PMID- 36560396
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20221227
IS  - 2076-393X (Print)
IS  - 2076-393X (Electronic)
IS  - 2076-393X (Linking)
VI  - 10
IP  - 12
DP  - 2022 Nov 23
TI  - A Novel Finding of an HLA Allele's and a Haplotype's Relationship with SARS-CoV-2 
      Vaccine-Associated Subacute Thyroiditis.
LID - 10.3390/vaccines10121986 [doi]
LID - 1986
AB  - Subacute thyroiditis (SAT) is a thyroid disease associated with viral infections. 
      Its relationship with major histocompatibility complex (MHC) antigens was shown 
      before. SAT cases triggered by different types of severe acute respiratory 
      syndrome coronavirus 2 (SARS-CoV-2) vaccines have been reported. In this study, 
      human leukocyte antigen (HLA) genotypes of 27 SAT patients (13 vaccine-associated 
      (V-SAT) and 14 non-SARS-CoV-2-infection non-vaccine-associated (non-V-SAT)) were 
      compared with those of 362 healthy donors. HLA analyses were performed with 
      low-resolution DNA-based sequence-specific oligonucleotide or sequence-specific 
      primer methods. Statistical analyses were performed using IBM SPSS Statistics 25 
      and Stata/MP 14.1 with the hapipf function. Allele and haplotype frequencies were 
      estimated by PyPop and gene[RATE] tool programs. The allele frequencies of 
      HLA-A*11, HLA-B*35, and HLA-C*04 were higher in the patient groups. Both the 
      allele frequency of HLA-A*11 and the haplotype frequency of A*11-B*35-C*04 were 
      higher in the V-SAT group. The A*11-B*35-C*04 haplotype, including all three loci 
      of MHC class I genes, is shown to be associated with the disease for the first 
      time, especially in the V-SAT group. This finding will contribute to a better 
      understanding of the etiopathogenesis of vaccine-associated SAT and the role of 
      HLA genotypes in the functioning mechanisms of the SARS-CoV-2 vaccines.
FAU - Sahin Tekin, Melisa
AU  - Sahin Tekin M
AD  - Department of Internal Medicine, Faculty of Medicine, Eskisehir Osmangazi 
      University, 26040 Eskisehir, Turkey.
FAU - Yorulmaz, Goknur
AU  - Yorulmaz G
AD  - Department of Internal Medicine, Division of Endocrinology and Metabolism, 
      Faculty of Medicine, Eskisehir Osmangazi University, 26040 Eskisehir, Turkey.
FAU - Yantir, Emel
AU  - Yantir E
AD  - Department of Immunology, Faculty of Medicine, Eskisehir Osmangazi University, 
      26040 Eskisehir, Turkey.
FAU - Gunduz, Eren
AU  - Gunduz E
AD  - Department of Internal Medicine, Division of Hematology, Faculty of Medicine, 
      Eskisehir Osmangazi University, 26040 Eskisehir, Turkey.
FAU - Colak, Ertugrul
AU  - Colak E
AD  - Department of Biostatistics, Faculty of Medicine, Eskisehir Osmangazi University, 
      26040 Eskisehir, Turkey.
LA  - eng
PT  - Journal Article
DEP - 20221123
PL  - Switzerland
TA  - Vaccines (Basel)
JT  - Vaccines
JID - 101629355
PMC - PMC9788374
OTO - NOTNLM
OT  - HLA-A*11
OT  - HLA-A*11-B*35-C*04 haplotype
OT  - MHC class I
OT  - SARS-CoV-2
OT  - mRNA vaccines
OT  - subacute thyroiditis
COIS- The authors declare no conflict of interest.
EDAT- 2022/12/24 06:00
MHDA- 2022/12/24 06:01
PMCR- 2022/11/23
CRDT- 2022/12/23 02:04
PHST- 2022/08/27 00:00 [received]
PHST- 2022/11/14 00:00 [revised]
PHST- 2022/11/16 00:00 [accepted]
PHST- 2022/12/23 02:04 [entrez]
PHST- 2022/12/24 06:00 [pubmed]
PHST- 2022/12/24 06:01 [medline]
PHST- 2022/11/23 00:00 [pmc-release]
AID - vaccines10121986 [pii]
AID - vaccines-10-01986 [pii]
AID - 10.3390/vaccines10121986 [doi]
PST - epublish
SO  - Vaccines (Basel). 2022 Nov 23;10(12):1986. doi: 10.3390/vaccines10121986.