PMID- 36550881
OWN - NLM
STAT- MEDLINE
DCOM- 20221230
LR  - 20230103
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Print)
IS  - 0025-7974 (Linking)
VI  - 101
IP  - 50
DP  - 2022 Dec 16
TI  - Traditional Chinese medicine body constitution predicts new-onset diabetic 
      albuminuria in patients with type 2 diabetes: Taichung diabetic body constitution 
      prospective cohort study.
PG  - e32342
LID - 10.1097/MD.0000000000032342 [doi]
LID - e32342
AB  - This prospective cohort study explored whether body constitution (BC) 
      independently predicts new-onset albuminuria in persons with type 2 diabetes 
      mellitus (T2DM) enrolled in the diabetes care management program (DCMP) of a 
      medical center, providing evidence of integrating traditional Chinese medicine 
      into DCMP for improving care quality. Persons with T2DM (n = 426) originally 
      without albuminuria enrolled in DCMP were recruited in 2010 and were then 
      followed up to 2015 for detecting new-onset albuminuria. The participants 
      received urinalysis and blood test annually. Albuminuria was determined by an 
      elevated urinary albumin/creatinine ratio (>/= 30 microg/mg), and poor glucose control 
      was defined as Glycosylated hemoglobin above or equal to 7%. BC type (Yin 
      deficiency, Yang deficiency, and phlegm stasis) was assessed using a 
      well-validated body constitution questionnaire at baseline. Risk factors for 
      albuminuria (sociodemographic factors, diabetes history, lifestyle behaviors, 
      lipid profile, blood pressure, and kidney function) were also recorded. Hazard 
      ratios (HR) of albuminuria for BC were estimated using multivariate Cox 
      proportional hazards model. During the 4-year follow-up period, albuminuria 
      occurred in 30.5% of participants (n = 130). The HR indicated that Yin deficiency 
      was significantly associated with an increased risk of new-onset albuminuria in 
      persons with T2DM and good glucose control after adjustment for other risk 
      factors (HR = 2.09; 95% confidence interval = 1.05-4.17, P = .04), but not in 
      those with poor glucose control. In persons with T2DM and poor glucose control, 
      phlegm stasis was also significantly associated with a higher risk of albuminuria 
      (2.26; 1.03-4.94, P = .04) after multivariate adjustment, but not in those with 
      good glucose control. In addition to already-known risk factors, BC is an 
      independent and significant factor associated with new-onset albuminuria in 
      persons with T2DM. Our results imply Yin deficiency and phlegm stasis interacting 
      with glucose control status may affect new-onset albuminuria in persons with 
      T2DM.
CI  - Copyright (c) 2022 the Author(s). Published by Wolters Kluwer Health, Inc.
FAU - Lee, Cheng-Hung
AU  - Lee CH
AD  - Department of Traditional Chinese Medicine, Taichung Veterans General Hospital, 
      Taichung, Taiwan.
AD  - Department of Post-Baccalaureate Medicine, College of Medicine, National Chung 
      Hsing University, Taichung, Taiwan.
AD  - Center for General Education of Tunghai University, Tunghai University, Taichung, 
      Taiwan.
FAU - Tsai, Chia-I
AU  - Tsai CI
AD  - Department of Traditional Chinese Medicine, Taichung Veterans General Hospital, 
      Taichung, Taiwan.
AD  - Department of Post-Baccalaureate Medicine, College of Medicine, National Chung 
      Hsing University, Taichung, Taiwan.
AD  - Center for General Education of Tunghai University, Tunghai University, Taichung, 
      Taiwan.
FAU - Su, Yi-Chang
AU  - Su YC
AD  - National Research Institute of Chinese Medicine, Ministry of Health and Welfare, 
      Taipei, Taiwan.
FAU - Lin, Shih-Yi
AU  - Lin SY
AD  - Division of Endocrinology and Metabolism, Department of Internal Medicine, 
      Taichung Veterans General Hospital, Taichung, Taiwan.
AD  - Center for Geriatrics and Gerontology, Taichung Veterans General Hospital, 
      Taichung, Taiwan.
AD  - School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.
FAU - Lee, I-Te
AU  - Lee IT
AD  - Division of Endocrinology and Metabolism, Department of Internal Medicine, 
      Taichung Veterans General Hospital, Taichung, Taiwan.
AD  - School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.
AD  - School of Medicine, Chung Shan Medical University, Taichung, Taiwan.
FAU - Li, Tsai-Chung
AU  - Li TC
AUID- ORCID: 0000-0002-3346-7462
AD  - Department of Public Health, College of Public Health, China Medical University, 
      Taichung, Taiwan.
AD  - Department of Healthcare Administration, College of Medical and Health Science, 
      Asia University, Taichung, Taiwan.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
RN  - 0 (Blood Glucose)
RN  - 1032-65-1 (Deoxycytidine Monophosphate)
SB  - IM
MH  - Humans
MH  - Albuminuria/etiology
MH  - Blood Glucose
MH  - Body Constitution
MH  - Deoxycytidine Monophosphate
MH  - *Diabetes Mellitus, Type 2/complications
MH  - *Diabetic Nephropathies
MH  - Medicine, Chinese Traditional/methods
MH  - Prospective Studies
MH  - Yin Deficiency
PMC - PMC9771319
COIS- The authors have no funding and conflicts of interest to disclose.
EDAT- 2022/12/24 06:00
MHDA- 2022/12/27 06:00
PMCR- 2022/12/16
CRDT- 2022/12/23 01:07
PHST- 2022/12/23 01:07 [entrez]
PHST- 2022/12/24 06:00 [pubmed]
PHST- 2022/12/27 06:00 [medline]
PHST- 2022/12/16 00:00 [pmc-release]
AID - 00005792-202212160-00089 [pii]
AID - 10.1097/MD.0000000000032342 [doi]
PST - ppublish
SO  - Medicine (Baltimore). 2022 Dec 16;101(50):e32342. doi: 
      10.1097/MD.0000000000032342.