PMID- 36547429 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20230308 IS - 2308-3425 (Electronic) IS - 2308-3425 (Linking) VI - 9 IP - 12 DP - 2022 Dec 2 TI - Age-Related Mortality in STEMI Patients: Insight from One Year of HUB Centre Experience during the Pandemic. LID - 10.3390/jcdd9120432 [doi] LID - 432 AB - Background: Old patients have a poor prognosis when affected by ST elevation myocardial infarction (STEMI). The aim of our study was to evaluate the impact of age on acute and mid-term mortality in STEMI patients over one year in the pandemic period. Methods: we collected data on 283 STEMI patients divided into three groups according to age (not old, "Not-O", /=85 y/o). Results: the three groups did not differ in their clinical or procedural characteristics. The Very-O patients had a significantly increased incidence of in-hospital MACE (35%), mortality (30.0%), and percentage of cardiac death (25.0%). The only two independent predictors of in-hospital mortality were the ejection fraction (EF) [OR:0.902 (95% CI) 0.868-0.938; p < 0.0001] and COVID-19 infection [OR:3.177 (95% CI) 1.212-8.331; p = 0.019]. At follow-up (430 +/- days), the survival rates were decreased significatively among the age groups (Not-O 2.9% vs. O 14.8% vs. Very-O 28.6%; p < 0.0001), and the only two independent predictors of the follow-up mortality were the EF [OR:0.935 (95% CI) 0.891-0.982; p = 0.007] and age [OR:1.06 (95% CI) 1.018-1.110; p = 0.019]. Conclusions: in very old patients, all the accessory procedures that may be performed should be accurately and independently weighed up in terms of the risk-benefit balance and the real impact on the quality of life because of the poor mid-term prognosis. FAU - Tumminello, Gabriele AU - Tumminello G AUID- ORCID: 0000-0003-3121-8400 AD - Department of Cardio-Toracic-Vascular Diseases, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Via Francesco Sforza, 35, 20122 Milano, Italy. FAU - D'Errico, Andrea AU - D'Errico A AD - Department of Cardio-Toracic-Vascular Diseases, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Via Francesco Sforza, 35, 20122 Milano, Italy. FAU - Maruccio, Alessio AU - Maruccio A AD - Department of Cardio-Toracic-Vascular Diseases, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Via Francesco Sforza, 35, 20122 Milano, Italy. FAU - Gentile, Domitilla AU - Gentile D AD - Cardiovascular Research Team, San Carlo Clinic, Via Bertola, 3, 20026 Novate Milanese, Italy. FAU - Barbieri, Lucia AU - Barbieri L AUID- ORCID: 0000-0001-8982-4898 AD - Department of Cardio-Toracic-Vascular Diseases, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Via Francesco Sforza, 35, 20122 Milano, Italy. AD - Department of Clinical Sciences and Community Health, University of Milan, 20122 Milan, Italy. FAU - Carugo, Stefano AU - Carugo S AUID- ORCID: 0000-0002-5166-0899 AD - Department of Cardio-Toracic-Vascular Diseases, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Via Francesco Sforza, 35, 20122 Milano, Italy. AD - Department of Clinical Sciences and Community Health, University of Milan, 20122 Milan, Italy. LA - eng PT - Journal Article DEP - 20221202 PL - Switzerland TA - J Cardiovasc Dev Dis JT - Journal of cardiovascular development and disease JID - 101651414 PMC - PMC9781871 OTO - NOTNLM OT - COVID-19 OT - STEMI OT - age COIS- The authors declare no conflict of interest. EDAT- 2022/12/23 06:00 MHDA- 2022/12/23 06:01 PMCR- 2022/12/02 CRDT- 2022/12/22 10:53 PHST- 2022/10/05 00:00 [received] PHST- 2022/11/21 00:00 [revised] PHST- 2022/11/30 00:00 [accepted] PHST- 2022/12/22 10:53 [entrez] PHST- 2022/12/23 06:00 [pubmed] PHST- 2022/12/23 06:01 [medline] PHST- 2022/12/02 00:00 [pmc-release] AID - jcdd9120432 [pii] AID - jcdd-09-00432 [pii] AID - 10.3390/jcdd9120432 [doi] PST - epublish SO - J Cardiovasc Dev Dis. 2022 Dec 2;9(12):432. doi: 10.3390/jcdd9120432.