PMID- 36551229
OWN - NLM
STAT- MEDLINE
DCOM- 20230118
LR  - 20230118
IS  - 2218-273X (Electronic)
IS  - 2218-273X (Linking)
VI  - 12
IP  - 12
DP  - 2022 Dec 1
TI  - IL-18BP Improves Early Graft Function and Survival in Lewis-Brown Norway Rat 
      Orthotopic Liver Transplantation Model.
LID - 10.3390/biom12121801 [doi]
LID - 1801
AB  - Interleukin-18 (IL-18) can effectively activate natural killer (NK) cells and 
      induce large concentrations of interferon-gamma (IFN-gamma). In healthy humans, IL-18 
      binding protein (IL-18BP) can inhibit the binding of IL-18 to IL-18R and 
      counteract the biological action of IL-18 due to its high concentration and high 
      affinity, thus preventing the production of IFN-gamma and inhibiting NK-cell 
      activation. Through previous studies and the phenomena observed by our group in 
      pig-non-human primates (NHPs) liver transplantation experiments, we proposed that 
      the imbalance in IL-18/IL-18BP expression upon transplantation encourages the 
      activation, proliferation, and cytotoxic effects of NK cells, ultimately causing 
      acute vascular rejection of the graft. In this research, we used Lewis-Brown 
      Norway rat orthotopic liver transplantation (OLTx) as a model of acute vascular 
      rejection. AAV8-Il18bp viral vectors as gene delivery vehicles were constructed 
      for gene therapy to overexpress IL-18BP and alleviate NK-cell rejection of the 
      graft after transplantation. The results showed that livers overexpressing 
      IL-18BP had reduced damage and could function longer after transplantation, 
      effectively improving the survival time of the recipients.
FAU - Meng, Qiang
AU  - Meng Q
AUID- ORCID: 0000-0003-2646-026X
AD  - Department of Hepatobiliary Surgery, Xi-Jing Hospital, Fourth Military Medical 
      University, Xi'an 710032, China.
FAU - Wu, Weikang
AU  - Wu W
AD  - Department of Hepatobiliary Surgery, Xi-Jing Hospital, Fourth Military Medical 
      University, Xi'an 710032, China.
FAU - Zhang, Wenjie
AU  - Zhang W
AD  - Department of Hepatobiliary Surgery, Xi-Jing Hospital, Fourth Military Medical 
      University, Xi'an 710032, China.
AD  - Chinese Education Ministry's Key Laboratory of Western Resources and Modern 
      Biotechnology, Key Laboratory of Biotechnology Shaanxi Province, College of Life 
      Sciences, Northwest University, Xi'an 710032, China.
FAU - Yuan, Juzheng
AU  - Yuan J
AD  - Department of Hepatobiliary Surgery, Xi-Jing Hospital, Fourth Military Medical 
      University, Xi'an 710032, China.
FAU - Yang, Long
AU  - Yang L
AD  - Department of Hepatobiliary Surgery, Xi-Jing Hospital, Fourth Military Medical 
      University, Xi'an 710032, China.
FAU - Zhang, Xuan
AU  - Zhang X
AD  - Department of Hepatobiliary Surgery, Xi-Jing Hospital, Fourth Military Medical 
      University, Xi'an 710032, China.
FAU - Tao, Kaishan
AU  - Tao K
AD  - Department of Hepatobiliary Surgery, Xi-Jing Hospital, Fourth Military Medical 
      University, Xi'an 710032, China.
LA  - eng
GR  - 81970566/National Natural Science Foundation of China/
GR  - 82170667/National Natural Science Foundation of China/
GR  - 81900571/National Natural Science Foundation of China/
GR  - AKJ19J001/Major Military Logistics Research Projects/
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20221201
PL  - Switzerland
TA  - Biomolecules
JT  - Biomolecules
JID - 101596414
RN  - 82115-62-6 (Interferon-gamma)
RN  - 0 (Interleukin-18)
RN  - 0 (interleukin-18 binding protein)
SB  - IM
MH  - Animals
MH  - Rats
MH  - *Graft Rejection/prevention & control
MH  - Interferon-gamma/genetics/metabolism
MH  - *Interleukin-18/genetics/metabolism
MH  - *Liver Transplantation/methods
MH  - Rats, Inbred Lew
MH  - *Graft Survival/genetics
MH  - *Genetic Therapy
MH  - *Blood Vessels/immunology
MH  - Genetic Vectors
PMC - PMC9775331
OTO - NOTNLM
OT  - IL-18 binding protein
OT  - acute vascular rejection
OT  - liver xenotransplantation
OT  - natural killer cell
OT  - orthotopic liver transplantation
COIS- The authors declare no conflict of interest.
EDAT- 2022/12/24 06:00
MHDA- 2022/12/27 06:00
PMCR- 2022/12/01
CRDT- 2022/12/23 01:09
PHST- 2022/11/01 00:00 [received]
PHST- 2022/11/28 00:00 [revised]
PHST- 2022/11/29 00:00 [accepted]
PHST- 2022/12/23 01:09 [entrez]
PHST- 2022/12/24 06:00 [pubmed]
PHST- 2022/12/27 06:00 [medline]
PHST- 2022/12/01 00:00 [pmc-release]
AID - biom12121801 [pii]
AID - biomolecules-12-01801 [pii]
AID - 10.3390/biom12121801 [doi]
PST - epublish
SO  - Biomolecules. 2022 Dec 1;12(12):1801. doi: 10.3390/biom12121801.