PMID- 36547832 OWN - NLM STAT- MEDLINE DCOM- 20230329 LR - 20230329 IS - 1614-7499 (Electronic) IS - 0944-1344 (Linking) VI - 30 IP - 13 DP - 2023 Mar TI - Selenium attenuates the association of co-exposure to arsenic, cadmium, and lead with cognitive function among Chinese community-dwelling older adults. PG - 36377-36391 LID - 10.1007/s11356-022-24783-y [doi] AB - The effects of interactions between the toxic and essential metal mixtures on cognitive function are poorly understood. This study aims to identify the joint association of arsenic (As), cadmium (Cd), and lead (Pb) with cognitive function in older adults and the moderating role of selenium (Se), zinc (Zn), and copper (Cu) in this association. This study included 1000 community-dwelling older adults. Cognitive function was assessed by the Mini-Mental State Examination (MMSE). Blood concentrations of As, Cd, Pb, Se, Zn, and Cu were measured using inductively coupled plasma mass spectrometry. Linear regression and Bayesian kernel machine regression (BKMR) models were applied to assess the individual and joint associations of As, Cd, and Pb with cognitive function and to examine whether Se, Zn, and Cu (individually and as a mixture) modified these associations. In the adjusted single-metal models, both Cd (beta = - 0.37, 95% CI: - 0.73 to - 0.01) and Pb (beta = - 0.44, 95% CI: - 0.86 to - 0.02) were associated with MMSE scores, while Se (beta = 0.71, 95% CI: 0.30 to 1.13) exhibited a positive relationship with MMSE scores. Univariate exposure-response functions from BKMR models showed similar results. Moreover, the toxic metal mixture (As, Cd, and Pb) exhibited a significant negative association with MMSE scores in a dose-response pattern, with Pb being the greatest contributor within the mixture. The negative association of Pb alone or the toxic metal mixture with MMSE scores became weaker at higher concentrations of Se within its normal range, especially when Se levels were greater than the median (89.18 mug/L). Our findings support that Se can attenuate the negative associations of exposure to single Pb or the As, Cd, and Pb mixtures with cognitive function. Future prospective studies are needed to replicate our findings. CI - (c) 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. FAU - Cheng, Bei-Jing AU - Cheng BJ AD - School of Public Health, Anhui Medical University, Hefei, 230032, Anhui, China. AD - Anhui Provincial Key Laboratory of Population Health and Aristogenics, Hefei, 230032, Anhui, China. AD - Key Laboratory of Environmental Medicine Engineering, Ministry of Education, Southeast University, Nanjing, 210009, Jiangsu, China. FAU - Sheng, Jie AU - Sheng J AD - School of Public Health, Anhui Medical University, Hefei, 230032, Anhui, China. AD - Anhui Provincial Key Laboratory of Population Health and Aristogenics, Hefei, 230032, Anhui, China. FAU - Wang, Hong-Li AU - Wang HL AD - School of Public Health, Anhui Medical University, Hefei, 230032, Anhui, China. FAU - Wang, Yuan AU - Wang Y AD - School of Public Health, Anhui Medical University, Hefei, 230032, Anhui, China. FAU - Cao, Hong-Juan AU - Cao HJ AD - Lu'an Center for Disease Control and Prevention, Lu'an, 237008, Anhui, China. FAU - Li, Xiu-De AU - Li XD AD - School of Public Health, Anhui Medical University, Hefei, 230032, Anhui, China. AD - Lu'an Center for Disease Control and Prevention, Lu'an, 237008, Anhui, China. FAU - Zhou, Ting-Ting AU - Zhou TT AD - School of Public Health, Anhui Medical University, Hefei, 230032, Anhui, China. AD - Hefei Center for Disease Control and Prevention, Hefei, 230051, Anhui, China. FAU - Meng, Xiang-Long AU - Meng XL AD - School of Public Health, Anhui Medical University, Hefei, 230032, Anhui, China. FAU - Nie, Huan-Huan AU - Nie HH AD - School of Public Health, Anhui Medical University, Hefei, 230032, Anhui, China. FAU - Wang, Su-Fang AU - Wang SF AD - School of Public Health, Anhui Medical University, Hefei, 230032, Anhui, China. FAU - Zhang, Dong-Mei AU - Zhang DM AD - School of Health Services Management, Anhui Medical University, Hefei, 230032, Anhui, China. FAU - Chen, Gui-Mei AU - Chen GM AD - School of Health Services Management, Anhui Medical University, Hefei, 230032, Anhui, China. FAU - Tao, Fang-Biao AU - Tao FB AD - School of Public Health, Anhui Medical University, Hefei, 230032, Anhui, China. AD - Anhui Provincial Key Laboratory of Population Health and Aristogenics, Hefei, 230032, Anhui, China. FAU - Yang, Lin-Sheng AU - Yang LS AUID- ORCID: 0000-0002-8025-8022 AD - School of Public Health, Anhui Medical University, Hefei, 230032, Anhui, China. yanglinsheng@ahmu.edu.cn. AD - Anhui Provincial Key Laboratory of Population Health and Aristogenics, Hefei, 230032, Anhui, China. yanglinsheng@ahmu.edu.cn. LA - eng GR - 2016YFC1305900/the National Key R&D Program of China/ GR - 0303011224/Major Projects on College Leading Talent Team Introduced of Anhui/ GR - KJ2017A189/the Key Scientific Research Fund of Anhui Provincial Education Department/ GR - Xj201525/Grants for Scientific Research of BSKY from Anhui Medical University/ PT - Journal Article DEP - 20221222 PL - Germany TA - Environ Sci Pollut Res Int JT - Environmental science and pollution research international JID - 9441769 RN - N712M78A8G (Arsenic) RN - 00BH33GNGH (Cadmium) RN - 2P299V784P (Lead) RN - 0 (Metals, Heavy) RN - H6241UJ22B (Selenium) SB - IM MH - Aged MH - Humans MH - Arsenic/toxicity MH - Bayes Theorem MH - Cadmium/toxicity MH - Cognition MH - East Asian People MH - Heavy Metal Poisoning MH - Lead/toxicity MH - *Metals, Heavy/toxicity MH - *Selenium/pharmacology OTO - NOTNLM OT - Cognitive function OT - Modification OT - Older adults OT - Selenium OT - Toxic metals EDAT- 2022/12/23 06:00 MHDA- 2023/03/29 06:05 CRDT- 2022/12/22 11:21 PHST- 2022/09/23 00:00 [received] PHST- 2022/12/12 00:00 [accepted] PHST- 2023/03/29 06:05 [medline] PHST- 2022/12/23 06:00 [pubmed] PHST- 2022/12/22 11:21 [entrez] AID - 10.1007/s11356-022-24783-y [pii] AID - 10.1007/s11356-022-24783-y [doi] PST - ppublish SO - Environ Sci Pollut Res Int. 2023 Mar;30(13):36377-36391. doi: 10.1007/s11356-022-24783-y. Epub 2022 Dec 22.