PMID- 36558551
OWN - NLM
STAT- MEDLINE
DCOM- 20221226
LR  - 20221227
IS  - 2072-6643 (Electronic)
IS  - 2072-6643 (Linking)
VI  - 14
IP  - 24
DP  - 2022 Dec 19
TI  - Effects of Bifidobacterium with the Ability of 2'-Fucosyllactose Utilization on 
      Intestinal Microecology of Mice.
LID - 10.3390/nu14245392 [doi]
LID - 5392
AB  - In breast milk, 2'-Fucosyllactose (2'FL) is the most abundant breast milk 
      oligosaccharide and can selectively promote the proliferation of bifidobacteria. 
      This study aimed to explore the effect of ifidobacterial with different 
      utilization capacities of 2'FL on the intestinal microecology of mice. 
      Furthermore, the effects of ifidobacterial with different 2'FL utilization 
      capabilities on mice gut microbiota under the competitive pressure of 2'FL as a 
      carbon source were explored. Compared with the control group, 2'FL, 
      Bifidobacterium (B.) bifidum M130R01M51 + 2'FL, B. longum subsp. Longum CCFM752, 
      and CCFM752 + 2'FL treatments significantly decreased the food intake. Moreover, 
      the water intake, body weight, and fecal water content in all groups showed no 
      significant difference compared with the control group. The combination of B. 
      longum subsp. longum CCFM752 and 2'FL can significantly increase the levels of 
      pro-inflammatory and anti-inflammatory factors. B. bifidum M130R01M51 and mixed 
      strains combined with 2'FL significantly increased the contents of acetic acid 
      and isobutyric acid. The results showed that B. bifidum M130R01M51, B. breve 
      FHuNCS6M1, B. longum subsp. longum CCFM752, and B. longum subsp. infantis SDZC2M4 
      combined with 2'FL significantly increased the species richness of the gut 
      microbiota. Moreover, B. longum subsp. longum CCFM752 and B. longum subsp. 
      infantis SDZC2M4 significantly increased the abundance of Faecalibaculum and 
      Bifidobacterium, respectively. In conclusion, exploring the impact on intestinal 
      microecology can provide theoretical guidance for the development of personalized 
      prebiotics for different bifidobacteria, which has the potential to improve the 
      ecological imbalance of infant gut microbiota.
FAU - Mao, Bingyong
AU  - Mao B
AD  - State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 
      214122, China.
AD  - School of Food Science and Technology, Jiangnan University, Wuxi 214122, China.
FAU - He, Zhujun
AU  - He Z
AD  - State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 
      214122, China.
AD  - School of Food Science and Technology, Jiangnan University, Wuxi 214122, China.
FAU - Chen, Yang
AU  - Chen Y
AD  - State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 
      214122, China.
AD  - School of Food Science and Technology, Jiangnan University, Wuxi 214122, China.
FAU - Stanton, Catherine
AU  - Stanton C
AUID- ORCID: 0000-0002-6724-7011
AD  - International Joint Research Center for Probiotics & Gut Health, Jiangnan 
      University, Wuxi 214122, China.
AD  - APC Microbiome Ireland, University College Cork, T12 R229 Cork, Ireland.
AD  - Teagasc Food Research Centre, Moorepark, Co., P61 C996 Cork, Ireland.
FAU - Ross, Reynolds Paul
AU  - Ross RP
AUID- ORCID: 0000-0003-4876-8839
AD  - International Joint Research Center for Probiotics & Gut Health, Jiangnan 
      University, Wuxi 214122, China.
AD  - APC Microbiome Ireland, University College Cork, T12 R229 Cork, Ireland.
FAU - Zhao, Jianxin
AU  - Zhao J
AD  - State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 
      214122, China.
AD  - School of Food Science and Technology, Jiangnan University, Wuxi 214122, China.
FAU - Chen, Wei
AU  - Chen W
AD  - State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 
      214122, China.
AD  - School of Food Science and Technology, Jiangnan University, Wuxi 214122, China.
AD  - National Engineering Research Center for Functional Food, Jiangnan University, 
      Wuxi 214122, China.
FAU - Yang, Bo
AU  - Yang B
AUID- ORCID: 0000-0002-1347-3718
AD  - State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 
      214122, China.
AD  - School of Food Science and Technology, Jiangnan University, Wuxi 214122, China.
AD  - International Joint Research Center for Probiotics & Gut Health, Jiangnan 
      University, Wuxi 214122, China.
LA  - eng
GR  - 2021YFD2100700/National Key R&D Program of China/
GR  - 32021005, 31820103010/National Natural Science Foundation of China/
PT  - Journal Article
DEP - 20221219
PL  - Switzerland
TA  - Nutrients
JT  - Nutrients
JID - 101521595
RN  - XO2533XO8R (2'-fucosyllactose)
RN  - 0 (Trisaccharides)
RN  - 0 (Oligosaccharides)
SB  - IM
MH  - Animals
MH  - Mice
MH  - *Bifidobacterium
MH  - Trisaccharides/pharmacology
MH  - Oligosaccharides/pharmacology
MH  - Milk, Human
MH  - *Bifidobacterium bifidum
PMC - PMC9785880
OTO - NOTNLM
OT  - 2'-fucosyllactose
OT  - Bifidobacterium
OT  - intestinal microecology
OT  - mixed strains
COIS- The authors declare no conflict of interest.
EDAT- 2022/12/24 06:00
MHDA- 2022/12/27 06:00
PMCR- 2022/12/19
CRDT- 2022/12/23 01:53
PHST- 2022/11/19 00:00 [received]
PHST- 2022/12/08 00:00 [revised]
PHST- 2022/12/15 00:00 [accepted]
PHST- 2022/12/23 01:53 [entrez]
PHST- 2022/12/24 06:00 [pubmed]
PHST- 2022/12/27 06:00 [medline]
PHST- 2022/12/19 00:00 [pmc-release]
AID - nu14245392 [pii]
AID - nutrients-14-05392 [pii]
AID - 10.3390/nu14245392 [doi]
PST - epublish
SO  - Nutrients. 2022 Dec 19;14(24):5392. doi: 10.3390/nu14245392.