PMID- 36552462
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20221225
IS  - 2076-2615 (Print)
IS  - 2076-2615 (Electronic)
IS  - 2076-2615 (Linking)
VI  - 12
IP  - 24
DP  - 2022 Dec 15
TI  - Signaling Lymphocytic Activation Molecule Family Member 1 Inhibits Porcine 
      Reproductive and Respiratory Syndrome Virus Replication.
LID - 10.3390/ani12243542 [doi]
LID - 3542
AB  - The porcine reproductive and respiratory syndrome virus (PRRSV) causes a highly 
      contagious disease in domestic swine. Signaling lymphocytic activation molecule 
      family member 1 (SLAMF1) is a costimulatory factor that is involved in innate 
      immunity, inflammation, and infection. Here, we demonstrate that overexpression 
      of the SLAMF1 gene inhibited PRRSV replication significantly and reduced the 
      levels of key signaling pathways, including MyD88, RIG-I, TLR2, TRIF, and 
      inflammatory factors IL-6, IL-1beta, IL-8, TNF-beta, TNF-alpha, and IFN-alpha in vitro. 
      However, the knockdown of the SLAMF1 gene could enhance replication of the PRRSV 
      and the levels of key signaling pathways and inflammatory factors. Overall, our 
      results identify a new, to our knowledge, antagonist of the PRRSV, as well as a 
      novel antagonistic mechanism evolved by inhibiting innate immunity and 
      inflammation, providing a new reference and direction for PRRSV disease 
      resistance breeding.
FAU - Song, Haofei
AU  - Song H
AD  - College of Animal Science, Yangtze University, Jingzhou 434025, China.
AD  - Key Laboratory of Prevention and Control Agents for Animal Bacteriosis (Ministry 
      of Agriculture and Rural Affairs), Hubei Provincial Key Laboratory of Animal 
      Pathogenic Microbiology, Institute of Animal Husbandry and Veterinary, Hubei 
      Academy of Agricultural Sciences, Wuhan 430064, China.
FAU - Quan, Jima
AU  - Quan J
AD  - College of Animal Science, Yangtze University, Jingzhou 434025, China.
AD  - Key Laboratory of Prevention and Control Agents for Animal Bacteriosis (Ministry 
      of Agriculture and Rural Affairs), Hubei Provincial Key Laboratory of Animal 
      Pathogenic Microbiology, Institute of Animal Husbandry and Veterinary, Hubei 
      Academy of Agricultural Sciences, Wuhan 430064, China.
FAU - Li, Chang
AU  - Li C
AUID- ORCID: 0000-0003-3133-2369
AD  - Key Laboratory of Prevention and Control Agents for Animal Bacteriosis (Ministry 
      of Agriculture and Rural Affairs), Hubei Provincial Key Laboratory of Animal 
      Pathogenic Microbiology, Institute of Animal Husbandry and Veterinary, Hubei 
      Academy of Agricultural Sciences, Wuhan 430064, China.
FAU - Liang, Wan
AU  - Liang W
AUID- ORCID: 0000-0002-1612-3422
AD  - Key Laboratory of Prevention and Control Agents for Animal Bacteriosis (Ministry 
      of Agriculture and Rural Affairs), Hubei Provincial Key Laboratory of Animal 
      Pathogenic Microbiology, Institute of Animal Husbandry and Veterinary, Hubei 
      Academy of Agricultural Sciences, Wuhan 430064, China.
FAU - Zhang, Lan
AU  - Zhang L
AD  - College of Animal Science, Yangtze University, Jingzhou 434025, China.
AD  - Key Laboratory of Prevention and Control Agents for Animal Bacteriosis (Ministry 
      of Agriculture and Rural Affairs), Hubei Provincial Key Laboratory of Animal 
      Pathogenic Microbiology, Institute of Animal Husbandry and Veterinary, Hubei 
      Academy of Agricultural Sciences, Wuhan 430064, China.
FAU - Wang, Shuangshuang
AU  - Wang S
AD  - Key Laboratory of Prevention and Control Agents for Animal Bacteriosis (Ministry 
      of Agriculture and Rural Affairs), Hubei Provincial Key Laboratory of Animal 
      Pathogenic Microbiology, Institute of Animal Husbandry and Veterinary, Hubei 
      Academy of Agricultural Sciences, Wuhan 430064, China.
FAU - Lu, Hongyu
AU  - Lu H
AUID- ORCID: 0000-0002-0313-4114
AD  - Key Laboratory of Prevention and Control Agents for Animal Bacteriosis (Ministry 
      of Agriculture and Rural Affairs), Hubei Provincial Key Laboratory of Animal 
      Pathogenic Microbiology, Institute of Animal Husbandry and Veterinary, Hubei 
      Academy of Agricultural Sciences, Wuhan 430064, China.
FAU - Yang, Keli
AU  - Yang K
AD  - Key Laboratory of Prevention and Control Agents for Animal Bacteriosis (Ministry 
      of Agriculture and Rural Affairs), Hubei Provincial Key Laboratory of Animal 
      Pathogenic Microbiology, Institute of Animal Husbandry and Veterinary, Hubei 
      Academy of Agricultural Sciences, Wuhan 430064, China.
FAU - Zhou, Danna
AU  - Zhou D
AUID- ORCID: 0000-0001-9616-2976
AD  - Key Laboratory of Prevention and Control Agents for Animal Bacteriosis (Ministry 
      of Agriculture and Rural Affairs), Hubei Provincial Key Laboratory of Animal 
      Pathogenic Microbiology, Institute of Animal Husbandry and Veterinary, Hubei 
      Academy of Agricultural Sciences, Wuhan 430064, China.
FAU - Li, Peng
AU  - Li P
AD  - College of Animal Science, Yangtze University, Jingzhou 434025, China.
FAU - Tian, Yongxiang
AU  - Tian Y
AD  - Key Laboratory of Prevention and Control Agents for Animal Bacteriosis (Ministry 
      of Agriculture and Rural Affairs), Hubei Provincial Key Laboratory of Animal 
      Pathogenic Microbiology, Institute of Animal Husbandry and Veterinary, Hubei 
      Academy of Agricultural Sciences, Wuhan 430064, China.
LA  - eng
GR  - 2022NKYJJ09/Wan Liang/
GR  - 2021ABA005/Danna Zhou/
GR  - 2019-620-000-001-017/Yongxiang Tian/
PT  - Journal Article
DEP - 20221215
PL  - Switzerland
TA  - Animals (Basel)
JT  - Animals : an open access journal from MDPI
JID - 101635614
PMC - PMC9774311
OTO - NOTNLM
OT  - PRRSV
OT  - SLAMF1
OT  - inflammatory cytokines
OT  - innate immunity
OT  - replication
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/12/24 06:00
MHDA- 2022/12/24 06:01
PMCR- 2022/12/15
CRDT- 2022/12/23 01:15
PHST- 2022/11/01 00:00 [received]
PHST- 2022/12/09 00:00 [revised]
PHST- 2022/12/11 00:00 [accepted]
PHST- 2022/12/23 01:15 [entrez]
PHST- 2022/12/24 06:00 [pubmed]
PHST- 2022/12/24 06:01 [medline]
PHST- 2022/12/15 00:00 [pmc-release]
AID - ani12243542 [pii]
AID - animals-12-03542 [pii]
AID - 10.3390/ani12243542 [doi]
PST - epublish
SO  - Animals (Basel). 2022 Dec 15;12(24):3542. doi: 10.3390/ani12243542.