PMID- 36555783 OWN - NLM STAT- MEDLINE DCOM- 20221226 LR - 20230405 IS - 1422-0067 (Electronic) IS - 1422-0067 (Linking) VI - 23 IP - 24 DP - 2022 Dec 18 TI - mTOR Signaling Network in Cell Biology and Human Disease. LID - 10.3390/ijms232416142 [doi] LID - 16142 AB - The mechanistic target of rapamycin (mTOR) is a serine/threonine protein kinase that regulates multiple processes, including gene transcription, protein synthesis, ribosome biogenesis, autophagy, cell metabolism, and cell growth [...]. FAU - Yu, Jane J AU - Yu JJ AD - Department of Internal Medicine, College of Medicine, University of Cincinnati, Cincinnati, OH 45267, USA. FAU - Goncharova, Elena A AU - Goncharova EA AUID- ORCID: 0000-0001-7118-6752 AD - Division of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Lung Center, School of Medicine, University of California Davis, Davis, CA 95616, USA. LA - eng GR - R01 HL113178/HL/NHLBI NIH HHS/United States GR - R01 HL130261/HL/NHLBI NIH HHS/United States GR - R01HL113178/National Institute of Health/ PT - Editorial DEP - 20221218 PL - Switzerland TA - Int J Mol Sci JT - International journal of molecular sciences JID - 101092791 RN - EC 2.7.11.1 (Mechanistic Target of Rapamycin Complex 1) RN - EC 2.7.11.1 (TOR Serine-Threonine Kinases) RN - EC 2.7.1.1 (MTOR protein, human) SB - IM MH - Humans MH - Mechanistic Target of Rapamycin Complex 1/metabolism MH - *TOR Serine-Threonine Kinases/metabolism MH - *Signal Transduction/genetics MH - Protein Biosynthesis MH - Autophagy PMC - PMC9787689 COIS- The authors declare no conflict of interest. EDAT- 2022/12/24 06:00 MHDA- 2022/12/27 06:00 PMCR- 2022/12/18 CRDT- 2022/12/23 01:36 PHST- 2022/12/08 00:00 [received] PHST- 2022/12/15 00:00 [revised] PHST- 2022/12/16 00:00 [accepted] PHST- 2022/12/23 01:36 [entrez] PHST- 2022/12/24 06:00 [pubmed] PHST- 2022/12/27 06:00 [medline] PHST- 2022/12/18 00:00 [pmc-release] AID - ijms232416142 [pii] AID - ijms-23-16142 [pii] AID - 10.3390/ijms232416142 [doi] PST - epublish SO - Int J Mol Sci. 2022 Dec 18;23(24):16142. doi: 10.3390/ijms232416142.