PMID- 36564084
OWN - NLM
STAT- MEDLINE
DCOM- 20221227
LR  - 20230103
IS  - 2052-4897 (Electronic)
IS  - 2052-4897 (Linking)
VI  - 10
IP  - 6
DP  - 2022 Dec
TI  - Ethnic differences in urinary monocyte chemoattractant protein-1 and heparanase-1 
      levels in individuals with type 2 diabetes: the HELIUS study.
LID - 10.1136/bmjdrc-2022-003003 [doi]
LID - e003003
AB  - INTRODUCTION: We aimed to investigate ethnic differences in two urinary 
      inflammatory markers in participants with type 2 diabetes mellitus (T2DM). 
      RESEARCH DESIGN AND METHODS: We included 55 Dutch, 127 South-Asian Surinamese, 92 
      African Surinamese, 62 Ghanaian, 74 Turkish and 88 Moroccan origin participants 
      with T2DM from the HEalthy LIfe in an Urban Setting study. Using linear 
      regression analyses, we investigated differences in urinary monocyte 
      chemoattractant protein-1 (MCP-1) and heparanase-1 (HPSE-1) levels across ethnic 
      minorities compared with Dutch. Associations between the urinary markers and 
      albuminuria (albumin:creatinine ratio (ACR)) was investigated per ethnicity. 
      RESULTS: Urinary MCP-1 levels were higher in the Moroccan participants (0.15 log 
      ng/mmol, 95% CI 0.05 to 0.26) compared with Dutch after multiple adjustments. 
      Urinary HPSE-1 levels were lower in the African Surinamese and Ghanaian 
      participants compared with the Dutch, with a difference of -0.16 log mU/mmol 
      (95% CI -0.29 to -0.02) in African Surinamese and -0.16 log mU/mmol (95% CI -0.31 
      to -0.00) in Ghanaian after multiple adjustments. In all ethnic groups except the 
      Dutch and Ghanaian participants, MCP-1 was associated with ACR. This association 
      remained strongest after multiple adjustment in South-Asian and African 
      Surinamese participants, with an increase in log ACR of 1.03% (95% CI 0.58 to 
      1.47) and 1.23% (95% CI 0.52 to 1.94) if log MCP-1 increased 1%. Only in the 
      Dutch participants, an association between HPSE-1 and ACR was found, with 
      increase in log ACR of 0.40% (95% CI 0.04 to 0.76) if log HPSE-1 increased 1%. 
      CONCLUSIONS: We found ethnic differences in urinary MCP-1 and HPSE-1 levels, in a 
      multi-ethnic cohort of participants with T2DM. In addition, we found ethnic 
      differences in the association of MCP-1 and HPSE-1 levels with albuminuria. These 
      findings suggest differences in renal inflammation across ethnic groups.
CI  - (c) Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No 
      commercial re-use. See rights and permissions. Published by BMJ.
FAU - van der Velden, Anouk I M
AU  - van der Velden AIM
AUID- ORCID: 0000-0001-7199-6026
AD  - Department of Internal Medicine (Nephrology) and Einthoven Laboratory of Vascular 
      and Regenerative Medicine, Leiden University Medical Center, Leiden, The 
      Netherlands a.i.m.van_der_velden@lumc.nl.
FAU - van den Berg, Bernard M
AU  - van den Berg BM
AD  - Department of Internal Medicine (Nephrology) and Einthoven Laboratory of Vascular 
      and Regenerative Medicine, Leiden University Medical Center, Leiden, The 
      Netherlands.
FAU - van den Born, B J
AU  - van den Born BJ
AD  - Internal Medicine, Amsterdam UMC-Locatie AMC, Amsterdam, The Netherlands.
FAU - Galenkamp, Henrike
AU  - Galenkamp H
AD  - Public and Occupational Health, Amsterdam UMC-Locatie AMC, Amsterdam, The 
      Netherlands.
FAU - Ijpelaar, Daphne H T
AU  - Ijpelaar DHT
AD  - Department of Internal Medicine (Nephrology) and Einthoven Laboratory of Vascular 
      and Regenerative Medicine, Leiden University Medical Center, Leiden, The 
      Netherlands.
AD  - Department of Internal Medicine and Nephrology, Groene Hart Hospital, Gouda, The 
      Netherlands.
FAU - Rabelink, Ton J
AU  - Rabelink TJ
AUID- ORCID: 0000-0001-6780-5186
AD  - Department of Internal Medicine (Nephrology) and Einthoven Laboratory of Vascular 
      and Regenerative Medicine, Leiden University Medical Center, Leiden, The 
      Netherlands.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - BMJ Open Diabetes Res Care
JT  - BMJ open diabetes research & care
JID - 101641391
RN  - EC 3.2.1.- (heparanase)
RN  - 0 (Chemokine CCL2)
SB  - IM
MH  - Humans
MH  - *Diabetes Mellitus, Type 2
MH  - Ghana
MH  - Albuminuria
MH  - Chemokine CCL2
PMC - PMC9791388
OTO - NOTNLM
OT  - MCP-1
OT  - diabetes mellitus, type 2
OT  - ethnicity
OT  - inflammation
COIS- Competing interests: None declared.
EDAT- 2022/12/24 06:00
MHDA- 2022/12/28 06:00
PMCR- 2022/12/23
CRDT- 2022/12/23 20:42
PHST- 2022/06/23 00:00 [received]
PHST- 2022/11/05 00:00 [accepted]
PHST- 2022/12/23 20:42 [entrez]
PHST- 2022/12/24 06:00 [pubmed]
PHST- 2022/12/28 06:00 [medline]
PHST- 2022/12/23 00:00 [pmc-release]
AID - 10/6/e003003 [pii]
AID - bmjdrc-2022-003003 [pii]
AID - 10.1136/bmjdrc-2022-003003 [doi]
PST - ppublish
SO  - BMJ Open Diabetes Res Care. 2022 Dec;10(6):e003003. doi: 
      10.1136/bmjdrc-2022-003003.