PMID- 36546419
OWN - NLM
STAT- MEDLINE
DCOM- 20221223
LR  - 20230124
IS  - 2038-8306 (Electronic)
IS  - 1121-760X (Print)
IS  - 1121-760X (Linking)
VI  - 67
IP  - 1
DP  - 2023 Jan 2
TI  - Differential antigen expression between human apocrine sweat glands and eccrine 
      sweat glands.
LID - 10.4081/ejh.2023.3559 [doi]
LID - 3559
AB  - Bromhidrosis has a great negative impact on personal occupation and social 
      psychology. It is not yet clear whether bromhidrosis is caused by apocrine sweat 
      glands or the co-action of apocrine sweat glands and eccrine sweat glands. To 
      distinguish between apocrine sweat glands and eccrine sweat glands, specific 
      antigen markers for apocrine sweat glands and eccrine sweat glands must be found 
      first. In the study, we detected the expression of K7, K18, K19, Na+-K+-2Cl- 
      cotransporter 1 (NKCC1), carbonic anhydrase II (CAII), Forkhead transcription 
      factor a1 (Foxa1), homeobox transcription factor engrailed homeobox1 (En1), gross 
      cystic disease fluid protein-15 (GCDFP-15), mucin-1 (MUC-1), cluster of 
      differentiation 15 (CD15) and apolipoprotein (APOD) in eccrine sweat glands and 
      apocrine sweat glands by immunofluorescence staining. The results showed that K7, 
      K18, K19, Foxa1, GCDFP-15 and MUC-1 were expressed in both apocrine and eccrine 
      sweat glands, CD15 and APOD were only expressed in apocrine sweat glands, and 
      CAII, NKCC1 and En1 were only expressed in eccrine sweat glands. We conclude that 
      CD15 and APOD can serve as specific markers for apocrine sweat glands, while 
      CAII, NKCC1 and En1 can serve as specific markers for eccrine sweat glands to 
      differentiate the two sweat glands.
FAU - Cao, Manxiu
AU  - Cao M
AD  - Department of Wound Repair and Dermatologic Surgery, Taihe Hospital, Hubei 
      University of Medicine, Shiyan, Hubei. 2945190536@qq.com.
FAU - Zhang, Lei
AU  - Zhang L
AD  - Department of Mental Health, Southern University of Science and Technology 
      Hospital, Southern University of Science and Technology School of Medicine, 
      Shenzhen, Guangdong. zhanglei1051@126.com.
FAU - Chen, Jiaqi
AU  - Chen J
AD  - Department of Wound Repair and Dermatologic Surgery, Taihe Hospital, Hubei 
      University of Medicine, Shiyan, Hubei. 2324187061@qq.com.
FAU - Wang, Cangyu
AU  - Wang C
AD  - Department of Wound Repair and Dermatologic Surgery, Taihe Hospital, Hubei 
      University of Medicine, Shiyan, Hubei. wangcangyu888@qq.com.
FAU - Zhao, Junhong
AU  - Zhao J
AD  - Department of Wound Repair and Dermatologic Surgery, Taihe Hospital, Hubei 
      University of Medicine, Shiyan, Hubei. jhong0226@163.com.
FAU - Liu, Xiang
AU  - Liu X
AD  - Department of Wound Repair and Dermatologic Surgery, Taihe Hospital, Hubei 
      University of Medicine, Shiyan, Hubei. 414742227@qq.com.
FAU - Yan, Yongjing
AU  - Yan Y
AD  - Department of Wound Repair and Dermatologic Surgery, Taihe Hospital, Hubei 
      University of Medicine, Shiyan, Hubei. 973063451@qq.com.
FAU - Tang, Yue
AU  - Tang Y
AD  - Department of Wound Repair and Dermatologic Surgery, Taihe Hospital, Hubei 
      University of Medicine, Shiyan, Hubei . tangyue_yy@163.com.
FAU - Chen, Zixiu
AU  - Chen Z
AD  - Department of Wound Repair and Dermatologic Surgery, Taihe Hospital, Hubei 
      University of Medicine, Shiyan, Hubei. chen_zixiu@126.com.
FAU - Li, Haihong
AU  - Li H
AD  - Department of Wound Repair and Dermatologic Surgery, Taihe Hospital, Hubei 
      University of Medicine, Shiyan, Hubei. lihaihong1051@126.com.
LA  - eng
PT  - Journal Article
DEP - 20230102
PL  - Italy
TA  - Eur J Histochem
JT  - European journal of histochemistry : EJH
JID - 9207930
RN  - 0 (K-18 conjugate)
SB  - IM
MH  - Humans
MH  - *Body Odor
MH  - *Eccrine Glands/metabolism
MH  - Apocrine Glands
MH  - Gene Expression Regulation
PMC - PMC9827426
EDAT- 2022/12/23 06:00
MHDA- 2022/12/24 06:00
PMCR- 2022/12/22
CRDT- 2022/12/22 05:42
PHST- 2022/09/18 00:00 [received]
PHST- 2022/11/29 00:00 [accepted]
PHST- 2022/12/22 05:42 [entrez]
PHST- 2022/12/23 06:00 [pubmed]
PHST- 2022/12/24 06:00 [medline]
PHST- 2022/12/22 00:00 [pmc-release]
AID - 10.4081/ejh.2023.3559 [doi]
PST - epublish
SO  - Eur J Histochem. 2023 Jan 2;67(1):3559. doi: 10.4081/ejh.2023.3559.