PMID- 36559799
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20221227
IS  - 2073-4360 (Electronic)
IS  - 2073-4360 (Linking)
VI  - 14
IP  - 24
DP  - 2022 Dec 12
TI  - A Review on Biomedical Application of Polysaccharide-Based Hydrogels with a Focus 
      on Drug Delivery Systems.
LID - 10.3390/polym14245432 [doi]
LID - 5432
AB  - Over the last years of research on drug delivery systems (DDSs), natural 
      polymer-based hydrogels have shown many scientific advances due to their 
      intrinsic properties and a wide variety of potential applications. While drug 
      efficacy and cytotoxicity play a key role, adopting a proper DDS is crucial to 
      preserve the drug along the route of administration and possess desired 
      therapeutic effect at the targeted site. Thus, drug delivery technology can be 
      used to overcome the difficulties of maintaining drugs at a physiologically 
      related serum concentration for prolonged periods. Due to their outstanding 
      biocompatibility, polysaccharides have been thoroughly researched as a biological 
      material for DDS advancement. To formulate a modified DDS, polysaccharides can 
      cross-link with different molecules, resulting in hydrogels. According to our 
      recent findings, targeted drug delivery at a certain spot occurs due to external 
      stimulation such as temperature, pH, glucose, or light. As an adjustable 
      biomedical device, the hydrogel has tremendous potential for nanotech 
      applications in involved health areas such as pharmaceutical and biomedical 
      engineering. An overview of hydrogel characteristics and functionalities is 
      provided in this review. We focus on discussing the various kinds of 
      hydrogel-based systems on their potential for effectively delivering drugs that 
      are made of polysaccharides.
FAU - Farasati Far, Bahareh
AU  - Farasati Far B
AD  - Research Laboratory of Green Organic Synthesis and Polymers, Department of 
      Chemistry, Iran University of Science and Technology, Tehran 1684613114, Iran.
FAU - Naimi-Jamal, Mohammad Reza
AU  - Naimi-Jamal MR
AUID- ORCID: 0000-0002-8305-7234
AD  - Research Laboratory of Green Organic Synthesis and Polymers, Department of 
      Chemistry, Iran University of Science and Technology, Tehran 1684613114, Iran.
FAU - Safaei, Maryam
AU  - Safaei M
AD  - Department of Pharmacology, Faculty of Pharmacy, Eastern Mediterranean 
      University, Famagusta 99628, Turkey.
FAU - Zarei, Kimia
AU  - Zarei K
AD  - Faculty of Pharmacy and Pharmaceutical Sciences, Tehran Medical Sciences, Islamic 
      Azad University, Tehran 1916893813, Iran.
FAU - Moradi, Marzieh
AU  - Moradi M
AD  - Faculty of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran 
      1985717443, Iran.
FAU - Yazdani Nezhad, Hamed
AU  - Yazdani Nezhad H
AD  - Department of Mechanical Engineering & Aeronautics, City University of London, 
      London EC1V 0HB, UK.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20221212
PL  - Switzerland
TA  - Polymers (Basel)
JT  - Polymers
JID - 101545357
PMC - PMC9784417
OTO - NOTNLM
OT  - bioengineering
OT  - biomedical application
OT  - drug delivery
OT  - hydrogel
OT  - polysaccharide
COIS- The authors declare no conflict of interest.
EDAT- 2022/12/24 06:00
MHDA- 2022/12/24 06:01
PMCR- 2022/12/12
CRDT- 2022/12/23 02:00
PHST- 2022/11/01 00:00 [received]
PHST- 2022/12/02 00:00 [revised]
PHST- 2022/12/05 00:00 [accepted]
PHST- 2022/12/23 02:00 [entrez]
PHST- 2022/12/24 06:00 [pubmed]
PHST- 2022/12/24 06:01 [medline]
PHST- 2022/12/12 00:00 [pmc-release]
AID - polym14245432 [pii]
AID - polymers-14-05432 [pii]
AID - 10.3390/polym14245432 [doi]
PST - epublish
SO  - Polymers (Basel). 2022 Dec 12;14(24):5432. doi: 10.3390/polym14245432.