PMID- 36554439
OWN - NLM
STAT- MEDLINE
DCOM- 20230103
LR  - 20230123
IS  - 1660-4601 (Electronic)
IS  - 1661-7827 (Print)
IS  - 1660-4601 (Linking)
VI  - 19
IP  - 24
DP  - 2022 Dec 9
TI  - Serum Levels of CXCR4, SDF-1, MCP-1, NF-kappaB and ERK1/2 in Patients with Skeletal 
      Fluorosis.
LID - 10.3390/ijerph192416555 [doi]
LID - 16555
AB  - C-X-C motif chemokine receptor 4 (CXCR4), stromal cell-derived factor-1 (SDF-1), 
      monocyte chemoattractant protein-1 (MCP-1), extracellular signal-regulated kinase 
      1/2 (ERK1/2) and nuclear factor-kappaB (NF-kappaB) affect bone cells and play an 
      important role in bone and joint diseases, but the data on CXCR4, SDF-1, MCP-1, 
      ERK1/2 and NF-kappaB in the serum of skeletal fluorosis (SF) patients are 
      inconclusive. Thus, according to the "Diagnostic Criteria for Endemic Skeletal 
      Fluorosis" (WS 192-2008), we enrolled patients with SF (n = 60) as the SF group 
      and those without SF as the controls (n = 60). Serum levels of CXCR4, SDF-1, 
      MCP-1, ERK1/2 and NF-kappaB were detected by enzyme-linked immunosorbent assays 
      (ELISAs). Serum SDF-1, CXCR4, MCP-1 and NF-kappaB levels were significantly higher in 
      the SF group than in the control group. Within the serum of SF patients, CXCR4 
      and SDF-1 levels were positively correlated with NF-kappaB levels. There was no 
      correlation between MCP-1 levels and those of ERK1/2 or NF-kappaB. SDF-1 and CXCR4 
      may activate the NF-kappaB pathway, and MCP-1 affects the occurrence and development 
      of SF by regulating osteocytes through other pathways. The SDF-1/CXCR4 axis and 
      MCP-1 signalling pathway provide a new theoretical basis for the occurrence and 
      development of SF.
FAU - Zhao, Yaqian
AU  - Zhao Y
AUID- ORCID: 0000-0002-0474-5419
AD  - Department of Public Health, Medical College, Qinghai University, Xi'ning 810016, 
      China.
AD  - Department of Endemic Disease Prevention and Control, Qinghai Institute for 
      Endemic Disease Prevention and Control, Xi'ning 811602, China.
FAU - Pu, Guanglan
AU  - Pu G
AD  - Department of Endemic Disease Prevention and Control, Qinghai Institute for 
      Endemic Disease Prevention and Control, Xi'ning 811602, China.
FAU - Li, Yanan
AU  - Li Y
AD  - Department of Endemic Disease Prevention and Control, Qinghai Institute for 
      Endemic Disease Prevention and Control, Xi'ning 811602, China.
FAU - Jiang, Hong
AU  - Jiang H
AD  - Department of Endemic Disease Prevention and Control, Qinghai Institute for 
      Endemic Disease Prevention and Control, Xi'ning 811602, China.
FAU - Zhang, Qiang
AU  - Zhang Q
AD  - Department of Public Health, Medical College, Qinghai University, Xi'ning 810016, 
      China.
AD  - Department of Endemic Disease Prevention and Control, Qinghai Institute for 
      Endemic Disease Prevention and Control, Xi'ning 811602, China.
FAU - Chen, Ping
AU  - Chen P
AD  - Department of Endemic Disease Prevention and Control, Qinghai Institute for 
      Endemic Disease Prevention and Control, Xi'ning 811602, China.
FAU - Lu, Qing
AU  - Lu Q
AD  - Department of Endemic Disease Prevention and Control, Qinghai Institute for 
      Endemic Disease Prevention and Control, Xi'ning 811602, China.
FAU - Wang, Mingjun
AU  - Wang M
AD  - Department of Endemic Disease Prevention and Control, Qinghai Institute for 
      Endemic Disease Prevention and Control, Xi'ning 811602, China.
FAU - Yang, Rui
AU  - Yang R
AD  - Department of Public Health, Medical College, Qinghai University, Xi'ning 810016, 
      China.
AD  - Department of Endemic Disease Prevention and Control, Qinghai Institute for 
      Endemic Disease Prevention and Control, Xi'ning 811602, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20221209
PL  - Switzerland
TA  - Int J Environ Res Public Health
JT  - International journal of environmental research and public health
JID - 101238455
RN  - 0 (Chemokine CCL2)
RN  - 0 (CXCR4 protein, human)
RN  - EC 2.7.11.24 (Mitogen-Activated Protein Kinase 3)
RN  - 0 (NF-kappa B)
RN  - 0 (Receptors, CXCR4)
SB  - IM
MH  - Humans
MH  - Chemokine CCL2/blood
MH  - *MAP Kinase Signaling System
MH  - Mitogen-Activated Protein Kinase 3/blood
MH  - *NF-kappa B/blood
MH  - Receptors, CXCR4/blood
MH  - Signal Transduction
MH  - *Bone Diseases/blood/diagnosis
PMC - PMC9778822
OTO - NOTNLM
OT  - chemokines
OT  - extracellular signal-regulated kinase 1/2
OT  - nuclear factor-kappaB
OT  - skeletal fluorosis
COIS- The authors declare no conflict of interest.
EDAT- 2022/12/24 06:00
MHDA- 2022/12/27 06:00
PMCR- 2022/12/09
CRDT- 2022/12/23 01:27
PHST- 2022/10/11 00:00 [received]
PHST- 2022/11/12 00:00 [revised]
PHST- 2022/11/30 00:00 [accepted]
PHST- 2022/12/23 01:27 [entrez]
PHST- 2022/12/24 06:00 [pubmed]
PHST- 2022/12/27 06:00 [medline]
PHST- 2022/12/09 00:00 [pmc-release]
AID - ijerph192416555 [pii]
AID - ijerph-19-16555 [pii]
AID - 10.3390/ijerph192416555 [doi]
PST - epublish
SO  - Int J Environ Res Public Health. 2022 Dec 9;19(24):16555. doi: 
      10.3390/ijerph192416555.