PMID- 36564806
OWN - NLM
STAT- MEDLINE
DCOM- 20221227
LR  - 20230103
IS  - 1477-7827 (Electronic)
IS  - 1477-7827 (Linking)
VI  - 20
IP  - 1
DP  - 2022 Dec 23
TI  - Higher daytime systolic BP, prepregnancy BMI and an elevated sFlt-1/PlGF ratio 
      predict the development of hypertension in normotensive pregnant women.
PG  - 175
LID - 10.1186/s12958-022-01050-w [doi]
LID - 175
AB  - BACKGROUND: The risk of hypertensive disorders of pregnancy (HDP) varies in women 
      with gestational diabetes mellitus (GDM), depending on the degree of insulin 
      resistance and is also influenced by obesity. The aim of this study was to 
      evaluate clinical features, blood pressure (BP) profiles and inflammatory 
      markers, to identify patients with an elevated risk of developing HDP. METHODS: A 
      total of 146 normotensive pregnant women were studied. We analysed the 
      relationships of BP profiles detected by ambulatory blood pressure monitoring 
      (ABPM) with serum biomarkers and angiogenic factors and their association with 
      the development of HDP. RESULTS: Fourteen (9.6%) women developed HDP, of which 11 
      had GDM and 8 had obesity. Women with HDP had higher values of 24-h and daytime 
      systolic/diastolic BP (113/69 vs. 104/64; 115/72 vs. 106/66 mmHg, respectively; 
      p <  0.05). Higher levels of leptin (10.97 +/- 0.82 vs. 10.2 +/- 1.11; p = 0.018) 
      andmonocyte chemoattractant protein-1 (MCP-1) (5.24 +/- 0.60 vs. 4.9 +/- 0.55; 
      p = 0.044) and a higher soluble fms-like tyrosine kinase-1/placental growth 
      factor (sFlt-1/PlGF) ratio (4.37 +/- 2.2 vs. 2.2 +/- 1.43; p = 0.003) were also 
      observed in the HDP patients. Multivariate analysis showed that a higher 
      sFlt-1/PlGF ratio was associated with an increased risk of developing HDP 
      [OR = 2.02; IC 95%: 1.35-3.05]. Furthermore, higher daytime systolic BP 
      [OR = 1.27; IC 95% 1.00-1.26] and prepregnancy body mass index (BMI) [OR = 1.14; 
      IC 95%: 1.01-1.30] significantly increased the risk of developing HDP. 
      CONCLUSIONS: Higher daytime systolic BP values, prepregnancy BMI and the 
      sFlt-1/PlGF ratio are useful for identifying normotensive pregnant women with an 
      increased risk of developing HDP.
CI  - (c) 2022. The Author(s).
FAU - Lara-Barea, Almudena
AU  - Lara-Barea A
AD  - Department of Endocrinology and Nutrition, Puerta del Mar Hospital, 11009, Cadiz, 
      Spain. almlarbar@gmail.com.
AD  - Biomedical Research and Innovation Institute of Cadiz (INiBICA), Puerta del Mar 
      Hospital, 11009, Cadiz, Spain. almlarbar@gmail.com.
FAU - Sanchez-Lechuga, Begona
AU  - Sanchez-Lechuga B
AD  - Department of Endocrinology and Nutrition, Puerta del Mar Hospital, 11009, Cadiz, 
      Spain.
FAU - Aguilar-Diosdado, Manuel
AU  - Aguilar-Diosdado M
AD  - Department of Endocrinology and Nutrition, Puerta del Mar Hospital, 11009, Cadiz, 
      Spain.
AD  - Biomedical Research and Innovation Institute of Cadiz (INiBICA), Puerta del Mar 
      Hospital, 11009, Cadiz, Spain.
AD  - Department of Medicine, Cadiz University (UCA), 11003, Cadiz, Spain.
FAU - Lopez-Tinoco, Cristina
AU  - Lopez-Tinoco C
AD  - Department of Endocrinology and Nutrition, Puerta del Mar Hospital, 11009, Cadiz, 
      Spain.
AD  - Biomedical Research and Innovation Institute of Cadiz (INiBICA), Puerta del Mar 
      Hospital, 11009, Cadiz, Spain.
AD  - Department of Medicine, Cadiz University (UCA), 11003, Cadiz, Spain.
LA  - eng
PT  - Journal Article
DEP - 20221223
PL  - England
TA  - Reprod Biol Endocrinol
JT  - Reproductive biology and endocrinology : RB&E
JID - 101153627
RN  - 144589-93-5 (Placenta Growth Factor)
RN  - 0 (Biomarkers)
RN  - EC 2.7.10.1 (Vascular Endothelial Growth Factor Receptor-1)
SB  - IM
MH  - Female
MH  - Pregnancy
MH  - Humans
MH  - Male
MH  - Blood Pressure
MH  - Pregnant Women
MH  - Body Mass Index
MH  - Blood Pressure Monitoring, Ambulatory
MH  - Placenta Growth Factor
MH  - *Hypertension
MH  - Biomarkers
MH  - Obesity/complications/diagnosis
MH  - Vascular Endothelial Growth Factor Receptor-1
MH  - *Pre-Eclampsia
PMC - PMC9783759
OTO - NOTNLM
OT  - Ambulatory blood pressure monitoring
OT  - Cytokine profile; sFlt-1/PIGF ratio
OT  - Hypertensive disorders of pregnancy
OT  - Predictor
COIS- The authors declare that they have no competing interests.
EDAT- 2022/12/24 06:00
MHDA- 2022/12/28 06:00
PMCR- 2022/12/23
CRDT- 2022/12/23 23:52
PHST- 2022/08/09 00:00 [received]
PHST- 2022/12/13 00:00 [accepted]
PHST- 2022/12/23 23:52 [entrez]
PHST- 2022/12/24 06:00 [pubmed]
PHST- 2022/12/28 06:00 [medline]
PHST- 2022/12/23 00:00 [pmc-release]
AID - 10.1186/s12958-022-01050-w [pii]
AID - 1050 [pii]
AID - 10.1186/s12958-022-01050-w [doi]
PST - epublish
SO  - Reprod Biol Endocrinol. 2022 Dec 23;20(1):175. doi: 10.1186/s12958-022-01050-w.