PMID- 36550625
OWN - NLM
STAT- MEDLINE
DCOM- 20230314
LR  - 20230412
IS  - 1613-4133 (Electronic)
IS  - 1613-4125 (Linking)
VI  - 67
IP  - 5
DP  - 2023 Mar
TI  - Effects of Allergen-Specific and Non-Specific AGEs on the Allergenicity of 
      Ovalbumin in a Mouse Model of Food Allergy.
PG  - e2200221
LID - 10.1002/mnfr.202200221 [doi]
AB  - SCOPE: Epidemiologic studies suggest a link between the incidence of food allergy 
      and the consumption of dietary advanced glycation end-products (AGEs). However, 
      the pathogenic role of dietary AGEs in food allergy is largely unknown. This 
      study aims to investigate the effect of allergen-specific and non-specific AGEs 
      on the allergenic manifestation of ovalbumin (OVA), a typical food allergen in 
      vivo. METHODS AND RESULTS: OVA is glycated by methylglyoxal to prepare 
      allergen-specific AGEs (i.e., OVA-AGE), and a standard AIN-93G diet is heated to 
      obtain allergen-non-specific AGEs. A BALB/c mouse model orally sensitizes to OVA 
      with different forms of AGEs is established and the outcomes are measured as 
      clinical signs, specific antibodies, type-2/type-2 cytokines, immune cell 
      subpopulations, intestinal barrier function, and gut microbiota (GM) composition. 
      The OVA-AGE which has a lower immunoglobulin E (IgE)-binding level in vitro does 
      not reduce the allergenicity of OVA but promotes a stronger T helper 2 cells 
      (Th2)-response than native OVA in vivo. Both forms of AGEs up-regulate the 
      expression of splenic RAGE and aggravate the destruction of gut barrier and GM 
      dysbiosis, especially when exposes to non-relevant AGEs. CONCLUSION: This study 
      highlights the role of dietary AGEs in food allergy and helps to understand the 
      biological consequences of immune-toxic compounds in modern diet.
CI  - (c) 2022 Wiley-VCH GmbH.
FAU - Yu, Gang
AU  - Yu G
AD  - Food Safety Key Laboratory of Zhejiang Province, School of Food Science and 
      Biotechnology, Zhejiang Gongshang University, Hangzhou, 310018, P. R. China.
FAU - Zhang, Qiaozhi
AU  - Zhang Q
AD  - Food Safety Key Laboratory of Zhejiang Province, School of Food Science and 
      Biotechnology, Zhejiang Gongshang University, Hangzhou, 310018, P. R. China.
FAU - Li, Huatao
AU  - Li H
AD  - Food Safety Key Laboratory of Zhejiang Province, School of Food Science and 
      Biotechnology, Zhejiang Gongshang University, Hangzhou, 310018, P. R. China.
FAU - Wang, Yanbo
AU  - Wang Y
AD  - Food Safety Key Laboratory of Zhejiang Province, School of Food Science and 
      Biotechnology, Zhejiang Gongshang University, Hangzhou, 310018, P. R. China.
FAU - Sheng, Huadong
AU  - Sheng H
AD  - National Pre-packaged Food Quality Supervision and Inspection Center (Zhejiang), 
      Zhejiang Fangyuan Test Group Co. LTD., Hangzhou, 310018, P. R. China.
FAU - Zhang, Shuifeng
AU  - Zhang S
AD  - National Pre-packaged Food Quality Supervision and Inspection Center (Zhejiang), 
      Zhejiang Fangyuan Test Group Co. LTD., Hangzhou, 310018, P. R. China.
FAU - Fu, Linglin
AU  - Fu L
AD  - Food Safety Key Laboratory of Zhejiang Province, School of Food Science and 
      Biotechnology, Zhejiang Gongshang University, Hangzhou, 310018, P. R. China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20230126
PL  - Germany
TA  - Mol Nutr Food Res
JT  - Molecular nutrition & food research
JID - 101231818
RN  - 9006-59-1 (Ovalbumin)
RN  - 0 (Allergens)
RN  - 0 (Cytokines)
RN  - 0 (Glycation End Products, Advanced)
SB  - IM
MH  - Mice
MH  - Animals
MH  - Ovalbumin
MH  - *Allergens
MH  - *Food Hypersensitivity
MH  - Cytokines/metabolism
MH  - Glycation End Products, Advanced
MH  - Mice, Inbred BALB C
MH  - Disease Models, Animal
OTO - NOTNLM
OT  - advanced glycation end-products
OT  - food allergy
OT  - gut microbiota
OT  - immune response
OT  - intestinal barrier function
EDAT- 2022/12/24 06:00
MHDA- 2023/03/15 06:00
CRDT- 2022/12/23 00:03
PHST- 2022/12/24 06:00 [pubmed]
PHST- 2023/03/15 06:00 [medline]
PHST- 2022/12/23 00:03 [entrez]
AID - 10.1002/mnfr.202200221 [doi]
PST - ppublish
SO  - Mol Nutr Food Res. 2023 Mar;67(5):e2200221. doi: 10.1002/mnfr.202200221. Epub 
      2023 Jan 26.