PMID- 36552176 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20221225 IS - 2076-3425 (Print) IS - 2076-3425 (Electronic) IS - 2076-3425 (Linking) VI - 12 IP - 12 DP - 2022 Dec 15 TI - Validation of the Longitudinal Interval Follow-Up Evaluation for the Long-Term Measurement of Mood Symptoms in Bipolar Disorder. LID - 10.3390/brainsci12121717 [doi] LID - 1717 AB - The long-term burden of symptoms is an important outcome in bipolar disorder (BD). A method which has minimal burden of assessment uses a retrospective interview, the Longitudinal Interval Follow-up Examination (LIFE), although this may be subject to problems with recall. This study examines the relationship between the retrospective LIFE scale and concurrently-rated mood rating scales in two clinical trials of 18 months of psychotherapy for patients with BD. The Montgomery-Asberg Depression Rating Scale (MADRS) and Young Mania Rating Scale (YMRS) were administered every eight to nine weeks and the LIFE was carried out every 6 months. Correlations between scores on mood rating scales and at equivalent times on the LIFE were examined, as well as of potential clinical moderators. There were significant correlations between LIFE depression ratings and concurrent MADRS score (r = 0.57) and between LIFE mania ratings and YMRS score (r = 0.40). In determining "mild depression" on the MADRS, a receiver operating characteristics (ROC) analysis showed an AUC of 0.78 for LIFE scores. Correlations, particularly for depression scores, were high even when the LIFE rating was several months before the interview, suggesting that the LIFE has validity in examining the burden of mood symptoms over time, with relatively little burden of assessment. Future research should examine the relationship between symptom burden and quality of life measured in this way. FAU - Porter, Richard J AU - Porter RJ AD - Department of Psychological Medicine, University of Otago, Christchurch 4345, New Zealand. AD - Specialist Mental Health Services, Te Whatu Ora, Christchurch 8025, New Zealand. FAU - Moot, Will AU - Moot W AD - Department of Psychological Medicine, University of Otago, Christchurch 4345, New Zealand. FAU - Inder, Maree L AU - Inder ML AD - Department of Psychological Medicine, University of Otago, Christchurch 4345, New Zealand. FAU - Crowe, Marie T AU - Crowe MT AD - Department of Psychological Medicine, University of Otago, Christchurch 4345, New Zealand. FAU - Douglas, Katie M AU - Douglas KM AD - Department of Psychological Medicine, University of Otago, Christchurch 4345, New Zealand. FAU - Carter, Janet D AU - Carter JD AD - School of Psychology, Speech and Hearing, University of Canterbury, Christchurch 8140, New Zealand. FAU - Frampton, Christopher AU - Frampton C AD - Department of Psychological Medicine, University of Otago, Christchurch 4345, New Zealand. LA - eng GR - 11/256/Health Research Council of New Zealand/ PT - Journal Article DEP - 20221215 PL - Switzerland TA - Brain Sci JT - Brain sciences JID - 101598646 PMC - PMC9776034 OTO - NOTNLM OT - bipolar disorder OT - longitudinal assessment OT - mood assessment OT - mood rating scales OT - psychotherapy COIS- K.M.D. and R.J.P. use software provided free-of-charge by Scientific Brain Training Pro for Cognitive Remediation trials. R.J.P. has received support for travel to educational meetings from Servier and Lundbeck. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, or in the decision to publish the results. EDAT- 2022/12/24 06:00 MHDA- 2022/12/24 06:01 PMCR- 2022/12/15 CRDT- 2022/12/23 01:14 PHST- 2022/11/08 00:00 [received] PHST- 2022/11/30 00:00 [revised] PHST- 2022/12/01 00:00 [accepted] PHST- 2022/12/23 01:14 [entrez] PHST- 2022/12/24 06:00 [pubmed] PHST- 2022/12/24 06:01 [medline] PHST- 2022/12/15 00:00 [pmc-release] AID - brainsci12121717 [pii] AID - brainsci-12-01717 [pii] AID - 10.3390/brainsci12121717 [doi] PST - epublish SO - Brain Sci. 2022 Dec 15;12(12):1717. doi: 10.3390/brainsci12121717.