PMID- 36551614
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230308
IS  - 2072-6694 (Print)
IS  - 2072-6694 (Electronic)
IS  - 2072-6694 (Linking)
VI  - 14
IP  - 24
DP  - 2022 Dec 12
TI  - Incidence and Clinical Description of Lymphomas in Children and Adolescents with 
      Vertical Transmission of HIV in Rio de Janeiro, Brazil, in Pre- and Post-Combined 
      Antiretroviral Therapy Eras: A Multicentric Hospital-Based Survival Analysis 
      Study.
LID - 10.3390/cancers14246129 [doi]
LID - 6129
AB  - The incidence of cancer in children living with HIV (CLWH) is high and lymphomas 
      are the most common type of cancer in this population. The combined 
      antiretroviral therapy (cART) changed the natural history of HIV infection. To 
      determine the incidence and profile of these CLWH malignancies in Rio de Janeiro 
      (RJ), Brazil, we conducted a retrospective and observational study of vertically 
      infected CLWH, ranging from 0-20 incomplete years, from 1995 to 2018, at five 
      reference centers. The study period was divided into three eras in accordance 
      with the widespread use of cART in Brazil. 1306 patients were included. Of the 25 
      lymphomas found, 19 were AIDS-defining malignancies (ADM); 6 were 
      non-AIDS-defining malignancies (NADM). The incidence rate (IR) of lymphoma 
      developing was 1.70 per 1000 children-year (95% CI 1.09-2.50). ADM development IR 
      decreased from 2.09-1.75-0.19 per 1000 children-year (p < 0.001) through cART 
      eras. Cumulative Nelson-Aalen hazards of developing ADM over a 20-year period 
      were 3.73% in the Early-cART era, 3.07% in the Mid-cART era, and 0.32% in the 
      Late-cART era (p = 0.013). This study demonstrates the IR of lymphoma in CLWH in 
      RJ, Brazil, as well as the benefit of cART in reducing ADM and death occurrence 
      in the Post-cART era.
FAU - Duarte, Nathalia Lopez
AU  - Duarte NL
AUID- ORCID: 0000-0002-6433-2368
AD  - Faculty of Medicine (FM), Federal University of Rio de Janeiro (UFRJ), Rio de 
      Janeiro 21941-617, Brazil.
AD  - Internal Medicine Postgraduate Program, Faculty of Medicine (FM), Federal 
      University of Rio de Janeiro (UFRJ), Rio de Janeiro 21941-617, Brazil.
AD  - Transdisciplinary Center for Research in Child and Adolescent Health (NTISCA), 
      Institute of Pediatrics and Childcare Martagao Gesteira (IPPMG), Federal 
      University of Rio de Janeiro (UFRJ), Rio de Janeiro 21941-612, Brazil.
FAU - Bueno, Ana Paula Silva
AU  - Bueno APS
AD  - Transdisciplinary Center for Research in Child and Adolescent Health (NTISCA), 
      Institute of Pediatrics and Childcare Martagao Gesteira (IPPMG), Federal 
      University of Rio de Janeiro (UFRJ), Rio de Janeiro 21941-612, Brazil.
AD  - Pediatric Hematology Service, Institute of Pediatrics and Childcare Martagao 
      Gesteira (IPPMG), Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro 
      21941-612, Brazil.
FAU - Sanches, Barbara Sarni
AU  - Sanches BS
AD  - Faculty of Medicine (FM), Federal University of Rio de Janeiro (UFRJ), Rio de 
      Janeiro 21941-617, Brazil.
AD  - Transdisciplinary Center for Research in Child and Adolescent Health (NTISCA), 
      Institute of Pediatrics and Childcare Martagao Gesteira (IPPMG), Federal 
      University of Rio de Janeiro (UFRJ), Rio de Janeiro 21941-612, Brazil.
FAU - Ramos, Gabriella Alves
AU  - Ramos GA
AUID- ORCID: 0000-0001-5707-9803
AD  - Transdisciplinary Center for Research in Child and Adolescent Health (NTISCA), 
      Institute of Pediatrics and Childcare Martagao Gesteira (IPPMG), Federal 
      University of Rio de Janeiro (UFRJ), Rio de Janeiro 21941-612, Brazil.
AD  - Faculty of Medical Sciences (FCM), Pedro Ernesto University Hospital (HUPE), 
      State University of Rio de Janeiro (UERJ), Rio de Janeiro 20551-030, Brazil.
FAU - Santos, Julia Maria Bispo Dos
AU  - Santos JMBD
AD  - Faculty of Medicine (FM), Federal University of Rio de Janeiro (UFRJ), Rio de 
      Janeiro 21941-617, Brazil.
AD  - Transdisciplinary Center for Research in Child and Adolescent Health (NTISCA), 
      Institute of Pediatrics and Childcare Martagao Gesteira (IPPMG), Federal 
      University of Rio de Janeiro (UFRJ), Rio de Janeiro 21941-612, Brazil.
FAU - Silva, Henrique Floriano Hess E
AU  - Silva HFHE
AD  - Faculty of Medicine (FM), Federal University of Rio de Janeiro (UFRJ), Rio de 
      Janeiro 21941-617, Brazil.
AD  - Transdisciplinary Center for Research in Child and Adolescent Health (NTISCA), 
      Institute of Pediatrics and Childcare Martagao Gesteira (IPPMG), Federal 
      University of Rio de Janeiro (UFRJ), Rio de Janeiro 21941-612, Brazil.
FAU - de Oliveira Ponde, Janaina
AU  - de Oliveira Ponde J
AD  - Faculty of Medicine (FM), Federal University of Rio de Janeiro (UFRJ), Rio de 
      Janeiro 21941-617, Brazil.
AD  - Transdisciplinary Center for Research in Child and Adolescent Health (NTISCA), 
      Institute of Pediatrics and Childcare Martagao Gesteira (IPPMG), Federal 
      University of Rio de Janeiro (UFRJ), Rio de Janeiro 21941-612, Brazil.
FAU - de Sa, Jose Gilberto
AU  - de Sa JG
AUID- ORCID: 0000-0002-1038-3928
AD  - Department of Infectious and Parasitic Diseases, Hospital Municipal Jesus (HMJ), 
      Municipal Health Secretariat (SMS-RJ), Rio de Janeiro 20550-200, Brazil.
FAU - Rossi, Priscila Mazucanti
AU  - Rossi PM
AD  - Department of Infectious and Parasitic Diseases, Hospital Municipal Jesus (HMJ), 
      Municipal Health Secretariat (SMS-RJ), Rio de Janeiro 20550-200, Brazil.
FAU - Horn, Patricia Regina Cavalcanti Barbosa
AU  - Horn PRCB
AD  - Department of Hematology, Pedro Ernesto University Hospital (HUPE), State 
      University of Rio de Janeiro (UERJ), Rio de Janeiro 20551-030, Brazil.
FAU - das Neves Sztajnbok, Denise Cardoso
AU  - das Neves Sztajnbok DC
AD  - Pediatric Infectious Diseases Division, Department of Pediatrics, Pedro Ernesto 
      University Hospital (HUPE), State University of Rio de Janeiro (UERJ), Rio de 
      Janeiro 20551-030, Brazil.
FAU - de Paula Motta Rubini, Norma
AU  - de Paula Motta Rubini N
AD  - Department of Allergy and Immunology, School of Medicine and Surgery, Gaffree and 
      Guinle University Hospital (HUGG), Federal University of the State of Rio de 
      Janeiro (UNIRIO), Rio de Janeiro 20270-004, Brazil.
FAU - Milito, Cristiane Bedran
AU  - Milito CB
AD  - Faculty of Medicine (FM), Federal University of Rio de Janeiro (UFRJ), Rio de 
      Janeiro 21941-617, Brazil.
AD  - Department of Pathology, Faculty of Medicine (FM), Clementino Fraga Filho 
      University Hospital (HUCFF), Federal University of Rio de Janeiro (UFRJ), Rio de 
      Janeiro 21941-617, Brazil.
FAU - de Abreu, Thalita Fernandes
AU  - de Abreu TF
AUID- ORCID: 0000-0002-6412-1093
AD  - Faculty of Medicine (FM), Federal University of Rio de Janeiro (UFRJ), Rio de 
      Janeiro 21941-617, Brazil.
AD  - Infectious and Parasitic Diseases Service, Institute of Pediatrics and Childcare 
      Martagao Gesteira (IPPMG), Federal University of Rio de Janeiro (UFRJ), Rio de 
      Janeiro 21941-612, Brazil.
FAU - Land, Marcelo Gerardin Poirot
AU  - Land MGP
AUID- ORCID: 0000-0001-9792-3167
AD  - Faculty of Medicine (FM), Federal University of Rio de Janeiro (UFRJ), Rio de 
      Janeiro 21941-617, Brazil.
AD  - Internal Medicine Postgraduate Program, Faculty of Medicine (FM), Federal 
      University of Rio de Janeiro (UFRJ), Rio de Janeiro 21941-617, Brazil.
AD  - Transdisciplinary Center for Research in Child and Adolescent Health (NTISCA), 
      Institute of Pediatrics and Childcare Martagao Gesteira (IPPMG), Federal 
      University of Rio de Janeiro (UFRJ), Rio de Janeiro 21941-612, Brazil.
AD  - Pediatric Hematology Service, Institute of Pediatrics and Childcare Martagao 
      Gesteira (IPPMG), Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro 
      21941-612, Brazil.
LA  - eng
GR  - 88887.352126/2019-00/Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior/
PT  - Journal Article
DEP - 20221212
PL  - Switzerland
TA  - Cancers (Basel)
JT  - Cancers
JID - 101526829
PMC - PMC9776495
OTO - NOTNLM
OT  - Brazil
OT  - HIV
OT  - combined antiretroviral therapy (cART)
OT  - epidemiology
OT  - incidence
OT  - lymphoma
OT  - pediatric
OT  - vertical transmission (VT)
COIS- The authors declare no conflict of interest.
EDAT- 2022/12/24 06:00
MHDA- 2022/12/24 06:01
PMCR- 2022/12/12
CRDT- 2022/12/23 01:11
PHST- 2022/10/20 00:00 [received]
PHST- 2022/11/25 00:00 [revised]
PHST- 2022/12/06 00:00 [accepted]
PHST- 2022/12/23 01:11 [entrez]
PHST- 2022/12/24 06:00 [pubmed]
PHST- 2022/12/24 06:01 [medline]
PHST- 2022/12/12 00:00 [pmc-release]
AID - cancers14246129 [pii]
AID - cancers-14-06129 [pii]
AID - 10.3390/cancers14246129 [doi]
PST - epublish
SO  - Cancers (Basel). 2022 Dec 12;14(24):6129. doi: 10.3390/cancers14246129.