PMID- 36564376
OWN - NLM
STAT- MEDLINE
DCOM- 20221227
LR  - 20230301
IS  - 2044-4052 (Electronic)
IS  - 2044-4052 (Linking)
VI  - 12
IP  - 1
DP  - 2022 Dec 23
TI  - The effect of aging on glucose metabolism improvement after Roux-en-Y gastric 
      bypass in type 2 diabetes rats.
PG  - 51
LID - 10.1038/s41387-022-00229-9 [doi]
LID - 51
AB  - BACKGROUND: This study aimed to investigate the effect of aging on glucose 
      metabolism improvement after Roux-en-Y gastric bypass (RYGB) in rat models with 
      type 2 diabetes mellitus (T2DM). METHODS: Twenty aged Goto-Kakizaki rats were 
      randomly assigned into RYGB-A group and sham RYGB (SR-A) group, and 10 adult 
      Goto-Kakizaki rats also accept RYGB procedures (RYGB-Y). Glucose metabolism, 
      resting energy expenditure (REE), glucagon-like peptide-1 (GLP-1) and total bile 
      acid level were measured. RESULTS: RYGB could significantly improve glucose 
      metabolism in aged diabetic rats. The fasting blood glucose level in the RYGB-A 
      group decreased from 15.8 +/- 1.1 mmol/l before surgery to 12.3 +/- 1.5 mmol/l 16 
      weeks after surgery (P < 0.01), and the AUC(OGTT) value decreased from 
      2603.9 +/- 155.4 (mmol/l) min to 2299.9 +/- 252.8 (mmol/l) min (P = 0.08). The 
      decrease range of fasting blood glucose in the RYGB-A group was less than that in 
      the RYGB-Y group (20.5% +/- 6.5% vs. 40.6% +/- 10.6%, P < 0.01), so is the decrease 
      range of AUC(OGTT) value (11.6% +/- 14.8% vs. 38.5% +/- 8.3%, P < 0.01). Moreover, at 
      the 16th postoperative week, the increase range of REE of the RYGB-A group was 
      lower than that of the RYGB-Y group (15.3% +/- 11.1% vs. 29.1% +/- 12.1%, P = 0.04). 
      The increased range of bile acid of the RYGB-A group was less than that of the 
      RYGB-Y group (80.2 +/- 59.3 % vs.212.3 +/- 139.0 %, P < 0.01). The GLP-1 level of the 
      RYGB-A group was less than that of the RYGB-Y group (12.8 +/- 3.9 pmol/L vs. 
      18.7 +/- 5.6 pmol/L, P = 0.02). There was no significant difference between the 
      RYGB-A group and the RYGB-Y group in the level of the triiodothyronine level. 
      CONCLUSIONS: RYGB could induce a glucose metabolism improvement in aged diabetic 
      rats, and aging might moderate the effect of RYGB.
CI  - (c) 2022. The Author(s).
FAU - Chen, Weijie
AU  - Chen W
AD  - Department of General Surgery, Peking Union Medical College Hospital, Chinese 
      Academy of Medical Sciences, Shuaifuyuan 1#, Beijing, 100730, PR China.
FAU - Yin, Haixin
AU  - Yin H
AD  - Department of General Surgery, Peking Union Medical College Hospital, Chinese 
      Academy of Medical Sciences, Shuaifuyuan 1#, Beijing, 100730, PR China.
FAU - Xiao, Jianchun
AU  - Xiao J
AD  - Department of General Surgery, Peking Union Medical College Hospital, Chinese 
      Academy of Medical Sciences, Shuaifuyuan 1#, Beijing, 100730, PR China.
FAU - Liu, Wei
AU  - Liu W
AD  - Department of General Surgery, Peking Union Medical College Hospital, Chinese 
      Academy of Medical Sciences, Shuaifuyuan 1#, Beijing, 100730, PR China.
FAU - Qu, Qiang
AU  - Qu Q
AD  - Department of General Surgery, Peking Union Medical College Hospital, Chinese 
      Academy of Medical Sciences, Shuaifuyuan 1#, Beijing, 100730, PR China.
FAU - Gong, Fengying
AU  - Gong F
AD  - Department of Endocrinology, Key Laboratory of Endocrinology of the Ministry of 
      Health, Peking Union Medical College Hospital, Chinese Academy of Medical 
      Sciences, Shuaifuyuan 1#, Beijing, 100730, PR China.
FAU - He, Xiaodong
AU  - He X
AUID- ORCID: 0000-0002-6682-2926
AD  - Department of General Surgery, Peking Union Medical College Hospital, Chinese 
      Academy of Medical Sciences, Shuaifuyuan 1#, Beijing, 100730, PR China. 
      hxdpumch@163.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20221223
PL  - England
TA  - Nutr Diabetes
JT  - Nutrition & diabetes
JID - 101566341
RN  - 0 (Blood Glucose)
RN  - 0 (Bile Acids and Salts)
RN  - 89750-14-1 (Glucagon-Like Peptide 1)
SB  - IM
MH  - Rats
MH  - Animals
MH  - *Gastric Bypass/methods
MH  - Blood Glucose/metabolism
MH  - *Diabetes Mellitus, Experimental/metabolism
MH  - *Diabetes Mellitus, Type 2
MH  - Bile Acids and Salts
MH  - Glucagon-Like Peptide 1
MH  - Aging
PMC - PMC9789110
COIS- The authors declare no competing interests.
EDAT- 2022/12/24 06:00
MHDA- 2022/12/28 06:00
PMCR- 2022/12/23
CRDT- 2022/12/23 23:15
PHST- 2021/09/27 00:00 [received]
PHST- 2022/12/14 00:00 [accepted]
PHST- 2022/12/01 00:00 [revised]
PHST- 2022/12/23 23:15 [entrez]
PHST- 2022/12/24 06:00 [pubmed]
PHST- 2022/12/28 06:00 [medline]
PHST- 2022/12/23 00:00 [pmc-release]
AID - 10.1038/s41387-022-00229-9 [pii]
AID - 229 [pii]
AID - 10.1038/s41387-022-00229-9 [doi]
PST - epublish
SO  - Nutr Diabetes. 2022 Dec 23;12(1):51. doi: 10.1038/s41387-022-00229-9.