PMID- 36558418
OWN - NLM
STAT- MEDLINE
DCOM- 20221226
LR  - 20230308
IS  - 2072-6643 (Electronic)
IS  - 2072-6643 (Linking)
VI  - 14
IP  - 24
DP  - 2022 Dec 9
TI  - Association between Metabolic Phenotypes of Body Fatness and Incident Stroke: A 
      Prospective Cohort Study of Chinese Community Residents.
LID - 10.3390/nu14245258 [doi]
LID - 5258
AB  - This study aimed to assess the association of body mass index (BMI)-based and 
      waist circumference (WC)-based metabolic phenotypes with the risk of stroke among 
      Chinese community residents. A total of 34,294 participants (mean +/- standard 
      deviation age: 56.05 +/- 11.26 years) with no previous stroke diagnosis history 
      were included in this cohort study. BMI-based metabolic phenotypes were 
      classified into eight groups: metabolically healthy and normal weight (MHNW), 
      metabolically healthy and underweight (MHUW), metabolically healthy and 
      overweight (MHOW), metabolically healthy and obese (MHO), metabolically unhealthy 
      and normal weight (MUNW), metabolically unhealthy and underweight (MUUW), 
      metabolically unhealthy and overweight (MUOW), and metabolically unhealthy and 
      obese (MUO). WC-based metabolic phenotypes were classified into four groups: 
      metabolically healthy and normal WC (MHNWC), metabolically healthy and oversized 
      WC (MHOWC), metabolically unhealthy and normal WC (MUNWC), and metabolically 
      unhealthy and oversized WC (MUOWC). The association of these phenotypes with 
      developing stroke events was examined using proportional hazards models. A total 
      of 546 cases of first-stroke onset were recorded over a median follow-up time of 
      4.97 years. Compared with the reference group, the obesity phenotypes showed 
      higher risks for stroke. The adjusted HRs (95% CIs) of MHUW, MHOW, MHO, MUNW, 
      MUUW, MUOW, and MUO phenotypes were 1.01 (0.41, 2.49), 1.47 (1.09, 2.00), 1.33 
      (0.80, 2.22), 2.49 (1.87, 3.30), 3.92 (1.44, 10.72), 2.14 (1.64, 2.79), and 2.60 
      (1.91, 3.55), respectively. The adjusted HRs (95% CIs) of MHOWC, MUNWC, and MUOWC 
      were 1.41 (1.02, 1.94), 2.25 (1.76, 2.87), and 2.16 (1.63, 2.87), respectively. 
      The metabolic phenotypes defined by an alternative definition all showed 
      significant positive associations (except for MHUW), with the adjusted HR ranging 
      from 1.51 to 3.08 based on BMI and from 1.68 to 2.24 based on WC. The risk of 
      stroke increased with the increase in metabolic abnormality numbers in different 
      BMI and WC groups (all p trend < 0.001). The present study suggests that 
      maintaining normal body weight or WC and improving metabolic health are of great 
      significance in preventing cerebrovascular diseases.
FAU - Tang, Minhua
AU  - Tang M
AUID- ORCID: 0000-0003-4626-0230
AD  - Key Laboratory of Public Health Safety of Ministry of Education, Department of 
      Epidemiology, School of Public Health, Fudan University, Shanghai 200032, China.
AD  - Songjiang District Center for Disease Control and Prevention, Shanghai 201600, 
      China.
FAU - Zhao, Qi
AU  - Zhao Q
AUID- ORCID: 0000-0003-0140-3920
AD  - Key Laboratory of Public Health Safety of Ministry of Education, Department of 
      Epidemiology, School of Public Health, Fudan University, Shanghai 200032, China.
FAU - Yi, Kangqi
AU  - Yi K
AUID- ORCID: 0000-0002-2480-3727
AD  - Key Laboratory of Public Health Safety of Ministry of Education, Department of 
      Epidemiology, School of Public Health, Fudan University, Shanghai 200032, China.
FAU - Wu, Yiling
AU  - Wu Y
AD  - Songjiang District Center for Disease Control and Prevention, Shanghai 201600, 
      China.
FAU - Xiang, Yu
AU  - Xiang Y
AUID- ORCID: 0000-0001-7874-9298
AD  - Key Laboratory of Public Health Safety of Ministry of Education, Department of 
      Epidemiology, School of Public Health, Fudan University, Shanghai 200032, China.
FAU - Zaid, Maryam
AU  - Zaid M
AD  - Key Laboratory of Public Health Safety of Ministry of Education, Department of 
      Epidemiology, School of Public Health, Fudan University, Shanghai 200032, China.
FAU - Cui, Shuheng
AU  - Cui S
AUID- ORCID: 0000-0003-3015-7714
AD  - Key Laboratory of Public Health Safety of Ministry of Education, Department of 
      Epidemiology, School of Public Health, Fudan University, Shanghai 200032, China.
FAU - Su, Xuyan
AU  - Su X
AD  - Songjiang District Center for Disease Control and Prevention, Shanghai 201600, 
      China.
FAU - Yu, Yuting
AU  - Yu Y
AUID- ORCID: 0000-0001-8113-1851
AD  - Key Laboratory of Public Health Safety of Ministry of Education, Department of 
      Epidemiology, School of Public Health, Fudan University, Shanghai 200032, China.
FAU - Zhao, Genming
AU  - Zhao G
AD  - Key Laboratory of Public Health Safety of Ministry of Education, Department of 
      Epidemiology, School of Public Health, Fudan University, Shanghai 200032, China.
FAU - Jiang, Yonggen
AU  - Jiang Y
AD  - Songjiang District Center for Disease Control and Prevention, Shanghai 201600, 
      China.
LA  - eng
GR  - None/Local High Level Discipline Construction Project of Shanghai/
GR  - 2017YFC0907000/National Key Research and Development Program of China/
GR  - Grant No. GWV-10.1-XK16/Shanghai New Three-year Action Plan for Public Health/
PT  - Journal Article
DEP - 20221209
PL  - Switzerland
TA  - Nutrients
JT  - Nutrients
JID - 101521595
SB  - IM
MH  - Humans
MH  - Risk Factors
MH  - Overweight/complications
MH  - Cohort Studies
MH  - *Obesity, Metabolically Benign/diagnosis
MH  - Prospective Studies
MH  - Thinness/complications
MH  - East Asian People
MH  - Obesity/complications/epidemiology/diagnosis
MH  - Phenotype
MH  - Body Mass Index
MH  - *Stroke/epidemiology/complications
MH  - *Metabolic Syndrome/metabolism
PMC - PMC9785835
OTO - NOTNLM
OT  - body mass index
OT  - cohort study
OT  - obesity phenotypes
OT  - stroke
OT  - waist circumference
COIS- The authors declare no conflict of interest. The funders had no role in the 
      design of the study; in the collection, analyses, or interpretation of data; in 
      the writing of the manuscript; or in the decision to publish the results.
EDAT- 2022/12/24 06:00
MHDA- 2022/12/27 06:00
PMCR- 2022/12/09
CRDT- 2022/12/23 01:52
PHST- 2022/11/08 00:00 [received]
PHST- 2022/12/06 00:00 [revised]
PHST- 2022/12/07 00:00 [accepted]
PHST- 2022/12/23 01:52 [entrez]
PHST- 2022/12/24 06:00 [pubmed]
PHST- 2022/12/27 06:00 [medline]
PHST- 2022/12/09 00:00 [pmc-release]
AID - nu14245258 [pii]
AID - nutrients-14-05258 [pii]
AID - 10.3390/nu14245258 [doi]
PST - epublish
SO  - Nutrients. 2022 Dec 9;14(24):5258. doi: 10.3390/nu14245258.