PMID- 36550385 OWN - NLM STAT- MEDLINE DCOM- 20230202 LR - 20230202 IS - 1435-5604 (Electronic) IS - 0914-8779 (Linking) VI - 41 IP - 1 DP - 2023 Jan TI - Peripheral quantitative computed tomography-derived bone parameters in men with impaired fasting glucose and diabetes. PG - 131-142 LID - 10.1007/s00774-022-01389-5 [doi] AB - INTRODUCTION: Individuals with type 2 diabetes mellitus (T2DM) are at higher risk of fracture, but paradoxically do not have reduced bone mineral density. We investigated associations between peripheral quantitative computed tomography (pQCT) and glycaemia status. MATERIALS AND METHODS: Participants were men (n = 354, age 33-92 year) from the Geelong Osteoporosis Study. Diabetes was defined by fasting plasma glucose (FPG) >/= 7.0 mmol/L, self-report of diabetes and/or antihyperglycaemic medication use and impaired fasting glucose (IFG) as FPG 5.6-6.9 mmol/L. Bone measures were derived using pQCT (XCT2000) at 4% and 66% radial and tibial sites. Linear regression was used, adjusting for age, body mass index and socio-economic status. RESULTS: At the 4% site, men with T2DM had lower adjusted bone total area, trabecular area and cortical area at the radius (all - 6.2%) and tibia (all - 6.4%) compared to normoglycaemia. Cortical density was higher for T2DM at the radius (+ 5.8%) and tibia (+ 8.0%), as well as adjusted total bone density at the tibial site (+ 6.1%). At the 66% site, adjusted total bone area and polar stress strain index were lower for T2DM at the radius (- 4.3% and - 8.0%). Total density was also higher for T2DM (+ 1.2%). Only cortical density at the 4% tibial site was different between IFG and normoglycaemia in adjusted analyses (+ 4.5%). CONCLUSION: Men with T2DM had lower total bone area, trabecular area, cortical area and polar stress strain index than the other two groups; however, total density and cortical density were higher. Only one difference was observed between IFG and normoglycaemia; increased tibial cortical density. CI - (c) 2022. The Japanese Society Bone and Mineral Research. FAU - Holloway-Kew, Kara L AU - Holloway-Kew KL AUID- ORCID: 0000-0001-5064-2990 AD - IMPACT-the Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Deakin University, Level 3 (Barwon Health), PO Box 281, Geelong, , VIC, 3220, Australia. k.holloway@deakin.edu.au. FAU - Anderson, Kara B AU - Anderson KB AUID- ORCID: 0000-0002-7798-180X AD - IMPACT-the Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Deakin University, Level 3 (Barwon Health), PO Box 281, Geelong, , VIC, 3220, Australia. FAU - Tembo, Monica C AU - Tembo MC AUID- ORCID: 0000-0003-1210-2437 AD - IMPACT-the Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Deakin University, Level 3 (Barwon Health), PO Box 281, Geelong, , VIC, 3220, Australia. FAU - Sui, Sophia X AU - Sui SX AUID- ORCID: 0000-0001-6388-1261 AD - IMPACT-the Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Deakin University, Level 3 (Barwon Health), PO Box 281, Geelong, , VIC, 3220, Australia. FAU - Harland, Jacob W AU - Harland JW AD - IMPACT-the Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Deakin University, Level 3 (Barwon Health), PO Box 281, Geelong, , VIC, 3220, Australia. FAU - Hyde, Natalie K AU - Hyde NK AUID- ORCID: 0000-0002-0693-2904 AD - IMPACT-the Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Deakin University, Level 3 (Barwon Health), PO Box 281, Geelong, , VIC, 3220, Australia. FAU - Kotowicz, Mark A AU - Kotowicz MA AUID- ORCID: 0000-0002-8094-1411 AD - IMPACT-the Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Deakin University, Level 3 (Barwon Health), PO Box 281, Geelong, , VIC, 3220, Australia. AD - Barwon Health, Geelong, Australia. AD - Department of Medicine-Western Health, The University of Melbourne, St Albans, Australia. FAU - Pasco, Julie A AU - Pasco JA AUID- ORCID: 0000-0002-8968-4714 AD - IMPACT-the Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Deakin University, Level 3 (Barwon Health), PO Box 281, Geelong, , VIC, 3220, Australia. AD - Barwon Health, Geelong, Australia. AD - Department of Medicine-Western Health, The University of Melbourne, St Albans, Australia. AD - Department of Epidemiology and Preventive Medicine, Monash University, Prahran, Australia. LA - eng GR - 299831/National Health and Medical Research Council/ GR - 628582/National Health and Medical Research Council/ GR - Alfred Deakin Postdoctoral Research Fellowship/Deakin University/ GR - Australian Government Research Training Program Scholarship/Deakin University/ GR - Deakin Postgraduate Scholarship/Deakin University/ GR - Dean's Research Postdoctoral Fellowship/Deakin University/ GR - Deakin University Postgraduate Research Scholarship/Deakin University/ PT - Journal Article DEP - 20221223 PL - Japan TA - J Bone Miner Metab JT - Journal of bone and mineral metabolism JID - 9436705 RN - IY9XDZ35W2 (Glucose) SB - IM MH - Male MH - Humans MH - Adult MH - Middle Aged MH - Aged MH - Aged, 80 and over MH - Female MH - *Diabetes Mellitus, Type 2 MH - Bone and Bones MH - Bone Density MH - Radius/diagnostic imaging MH - Tibia/diagnostic imaging MH - Fasting MH - Tomography MH - Glucose OTO - NOTNLM OT - Impaired fasting glucose OT - Men OT - Peripheral quantitative computed tomography OT - Type 2 diabetes EDAT- 2022/12/23 06:00 MHDA- 2023/02/03 06:00 CRDT- 2022/12/22 23:42 PHST- 2022/08/17 00:00 [received] PHST- 2022/11/13 00:00 [accepted] PHST- 2022/12/23 06:00 [pubmed] PHST- 2023/02/03 06:00 [medline] PHST- 2022/12/22 23:42 [entrez] AID - 10.1007/s00774-022-01389-5 [pii] AID - 10.1007/s00774-022-01389-5 [doi] PST - ppublish SO - J Bone Miner Metab. 2023 Jan;41(1):131-142. doi: 10.1007/s00774-022-01389-5. Epub 2022 Dec 23.