PMID- 36559306
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20221227
IS  - 1999-4923 (Print)
IS  - 1999-4923 (Electronic)
IS  - 1999-4923 (Linking)
VI  - 14
IP  - 12
DP  - 2022 Dec 15
TI  - Expandable Drug Delivery Systems Based on Shape Memory Polymers: Impact of Film 
      Coating on Mechanical Properties and Release and Recovery Performance.
LID - 10.3390/pharmaceutics14122814 [doi]
LID - 2814
AB  - Retentive drug delivery systems (DDSs) are intended for prolonged residence and 
      release inside hollow muscular organs, to achieve either local or systemic 
      therapeutic goals. Recently, formulations based on shape memory polymers (SMPs) 
      have gained attention in view of their special ability to recover a shape with 
      greater spatial encumbrance at the target organ (e.g., urinary bladder or 
      stomach), triggered by contact with biological fluids at body temperature. In 
      this work, poly(vinyl alcohol) (PVA), a pharmaceutical-grade SMP previously shown 
      to be an interesting 4D printing candidate, was employed to fabricate expandable 
      organ-retentive prototypes by hot melt extrusion. With the aim of improving the 
      mechanical resistance of the expandable DDS and slowing down relevant drug 
      release, the application of insoluble permeable coatings based on either 
      Eudragit((R)) RS/RL or Eudragit((R)) NE was evaluated using simple I-shaped 
      specimens. The impact of the composition and thickness of the coating on the 
      shape memory, swelling, and release behavior as well as on the mechanical 
      properties of these specimens was thoroughly investigated and the effectiveness 
      of the proposed strategy was demonstrated by the results obtained.
FAU - Uboldi, Marco
AU  - Uboldi M
AUID- ORCID: 0000-0003-0179-2233
AD  - Sezione di Tecnologia e Legislazione Farmaceutiche "Maria Edvige Sangalli", 
      Dipartimento di Scienze Farmaceutiche, Universita degli Studi di Milano, Via G. 
      Colombo 71, 20133 Milano, Italy.
FAU - Pasini, Chiara
AU  - Pasini C
AUID- ORCID: 0000-0001-7478-239X
AD  - Dipartimento di Ingegneria Meccanica e Industriale, Universita degli Studi di 
      Brescia, Via Branze 38, 25123 Brescia, Italy.
FAU - Pandini, Stefano
AU  - Pandini S
AD  - Dipartimento di Ingegneria Meccanica e Industriale, Universita degli Studi di 
      Brescia, Via Branze 38, 25123 Brescia, Italy.
FAU - Baldi, Francesco
AU  - Baldi F
AD  - Dipartimento di Ingegneria Meccanica e Industriale, Universita degli Studi di 
      Brescia, Via Branze 38, 25123 Brescia, Italy.
FAU - Briatico-Vangosa, Francesco
AU  - Briatico-Vangosa F
AUID- ORCID: 0000-0002-7088-1064
AD  - Dipartimento di Chimica, Materiali e Ingegneria Chimica "G. Natta", Politecnico 
      di Milano, Piazza Leonardo da Vinci 32, 20133 Milano, Italy.
FAU - Inverardi, Nicoletta
AU  - Inverardi N
AUID- ORCID: 0000-0003-3550-9299
AD  - Dipartimento di Ingegneria Meccanica e Industriale, Universita degli Studi di 
      Brescia, Via Branze 38, 25123 Brescia, Italy.
FAU - Maroni, Alessandra
AU  - Maroni A
AD  - Sezione di Tecnologia e Legislazione Farmaceutiche "Maria Edvige Sangalli", 
      Dipartimento di Scienze Farmaceutiche, Universita degli Studi di Milano, Via G. 
      Colombo 71, 20133 Milano, Italy.
FAU - Moutaharrik, Saliha
AU  - Moutaharrik S
AUID- ORCID: 0000-0001-8885-8500
AD  - Sezione di Tecnologia e Legislazione Farmaceutiche "Maria Edvige Sangalli", 
      Dipartimento di Scienze Farmaceutiche, Universita degli Studi di Milano, Via G. 
      Colombo 71, 20133 Milano, Italy.
FAU - Melocchi, Alice
AU  - Melocchi A
AUID- ORCID: 0000-0001-5602-3314
AD  - Sezione di Tecnologia e Legislazione Farmaceutiche "Maria Edvige Sangalli", 
      Dipartimento di Scienze Farmaceutiche, Universita degli Studi di Milano, Via G. 
      Colombo 71, 20133 Milano, Italy.
FAU - Gazzaniga, Andrea
AU  - Gazzaniga A
AD  - Sezione di Tecnologia e Legislazione Farmaceutiche "Maria Edvige Sangalli", 
      Dipartimento di Scienze Farmaceutiche, Universita degli Studi di Milano, Via G. 
      Colombo 71, 20133 Milano, Italy.
FAU - Zema, Lucia
AU  - Zema L
AUID- ORCID: 0000-0001-8405-226X
AD  - Sezione di Tecnologia e Legislazione Farmaceutiche "Maria Edvige Sangalli", 
      Dipartimento di Scienze Farmaceutiche, Universita degli Studi di Milano, Via G. 
      Colombo 71, 20133 Milano, Italy.
LA  - eng
PT  - Journal Article
DEP - 20221215
PL  - Switzerland
TA  - Pharmaceutics
JT  - Pharmaceutics
JID - 101534003
PMC - PMC9786903
OTO - NOTNLM
OT  - expandable drug delivery system
OT  - film-coating
OT  - fused deposition modeling
OT  - hot melt extrusion
OT  - poly(vinyl alcohol) (PVA)
OT  - retentive drug delivery system
OT  - shape memory polymer
COIS- The authors declare no conflict of interest.
EDAT- 2022/12/24 06:00
MHDA- 2022/12/24 06:01
PMCR- 2022/12/15
CRDT- 2022/12/23 01:57
PHST- 2022/11/01 00:00 [received]
PHST- 2022/12/09 00:00 [revised]
PHST- 2022/12/13 00:00 [accepted]
PHST- 2022/12/23 01:57 [entrez]
PHST- 2022/12/24 06:00 [pubmed]
PHST- 2022/12/24 06:01 [medline]
PHST- 2022/12/15 00:00 [pmc-release]
AID - pharmaceutics14122814 [pii]
AID - pharmaceutics-14-02814 [pii]
AID - 10.3390/pharmaceutics14122814 [doi]
PST - epublish
SO  - Pharmaceutics. 2022 Dec 15;14(12):2814. doi: 10.3390/pharmaceutics14122814.