PMID- 36553161
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20221225
IS  - 2075-4418 (Print)
IS  - 2075-4418 (Electronic)
IS  - 2075-4418 (Linking)
VI  - 12
IP  - 12
DP  - 2022 Dec 14
TI  - A Modified Run-Off Resistance Score from Cross-Sectional Imaging Discriminates 
      Chronic Critical Limb Ischemia from Intermittent Claudication in Peripheral 
      Arterial Disease.
LID - 10.3390/diagnostics12123155 [doi]
LID - 3155
AB  - Atherosclerotic peripheral arterial disease (PAD) leads to intermittent 
      claudication (IC) and may progress into chronic limb-threatening ischemia (CLTI). 
      Scoring systems to determine the atherosclerotic burden of a diseased extremity 
      have been developed. This study aimed to evaluate a modification of the run-off 
      resistance (mROR) score for its usability in cross-sectional imaging. The mROR 
      was determined from preoperative imaging of patients undergoing revascularization 
      for PAD. A total of 20 patients with IC and 20 patients with CLTI were 
      consecutively included. A subgroup analysis for diabetic patients was conducted. 
      The mROR was evaluated for its correlation with disease severity and clinical 
      covariates. Patients with CLTI were older; cardiovascular risk factors, diabetes, 
      and ASA 4 were more frequent. The mROR scores were higher in CLTI than in IC. In 
      diabetic patients, no difference was detected between CLTI and IC. In CLTI, 
      non-diabetic patients had a higher mROR. The mROR score is positively correlated 
      with the severity of PAD and can discriminate CLTI from IC. In diabetic patients 
      with CLTI, the mROR is lower than in non-diabetic patients. The mROR score can be 
      determined from cross-sectional imaging angiographies. It may be useful for 
      clinicians helping with vascular case planning, as well as for scientific 
      purposes.
FAU - Frese, Jan Paul
AU  - Frese JP
AUID- ORCID: 0000-0002-2690-0731
AD  - Department of Vascular Surgery, Charite-Universitatsmedizin Berlin, 
      Hindenburgdamm 30, 12203 Berlin, Germany.
FAU - Schawe, Larissa
AU  - Schawe L
AD  - Department of Vascular Surgery, Charite-Universitatsmedizin Berlin, 
      Hindenburgdamm 30, 12203 Berlin, Germany.
FAU - Carstens, Jan
AU  - Carstens J
AD  - Department of Vascular Surgery, Charite-Universitatsmedizin Berlin, 
      Hindenburgdamm 30, 12203 Berlin, Germany.
FAU - Milbergs, Karlis
AU  - Milbergs K
AD  - Department of Vascular Surgery, Charite-Universitatsmedizin Berlin, 
      Hindenburgdamm 30, 12203 Berlin, Germany.
FAU - Speichinger, Fiona
AU  - Speichinger F
AD  - Department of Vascular Surgery, Charite-Universitatsmedizin Berlin, 
      Hindenburgdamm 30, 12203 Berlin, Germany.
FAU - Gratl, Alexandra
AU  - Gratl A
AUID- ORCID: 0000-0002-0533-3387
AD  - Department of Vascular Surgery, Medical University of Innsbruck, Anichstrasse 35, 
      6020 Innsbruck, Austria.
FAU - Greiner, Andreas
AU  - Greiner A
AD  - Department of Vascular Surgery, Charite-Universitatsmedizin Berlin, 
      Hindenburgdamm 30, 12203 Berlin, Germany.
FAU - Raude, Ben
AU  - Raude B
AD  - Department of Vascular Surgery, Charite-Universitatsmedizin Berlin, 
      Hindenburgdamm 30, 12203 Berlin, Germany.
LA  - eng
PT  - Journal Article
DEP - 20221214
PL  - Switzerland
TA  - Diagnostics (Basel)
JT  - Diagnostics (Basel, Switzerland)
JID - 101658402
PMC - PMC9777427
OTO - NOTNLM
OT  - angiography
OT  - atherosclerosis
OT  - chronic critical limb ischemia
OT  - diabetes
OT  - intermittent claudication
OT  - peripheral arterial disease
OT  - run-off resistance
COIS- The authors declare no conflict of interest.
EDAT- 2022/12/24 06:00
MHDA- 2022/12/24 06:01
PMCR- 2022/12/14
CRDT- 2022/12/23 01:19
PHST- 2022/10/27 00:00 [received]
PHST- 2022/12/03 00:00 [revised]
PHST- 2022/12/07 00:00 [accepted]
PHST- 2022/12/23 01:19 [entrez]
PHST- 2022/12/24 06:00 [pubmed]
PHST- 2022/12/24 06:01 [medline]
PHST- 2022/12/14 00:00 [pmc-release]
AID - diagnostics12123155 [pii]
AID - diagnostics-12-03155 [pii]
AID - 10.3390/diagnostics12123155 [doi]
PST - epublish
SO  - Diagnostics (Basel). 2022 Dec 14;12(12):3155. doi: 10.3390/diagnostics12123155.