PMID- 36549450
OWN - NLM
STAT- MEDLINE
DCOM- 20230117
LR  - 20230117
IS  - 1873-6424 (Electronic)
IS  - 0269-7491 (Linking)
VI  - 318
DP  - 2023 Feb 1
TI  - Azole pesticide products and their hepatic metabolites cause endocrine disrupting 
      potential by suppressing the homo-dimerization of human estrogen receptor alpha.
PG  - 120894
LID - S0269-7491(22)02109-1 [pii]
LID - 10.1016/j.envpol.2022.120894 [doi]
AB  - We selected azole pesticides products that are managed by setting maximum residue 
      limits (MRLs) in the Republic of Korea and describe the estrogen receptor (ER) 
      alpha-related negative effect to endocrine system using in vitro Organization for 
      Economic Cooperation and Development performance-based test guideline. No azoles 
      were found to be an ERalpha agonist. Conversely, three azoles (bitertanol, 
      cafenstrole, and tebufenpyrad) were determined to be ERalpha antagonists. In 
      addition, the ERalpha antagonistic activities of bitertanol, cafenstrole, and 
      tebufenpyrad were not significantly perturbed in the existence of phase I 
      (hydroxylation, dealkylation, oxidation or reduction) and phase II (conjugation). 
      Regarding the mechanism underlying their ERalpha-mediated endocrine disrupting 
      potentials, ERalpha proteins cannot be translocated to the nucleus by suppressing the 
      dimerization of ERalpha in the cytoplasm by bitertanol, cafenstrole, and 
      tebufenpyrad. These data indicated that azole pesticide products show the 
      capability to interfere the ERalpha-related human endocrine system. Furthermore, we 
      identified the mechanism of ERalpha-mediated endocrine disrupting by azole 
      insecticide products through this study.
CI  - Copyright (c) 2022 Elsevier Ltd. All rights reserved.
FAU - Jung, Da-Woon
AU  - Jung DW
AD  - Department of Food Science and Biotechnology, Chung-Ang University, Anseong, 
      17546, Republic of Korea.
FAU - Jeong, Da-Hyun
AU  - Jeong DH
AD  - Department of Food Science and Biotechnology, Chung-Ang University, Anseong, 
      17546, Republic of Korea.
FAU - Lee, Hee-Seok
AU  - Lee HS
AD  - Department of Food Science and Biotechnology, Chung-Ang University, Anseong, 
      17546, Republic of Korea; Department of Food Safety and Regulatory Science, 
      Chung-Ang University, Anseong, 17546, Republic of Korea. Electronic address: 
      hslee0515@cau.ac.kr.
LA  - eng
PT  - Journal Article
DEP - 20221219
PL  - England
TA  - Environ Pollut
JT  - Environmental pollution (Barking, Essex : 1987)
JID - 8804476
RN  - 125306-83-4 (cafenstrole)
RN  - 0 (Estrogen Receptor alpha)
RN  - GR7Z3Z59G9 (bitertanol)
RN  - 0 (Azoles)
RN  - 0 (Receptors, Estrogen)
RN  - 0 (Pesticides)
RN  - 0 (Estrogen Receptor beta)
SB  - IM
MH  - Humans
MH  - *Estrogen Receptor alpha/metabolism
MH  - Dimerization
MH  - Azoles/toxicity
MH  - Receptors, Estrogen/metabolism
MH  - *Pesticides
MH  - Endocrine System
MH  - Estrogen Receptor beta/metabolism
OTO - NOTNLM
OT  - Antagonist
OT  - Azole
OT  - Dimerization
OT  - Estrogen receptor alpha
OT  - OECD test Guideline
COIS- Declaration of competing interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2022/12/23 06:00
MHDA- 2023/01/18 06:00
CRDT- 2022/12/22 19:14
PHST- 2022/09/16 00:00 [received]
PHST- 2022/11/12 00:00 [revised]
PHST- 2022/12/15 00:00 [accepted]
PHST- 2022/12/23 06:00 [pubmed]
PHST- 2023/01/18 06:00 [medline]
PHST- 2022/12/22 19:14 [entrez]
AID - S0269-7491(22)02109-1 [pii]
AID - 10.1016/j.envpol.2022.120894 [doi]
PST - ppublish
SO  - Environ Pollut. 2023 Feb 1;318:120894. doi: 10.1016/j.envpol.2022.120894. Epub 
      2022 Dec 19.