PMID- 36562807
OWN - NLM
STAT- MEDLINE
DCOM- 20230412
LR  - 20230412
IS  - 1437-1596 (Electronic)
IS  - 0937-9827 (Linking)
VI  - 137
IP  - 3
DP  - 2023 May
TI  - Role of integrin and its potential as a novel postmortem biomarker in traumatic 
      axonal injury.
PG  - 843-849
LID - 10.1007/s00414-022-02938-3 [doi]
AB  - Traumatic axonal injury (TAI) accounts for a large proportion of the mortality of 
      traumatic brain injury (TBI). The diagnosis of TAI is currently of limited use 
      for medicolegal purposes. It is known that axons in TAI are diffusely damaged by 
      secondary processes other than direct head injury. However, the 
      physiopathological mechanism of TAI is still elusive. The present study used RGD 
      peptide, an antagonist of the mechanotransduction protein integrin, to explore 
      the role of integrin-transmitted mechanical signalling in the pathogenesis of rat 
      TAI. The rats were subjected to a linearly accelerating load, and changes in 
      beta-amyloid precursor protein (beta-APP) expression, skeleton ultrastructure, 
      skeleton protein neurofilament light (NF-L), and alpha-tubulin in the brainstem were 
      observed, indicating that RGD could relieve the severity of axonal injury in TAI 
      rats. In addition, the expression of beta-integrin was stronger and centralized in 
      the brainstem of the deceased died from TAI compared to other nonviolent causes. 
      This study examined the pathophysiology and biomechanics of TAI and assessed the 
      role of integrin in the injury of microtubules and neurofilaments in TAI. Thus, 
      we propose that integrin-mediated cytoskeletal injury plays an important role in 
      TAI and that integrin has the potential as a biomarker for TAI.
CI  - (c) 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, 
      part of Springer Nature.
FAU - Yijie, Duan
AU  - Yijie D
AD  - Department of Forensic Medicine, Tongji Medical College, Huazhong University of 
      Science and Technology, No. 13 Hangkong Road, Hankou, Wuhan, People's Republic of 
      China.
FAU - Weisheng, Huang
AU  - Weisheng H
AD  - Department of Forensic Medicine, Tongji Medical College, Huazhong University of 
      Science and Technology, No. 13 Hangkong Road, Hankou, Wuhan, People's Republic of 
      China.
FAU - Ji, Zhang
AU  - Ji Z
AD  - Department of Forensic Medicine, Tongji Medical College, Huazhong University of 
      Science and Technology, No. 13 Hangkong Road, Hankou, Wuhan, People's Republic of 
      China.
FAU - Jiao, Mu
AU  - Jiao M
AD  - Department of Forensic Medicine, Tongji Medical College, Huazhong University of 
      Science and Technology, No. 13 Hangkong Road, Hankou, Wuhan, People's Republic of 
      China.
FAU - Yiwu, Zhou
AU  - Yiwu Z
AD  - Department of Forensic Medicine, Tongji Medical College, Huazhong University of 
      Science and Technology, No. 13 Hangkong Road, Hankou, Wuhan, People's Republic of 
      China. zhouyiwu@outlook.com.
FAU - Hongmei, Dong
AU  - Hongmei D
AUID- ORCID: 0000-0002-1086-1002
AD  - Department of Forensic Medicine, Tongji Medical College, Huazhong University of 
      Science and Technology, No. 13 Hangkong Road, Hankou, Wuhan, People's Republic of 
      China. hongmeidong1@hotmail.com.
LA  - eng
GR  - 81102298/National Natural Science Foundation Youth Fund/
GR  - 81471821/National Natural Science Foundation of China/
PT  - Journal Article
DEP - 20221223
PL  - Germany
TA  - Int J Legal Med
JT  - International journal of legal medicine
JID - 9101456
RN  - 0 (Biomarkers)
SB  - IM
MH  - Rats
MH  - Animals
MH  - Rats, Sprague-Dawley
MH  - *Brain Injuries/pathology
MH  - Mechanotransduction, Cellular
MH  - Immunohistochemistry
MH  - Axons/metabolism/pathology
MH  - Biomarkers/metabolism
MH  - *Diffuse Axonal Injury/etiology/metabolism/pathology
OTO - NOTNLM
OT  - Brainstem
OT  - Integrin
OT  - Microtubule
OT  - Neurofilament
OT  - Traumatic axonal injury
EDAT- 2022/12/24 06:00
MHDA- 2023/04/12 06:41
CRDT- 2022/12/23 11:13
PHST- 2022/04/08 00:00 [received]
PHST- 2022/12/07 00:00 [accepted]
PHST- 2023/04/12 06:41 [medline]
PHST- 2022/12/24 06:00 [pubmed]
PHST- 2022/12/23 11:13 [entrez]
AID - 10.1007/s00414-022-02938-3 [pii]
AID - 10.1007/s00414-022-02938-3 [doi]
PST - ppublish
SO  - Int J Legal Med. 2023 May;137(3):843-849. doi: 10.1007/s00414-022-02938-3. Epub 
      2022 Dec 23.