PMID- 36561561
OWN - NLM
STAT- MEDLINE
DCOM- 20221226
LR  - 20230127
IS  - 1664-2392 (Print)
IS  - 1664-2392 (Electronic)
IS  - 1664-2392 (Linking)
VI  - 13
DP  - 2022
TI  - Systemic immune-inflammation index is associated with diabetic kidney disease in 
      Type 2 diabetes mellitus patients: Evidence from NHANES 2011-2018.
PG  - 1071465
LID - 10.3389/fendo.2022.1071465 [doi]
LID - 1071465
AB  - OBJECTIVE: Diabetic kidney disease (DKD) is the most common chronic kidney 
      disease (CKD) and has the highest prevalence of end-stage kidney disease (ESKD) 
      globally, owing mostly to the rise in Type 2 diabetes mellitus (T2DM) correlated 
      with obesity. Current research suggested that the immune response and 
      inflammation may play a role in the pathophysiology of T2DM. The systemic 
      immune-inflammation index (SII) is a novel and integrated inflammatory biomarker 
      that has not yet been linked to DKD. We aimed to identify the potential 
      relationship between SII and DKD. METHODS: In the National Health and Nutrition 
      Examination Survey (NHANES) between 2011 and 2018, the current cross-sectional 
      study was conducted among adults with T2DM. SII was calculated as the platelet 
      count x neutrophil count/lymphocyte count. DKD was diagnosed with impaired 
      glomerular filtration rate (< 60 mL/min/1.73 m(2) assessed by using the Chronic 
      Kidney Disease Epidemiology Collaboration algorithm), albuminuria (urine albumin 
      to creatinine ratio >/= 30 mg/g), or both in T2DM patients. To investigate the 
      independent association between SII and DKD, weighted univariate and 
      multivariable logistic regression analyses and subgroup analyses were performed. 
      RESULTS: The study involved 3937 patients in total, of whom 1510 (38.4%) had DKD 
      for the diagnosis. After adjustment for covariates, multivariable logistic 
      regression revealed that a high SII level was associated with increased 
      likelihood of DKD (OR = 1.42, 95% CI: 1.10-1.83, P = 0.01). Subgroup analyses and 
      interaction tests revealed that age, gender, estimated glomerular filtration rate 
      (eGFR), urine albumin-to-creatinine ratio (ACR), body mass index (BMI), 
      hypertension, hyperlipidemia, anti-inflammation therapy (yes or no), metformin 
      use (yes or no), and insulin use (yes or no) had no significant dependence on 
      this positive relationship (all p for interaction >0.05). CONCLUSIONS: Our 
      results indicate that the higher SII level is associated with DKD in T2DM 
      patients. The SII could be a cost-effective and straightforward approach to 
      detecting DKD. This needs to be verified in further prospective investigations.
CI  - Copyright (c) 2022 Guo, Song, Sun, Du, Cai, You, Fu and Shao.
FAU - Guo, Wencong
AU  - Guo W
AD  - Laboratory of Nephrology & Department of Nephrology, The Affiliated Qingdao 
      Municipal Hospital of Qingdao University, Qingdao, Shandong, China.
FAU - Song, Yancheng
AU  - Song Y
AD  - Department of Gastrointestinal Surgery, The Affiliated Hospital of Qingdao 
      University, Qingdao, Shandong, China.
FAU - Sun, Yan
AU  - Sun Y
AD  - Laboratory of Nephrology & Department of Nephrology, The Affiliated Qingdao 
      Municipal Hospital of Qingdao University, Qingdao, Shandong, China.
FAU - Du, Huasheng
AU  - Du H
AD  - Laboratory of Nephrology & Department of Nephrology, The Affiliated Qingdao 
      Municipal Hospital of Qingdao University, Qingdao, Shandong, China.
FAU - Cai, Yan
AU  - Cai Y
AD  - Laboratory of Nephrology & Department of Nephrology, The Affiliated Qingdao 
      Municipal Hospital of Qingdao University, Qingdao, Shandong, China.
FAU - You, Qingqing
AU  - You Q
AD  - Laboratory of Nephrology & Department of Nephrology, The Affiliated Qingdao 
      Municipal Hospital of Qingdao University, Qingdao, Shandong, China.
FAU - Fu, Haixia
AU  - Fu H
AD  - Laboratory of Nephrology & Department of Nephrology, The Affiliated Qingdao 
      Municipal Hospital of Qingdao University, Qingdao, Shandong, China.
FAU - Shao, Leping
AU  - Shao L
AD  - Laboratory of Nephrology & Department of Nephrology, The Affiliated Qingdao 
      Municipal Hospital of Qingdao University, Qingdao, Shandong, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20221206
PL  - Switzerland
TA  - Front Endocrinol (Lausanne)
JT  - Frontiers in endocrinology
JID - 101555782
RN  - AYI8EX34EU (Creatinine)
RN  - 0 (Albumins)
SB  - IM
MH  - Adult
MH  - Humans
MH  - *Diabetic Nephropathies/diagnosis/epidemiology/etiology
MH  - *Diabetes Mellitus, Type 2/complications/epidemiology
MH  - Nutrition Surveys
MH  - Creatinine
MH  - Cross-Sectional Studies
MH  - Inflammation/epidemiology/complications
MH  - *Renal Insufficiency, Chronic/complications/epidemiology
MH  - Albumins
PMC - PMC9763451
OTO - NOTNLM
OT  - NHANES
OT  - diabetic kidney disease
OT  - population-based study
OT  - systemic immune-inflammation index
OT  - type 2 diabetes mellitus
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/12/24 06:00
MHDA- 2022/12/27 06:00
PMCR- 2022/01/01
CRDT- 2022/12/23 02:30
PHST- 2022/10/19 00:00 [received]
PHST- 2022/11/21 00:00 [accepted]
PHST- 2022/12/23 02:30 [entrez]
PHST- 2022/12/24 06:00 [pubmed]
PHST- 2022/12/27 06:00 [medline]
PHST- 2022/01/01 00:00 [pmc-release]
AID - 10.3389/fendo.2022.1071465 [doi]
PST - epublish
SO  - Front Endocrinol (Lausanne). 2022 Dec 6;13:1071465. doi: 
      10.3389/fendo.2022.1071465. eCollection 2022.