PMID- 36555135
OWN - NLM
STAT- MEDLINE
DCOM- 20221226
LR  - 20221226
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 23
IP  - 24
DP  - 2022 Dec 7
TI  - Elusive Trans-Acting Factors Which Operate with Type I (Poliovirus-like) IRES 
      Elements.
LID - 10.3390/ijms232415497 [doi]
LID - 15497
AB  - The phenomenon of internal initiation of translation was discovered in 1988 on 
      poliovirus mRNA. The prototypic cis-acting element in the 5' untranslated region 
      (5'UTR) of poliovirus mRNA, which is able to direct initiation at an internal 
      start codon without the involvement of a cap structure, has been called an IRES 
      (Internal Ribosome Entry Site or Segment). Despite its early discovery, 
      poliovirus and other related IRES elements of type I are poorly characterized, 
      and it is not yet clear which host proteins (a.k.a. IRES trans-acting factors, 
      ITAFs) are required for their full activity in vivo. Here we discuss recent and 
      old results devoted to type I IRESes and provide evidence that Poly(rC) binding 
      protein 2 (PCBP2), Glycyl-tRNA synthetase (GARS), and Cold Shock Domain 
      Containing E1 (CSDE1, also known as UNR) are major regulators of type I IRES 
      activity.
FAU - Andreev, Dmitry E
AU  - Andreev DE
AD  - Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, 117997 Moscow, Russia.
AD  - Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State 
      University, 119234 Moscow, Russia.
FAU - Niepmann, Michael
AU  - Niepmann M
AUID- ORCID: 0000-0002-0846-8658
AD  - Institute of Biochemistry, Medical Faculty, Justus-Liebig-University, 35392 
      Giessen, Germany.
FAU - Shatsky, Ivan N
AU  - Shatsky IN
AD  - Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State 
      University, 119234 Moscow, Russia.
LA  - eng
GR  - 19-14-00152/Russian Science Foundation/
GR  - 197785619-SFB 1021/Deutsche Forschungsgemeinschaft/
GR  - RTG 2355/Research Training Group/
PT  - Journal Article
PT  - Review
DEP - 20221207
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
RN  - 0 (Internal Ribosome Entry Sites)
RN  - 0 (Trans-Activators)
RN  - 0 (Codon, Initiator)
RN  - 0 (RNA, Messenger)
RN  - 0 (5' Untranslated Regions)
RN  - 0 (RNA, Viral)
SB  - IM
MH  - *Poliovirus/genetics/metabolism
MH  - Internal Ribosome Entry Sites/genetics
MH  - Trans-Activators/metabolism
MH  - Regulatory Sequences, Nucleic Acid
MH  - Codon, Initiator/metabolism
MH  - RNA, Messenger/metabolism
MH  - Protein Biosynthesis
MH  - 5' Untranslated Regions
MH  - RNA, Viral/metabolism
PMC - PMC9778869
OTO - NOTNLM
OT  - CSDE1
OT  - GARS
OT  - IRES
OT  - ITAF
OT  - PCBP2
OT  - STRAP
OT  - UNR
OT  - poliovirus
OT  - translation initiation
COIS- The authors declare no conflict of interest.
EDAT- 2022/12/24 06:00
MHDA- 2022/12/27 06:00
PMCR- 2022/12/07
CRDT- 2022/12/23 01:32
PHST- 2022/10/26 00:00 [received]
PHST- 2022/12/02 00:00 [revised]
PHST- 2022/12/05 00:00 [accepted]
PHST- 2022/12/23 01:32 [entrez]
PHST- 2022/12/24 06:00 [pubmed]
PHST- 2022/12/27 06:00 [medline]
PHST- 2022/12/07 00:00 [pmc-release]
AID - ijms232415497 [pii]
AID - ijms-23-15497 [pii]
AID - 10.3390/ijms232415497 [doi]
PST - epublish
SO  - Int J Mol Sci. 2022 Dec 7;23(24):15497. doi: 10.3390/ijms232415497.