PMID- 36550654
OWN - NLM
STAT- MEDLINE
DCOM- 20221226
LR  - 20221226
IS  - 1819-2718 (Electronic)
IS  - 1025-9589 (Linking)
VI  - 34(Suppl 1)
IP  - 4
DP  - 2022 Oct-Dec
TI  - Correlation Of Glomerular Filtration Rate (Gfr) Estimation Formulae With Measured 
      Gfr In Pediatric Oncology Patients.
PG  - S964-S968
LID - 10.55519/JAMC-04-S4-10133 [doi]
AB  - BACKGROUND: In patients with malignancy accurate assessment of renal function is 
      important for administration of chemotherapeutic medicines. Measurement of GFR by 
      inulin, EDTA clearance, iohexol and 24 hrs urinary creatinine clearance (Crcl) is 
      cumbersome so creatinine based GFR formulas have been developed for assessment of 
      kidney function and there are variety of GFR formulas available for clinical use. 
      Objective was to determine the correlation of estimated GFR by creatinine-based 
      estimation formulae with measured GFR by 24-hours creatinine clearance. METHODS: 
      A cross sectional study was conducted in which all patients who underwent 
      measured GFR (mGFR) assessment at Oncology Unit of NICH between 1st January to 
      31st December 2019 were enrolled in the study. Estimated Glomerular filtration 
      rate (eGFR) of all these patients was calculated by three formulae Original 
      Schwartz (OS), Updated Schwartz (US) and simple height independent equation 
      (SHID). Correlation was made with mGFR by Crcl taken as gold standard using 
      Pearson's correlation and Linear regression analysis. Bland Altman analysis was 
      also done to see the agreement between eGFR with mGFR. RESULTS: Total sixty (60) 
      patients were enrolled with mean age of 8.2+/-3.6 years. All three eGFR formulae 
      exhibited a statistically significant positive correlation with mGFR (p-value 
      <0.01). Linear regression analysis also showed a statistically significant 
      relation between mGFR and eGFRs however, the developed regression models for all 
      three formulae showed a low R2 values. Bland-altman analysis revealed that useful 
      level of agreement does not exist between mGFR and eGFR by OS however, SHID and 
      US were found to be in agreement with mGFR by Crcl. CONCLUSION: SHID and US 
      equations give a good estimate of GFR and may be used in children with 
      malignancies to estimate GFR.
FAU - Pervez, Shazia
AU  - Pervez S
AD  - National Institute of Child Health Karachi, Pakistan.
FAU - Anjum, Misbah
AU  - Anjum M
AD  - National Institute of Child Health Karachi, Pakistan.
FAU - Bibi, Safia
AU  - Bibi S
AD  - National Institute of Child Health Karachi, Pakistan.
FAU - Kulsoom, Shazia
AU  - Kulsoom S
AD  - National Institute of Child Health Karachi, Pakistan.
FAU - Hussain, Wajid
AU  - Hussain W
AD  - National Institute of Child Health Karachi, Pakistan.
FAU - Naeem, Bilquis
AU  - Naeem B
AD  - National Institute of Child Health Karachi, Pakistan.
LA  - eng
PT  - Journal Article
PL  - Pakistan
TA  - J Ayub Med Coll Abbottabad
JT  - Journal of Ayub Medical College, Abbottabad : JAMC
JID - 8910750
RN  - AYI8EX34EU (Creatinine)
SB  - IM
MH  - Child
MH  - Humans
MH  - Child, Preschool
MH  - Glomerular Filtration Rate
MH  - Creatinine
MH  - Cross-Sectional Studies
MH  - Kidney Function Tests
MH  - *Neoplasms
OTO - NOTNLM
OT  - Cancer Children
OT  - GFR; Estimation formulae
EDAT- 2022/12/24 06:00
MHDA- 2022/12/27 06:00
CRDT- 2022/12/23 00:32
PHST- 2022/12/23 00:32 [entrez]
PHST- 2022/12/24 06:00 [pubmed]
PHST- 2022/12/27 06:00 [medline]
AID - 10133/3441 [pii]
AID - 10.55519/JAMC-04-S4-10133 [doi]
PST - ppublish
SO  - J Ayub Med Coll Abbottabad. 2022 Oct-Dec;34(Suppl 1)(4):S964-S968. doi: 
      10.55519/JAMC-04-S4-10133.