NO synthase does not participate in the 
      resistance of SR/Jr rats to hypertensive effects of excess salt intake.
FAU - Zicha, J
AU  - Zicha J
AD  - Laboratory of Experimental Hypertension, Institute of Physiology of the Czech 
      Academy of Sciences, Prague 4, Czech Republic. Josef.Zicha@fgu.cas.cz.
FAU - Rezacova, L
AU  - Rezacova L
FAU - Vaneckova, I
AU  - Vaneckova I
LA  - eng
PT  - Journal Article
DEP - 20221222
PL  - Czech Republic
TA  - Physiol Res
JT  - Physiological research
JID - 9112413
RN  - 0 (Sodium Chloride, Dietary)
RN  - 451W47IQ8X (Sodium Chloride)
RN  - SCQ4EZQ113 (pimagedine)
RN  - 31C4KY9ESH (Nitric Oxide)
RN  - EC 1.14.13.39 (Nitric Oxide Synthase Type II)
RN  - EC 1.14.13.39 (Nitric Oxide Synthase)
SB  - IM
MH  - Rats
MH  - Animals
MH  - *Sodium Chloride, Dietary
MH  - Sodium Chloride
MH  - Rats, Inbred Dahl
MH  - Nitric Oxide
MH  - Nitric Oxide Synthase Type II
MH  - Rats, Wistar
MH  - Blood Pressure/physiology
MH  - *Hypertension/chemically induced
MH  - Nitric Oxide Synthase
PMC - PMC10069813
COIS- Conflict of Interest There is no conflict of interest.
EDAT- 2022/12/23 06:00
MHDA- 2023/03/11 06:00
PMCR- 2022/12/22
CRDT- 2022/12/22 03:55
PHST- 2022/12/23 06:00 [pubmed]
PHST- 2023/03/11 06:00 [medline]
PHST- 2022/12/22 03:55 [entrez]
PHST- 2022/12/22 00:00 [pmc-release]
AID - 935047 [pii]
AID - pr72_123 [pii]
AID - 10.33549/physiolres.935047 [doi]
PST - ppublish
SO  - Physiol Res. 2023 Mar 8;72(1):123-127. doi: 10.33549/physiolres.935047. Epub 2022 
      Dec 22.