PMID- 36558344
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20221226
IS  - 2079-4991 (Print)
IS  - 2079-4991 (Electronic)
IS  - 2079-4991 (Linking)
VI  - 12
IP  - 24
DP  - 2022 Dec 19
TI  - Nanoparticles in Drug Delivery: From History to Therapeutic Applications.
LID - 10.3390/nano12244494 [doi]
LID - 4494
AB  - Current research into the role of engineered nanoparticles in drug delivery 
      systems (DDSs) for medical purposes has developed numerous fascinating 
      nanocarriers. This paper reviews the various conventionally used and current used 
      carriage system to deliver drugs. Due to numerous drawbacks of conventional DDSs, 
      nanocarriers have gained immense interest. Nanocarriers like polymeric 
      nanoparticles, mesoporous nanoparticles, nanomaterials, carbon nanotubes, 
      dendrimers, liposomes, metallic nanoparticles, nanomedicine, and engineered 
      nanomaterials are used as carriage systems for targeted delivery at specific 
      sites of affected areas in the body. Nanomedicine has rapidly grown to treat 
      certain diseases like brain cancer, lung cancer, breast cancer, cardiovascular 
      diseases, and many others. These nanomedicines can improve drug bioavailability 
      and drug absorption time, reduce release time, eliminate drug aggregation, and 
      enhance drug solubility in the blood. Nanomedicine has introduced a new era for 
      drug carriage by refining the therapeutic directories of the energetic 
      pharmaceutical elements engineered within nanoparticles. In this context, the 
      vital information on engineered nanoparticles was reviewed and conferred towards 
      the role in drug carriage systems to treat many ailments. All these nanocarriers 
      were tested in vitro and in vivo. In the coming years, nanomedicines can improve 
      human health more effectively by adding more advanced techniques into the drug 
      delivery system.
FAU - Afzal, Obaid
AU  - Afzal O
AUID- ORCID: 0000-0002-4188-5592
AD  - Department of Pharmaceutical Chemistry, College of Pharmacy, Prince Sattam Bin 
      Abdulaziz University, Al Kharj 11942, Saudi Arabia.
FAU - Altamimi, Abdulmalik S A
AU  - Altamimi ASA
AD  - Department of Pharmaceutical Chemistry, College of Pharmacy, Prince Sattam Bin 
      Abdulaziz University, Al Kharj 11942, Saudi Arabia.
FAU - Nadeem, Muhammad Shahid
AU  - Nadeem MS
AUID- ORCID: 0000-0003-4112-0925
AD  - Department of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah 
      21589, Saudi Arabia.
FAU - Alzarea, Sami I
AU  - Alzarea SI
AUID- ORCID: 0000-0003-4007-4023
AD  - Department of Pharmacology, College of Pharmacy, Jouf University, Sakaka 72341, 
      Saudi Arabia.
FAU - Almalki, Waleed Hassan
AU  - Almalki WH
AD  - Department of Pharmacology, College of Pharmacy, Umm Al-Qura University, Makkah 
      21955, Saudi Arabia.
FAU - Tariq, Aqsa
AU  - Tariq A
AD  - Institute of Molecular Biology and Biotechnology (IMBB), The University of 
      Lahore, Lahore 54000, Pakistan.
FAU - Mubeen, Bismillah
AU  - Mubeen B
AUID- ORCID: 0000-0002-4095-6467
AD  - Institute of Molecular Biology and Biotechnology (IMBB), The University of 
      Lahore, Lahore 54000, Pakistan.
FAU - Murtaza, Bibi Nazia
AU  - Murtaza BN
AD  - Department of Zoology, Abbottabad University of Science and Technology (AUST), 
      Abbottabad 22310, Pakistan.
FAU - Iftikhar, Saima
AU  - Iftikhar S
AUID- ORCID: 0000-0002-0410-6959
AD  - School of Biological Sciences, University of Punjab, Lahore 54000, Pakistan.
FAU - Riaz, Naeem
AU  - Riaz N
AD  - Department of Pharmacy, COMSATS University, Abbottabad 22020, Pakistan.
FAU - Kazmi, Imran
AU  - Kazmi I
AUID- ORCID: 0000-0003-1881-5219
AD  - Department of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah 
      21589, Saudi Arabia.
LA  - eng
GR  - 224UQU4310387DSR03/Umm al-Qura University/
PT  - Journal Article
PT  - Review
DEP - 20221219
PL  - Switzerland
TA  - Nanomaterials (Basel)
JT  - Nanomaterials (Basel, Switzerland)
JID - 101610216
PMC - PMC9781272
OTO - NOTNLM
OT  - drug delivery
OT  - nanomedicine
OT  - nanoparticles
OT  - personalized medicine
OT  - therapeutics
COIS- The authors declare no conflict of interest.
EDAT- 2022/12/24 06:00
MHDA- 2022/12/24 06:01
PMCR- 2022/12/19
CRDT- 2022/12/23 01:52
PHST- 2022/11/11 00:00 [received]
PHST- 2022/12/04 00:00 [revised]
PHST- 2022/12/14 00:00 [accepted]
PHST- 2022/12/23 01:52 [entrez]
PHST- 2022/12/24 06:00 [pubmed]
PHST- 2022/12/24 06:01 [medline]
PHST- 2022/12/19 00:00 [pmc-release]
AID - nano12244494 [pii]
AID - nanomaterials-12-04494 [pii]
AID - 10.3390/nano12244494 [doi]
PST - epublish
SO  - Nanomaterials (Basel). 2022 Dec 19;12(24):4494. doi: 10.3390/nano12244494.