PMID- 36551901
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20221225
IS  - 2227-9059 (Print)
IS  - 2227-9059 (Electronic)
IS  - 2227-9059 (Linking)
VI  - 10
IP  - 12
DP  - 2022 Dec 6
TI  - Hyperbaric Oxygen Therapy and Tissue Regeneration: A Literature Survey.
LID - 10.3390/biomedicines10123145 [doi]
LID - 3145
AB  - By addressing the mechanisms involved in transcription, signaling, stress 
      reaction, apoptosis and cell-death, cellular structure and cell-to-cell contacts, 
      adhesion, migration as well as inflammation; HBO upregulates processes involved 
      in repair while mechanisms perpetuating tissue damage are downregulated. Many 
      experimental and clinical studies, respectively, cover wound healing, 
      regeneration of neural tissue, of bone and cartilage, muscle, and cardiac tissue 
      as well as intestinal barrier function. Following acute injury or in chronic 
      healing problems HBO modulates proteins or molecules involved in inflammation, 
      apoptosis, cell growth, neuro- and angiogenesis, scaffolding, perfusion, 
      vascularization, and stem-cell mobilization, initiating repair by a variety of 
      mechanisms, some of them based on the modulation of micro-RNAs. HBO affects the 
      oxidative stress response via nuclear factor erythroid 2-related factor 2 (Nrf2) 
      or c-Jun N-terminal peptide and downregulates inflammation by the modulation of 
      high-mobility group protein B1 (HMGB-1), toll-like receptor 4 and 2 (TLR-4, 
      TLR-2), nuclear factor kappa-B (NFkappaB), hypoxia-inducible factor (HIF-1alpha) and 
      nitric oxide (NO*). HBO enhances stem-cell homeostasis via Wnt glycoproteins and 
      mammalian target of rapamycin (mTOR) and improves cell repair, growth, and 
      differentiation via the two latter but also by modulation of extracellular-signal 
      regulated kinases (ERK) and the phosphatidylinositol-3-kinase (PI3K)/protein 
      kinase B (AKT) pathway. The HBO-induced downregulation of matrix 
      metalloproteinases-2 and 9 (MMP-2/-9), rho-associated protein kinase (ROCK) and 
      integrins improve healing by tissue remodeling. Interestingly, the action of HBO 
      on single effector proteins or molecules may involve both up- or downregulation, 
      respectively, depending on their initial level. This probably mirrors a generally 
      stabilizing potential of HBO that tends to restore the physiological balance 
      rather than enhancing or counteracting single mechanisms.
FAU - Lindenmann, J
AU  - Lindenmann J
AUID- ORCID: 0000-0003-1276-7666
AD  - Division of Thoracic and Hyperbaric Surgery, Medical University of Graz, A-8036 
      Graz, Austria.
FAU - Kamolz, L
AU  - Kamolz L
AUID- ORCID: 0000-0002-5975-876X
AD  - Division of Plastic, Aesthetic and Reconstructive Surgery, Medical University of 
      Graz, A-8036 Graz, Austria.
FAU - Graier, W
AU  - Graier W
AUID- ORCID: 0000-0003-1871-3298
AD  - Gottfried Schatz Research Center for Cell Signaling, Metabolism and Aging, 
      Molecular Biology and Biochemistry, A-8036 Graz, Austria.
FAU - Smolle, J
AU  - Smolle J
AUID- ORCID: 0000-0002-8005-4660
AD  - Institute of Informatics, Statistics and Documentation, Medical University of 
      Graz, A-8036 Graz, Austria.
FAU - Smolle-Juettner, F-M
AU  - Smolle-Juettner FM
AUID- ORCID: 0000-0002-0875-0821
AD  - Division of Thoracic and Hyperbaric Surgery, Medical University of Graz, A-8036 
      Graz, Austria.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20221206
PL  - Switzerland
TA  - Biomedicines
JT  - Biomedicines
JID - 101691304
PMC - PMC9775938
OTO - NOTNLM
OT  - hyperbaric oxygen
OT  - mechanism
OT  - tissue regeneration
COIS- The authors declare no conflict of interest.
EDAT- 2022/12/24 06:00
MHDA- 2022/12/24 06:01
PMCR- 2022/12/06
CRDT- 2022/12/23 01:12
PHST- 2022/11/03 00:00 [received]
PHST- 2022/11/30 00:00 [accepted]
PHST- 2022/12/23 01:12 [entrez]
PHST- 2022/12/24 06:00 [pubmed]
PHST- 2022/12/24 06:01 [medline]
PHST- 2022/12/06 00:00 [pmc-release]
AID - biomedicines10123145 [pii]
AID - biomedicines-10-03145 [pii]
AID - 10.3390/biomedicines10123145 [doi]
PST - epublish
SO  - Biomedicines. 2022 Dec 6;10(12):3145. doi: 10.3390/biomedicines10123145.