PMID- 36556029 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20221227 IS - 2077-0383 (Print) IS - 2077-0383 (Electronic) IS - 2077-0383 (Linking) VI - 11 IP - 24 DP - 2022 Dec 14 TI - Endoscopic Internalization by Cutting the Endoscopic Transpapillary Nasogallbladder Drainage Tube in Management of Acute Cholecystitis: A Retrospective Multicenter Cohort Study. LID - 10.3390/jcm11247415 [doi] LID - 7415 AB - BACKGROUND: Both endoscopic nasogallbladder drainage (ENGBD) and endoscopic gallbladder stenting (EGBS) are effective management for acute cholecystitis, although ENGBD can cause discomfort due to its nature of external drainage. Converting ENGBD to EGBS after improvement of cholecystitis might be one treatment strategy. The drainage tube of ENGBD could be endoscopically cut inside the stomach to convert to internal drainage without additional endoscopic retrograde cholangiography (ERCP). AIMS: To evaluate the feasibility, efficacy and safety of endoscopic internalization by cutting an ENGBD tube for acute cholecystitis. METHODS: Twenty-one patients who underwent endoscopic internalization by cutting the ENGBD tube were enrolled in this study. We initially placed an ENGBD tube for gallbladder lavage and continuous drainage. After improvement of cholecystitis, the tube was cut in the stomach by esophagogastroduodenoscopy (EGD) and placed as EGBS until surgery. RESULTS: The technical success rate of this procedure was 90.5% (19/21), and the clinical success rate was 100% (19/19). The median procedural time was 5 min (range: 2-14 min). Procedural-related adverse events (AEs) were observed in two patients where the tip of the ENGBD tube migrated into the common bile duct from the gallbladder during the procedure in both. During the waiting period for elective surgery, no AEs were identified, except for stent migration without symptoms in one patient (4.7%). CONCLUSION: Endoscopic internalization by cutting the ENGBD tube after improvement of cholecystitis could be an effective and safe treatment option for preventing recurrent cholecystitis in the waiting period until cholecystectomy. FAU - Maruta, Akinori AU - Maruta A AUID- ORCID: 0000-0002-2166-715X AD - Department of Gastroenterology, Gifu Prefectural General Medical Center, Gifu 500-8717, Japan. FAU - Iwashita, Takuji AU - Iwashita T AUID- ORCID: 0000-0003-4978-1787 AD - First Department of Internal Medicine, Gifu University Hospital, Gifu 501-1194, Japan. FAU - Yoshida, Kensaku AU - Yoshida K AUID- ORCID: 0000-0001-8936-1248 AD - Department of Gastroenterology, Gifu Prefectural General Medical Center, Gifu 500-8717, Japan. FAU - Iwata, Keisuke AU - Iwata K AD - Department of Gastroenterology, Gifu Municipal Hospital, Gifu 500-8513, Japan. FAU - Shimizu, Shogo AU - Shimizu S AD - Department of Gastroenterology, Gifu Prefectural General Medical Center, Gifu 500-8717, Japan. FAU - Shimizu, Masahito AU - Shimizu M AUID- ORCID: 0000-0002-1151-2058 AD - First Department of Internal Medicine, Gifu University Hospital, Gifu 501-1194, Japan. LA - eng PT - Journal Article DEP - 20221214 PL - Switzerland TA - J Clin Med JT - Journal of clinical medicine JID - 101606588 PMC - PMC9787409 OTO - NOTNLM OT - endoscopic retrograde cholangiopancreatography OT - endoscopic ultrasound OT - gallbladder drainage OT - internalization OT - palliative COIS- The authors declare no conflict of interest. EDAT- 2022/12/24 06:00 MHDA- 2022/12/24 06:01 PMCR- 2022/12/14 CRDT- 2022/12/23 01:38 PHST- 2022/11/17 00:00 [received] PHST- 2022/12/11 00:00 [accepted] PHST- 2022/12/23 01:38 [entrez] PHST- 2022/12/24 06:00 [pubmed] PHST- 2022/12/24 06:01 [medline] PHST- 2022/12/14 00:00 [pmc-release] AID - jcm11247415 [pii] AID - jcm-11-07415 [pii] AID - 10.3390/jcm11247415 [doi] PST - epublish SO - J Clin Med. 2022 Dec 14;11(24):7415. doi: 10.3390/jcm11247415.