PMID- 36565071
OWN - NLM
STAT- MEDLINE
DCOM- 20230228
LR  - 20230228
IS  - 1878-6448 (Electronic)
IS  - 1053-8135 (Linking)
VI  - 52
IP  - 2
DP  - 2023
TI  - Derivation of a minimal clinically important difference score for the WHODAS 2.0 
      in mild traumatic brain injury.
PG  - 249-257
LID - 10.3233/NRE-220004 [doi]
AB  - BACKGROUND: Mild traumatic brain injury (mTBI) treatment research is hindered by 
      lack of clinically meaningful and responsive outcome measures. One promising 
      measure is the World Health Organisation Disability Assessment Schedule 2.0 
      (WHODAS 2.0), although minimal clinically important differences (MCID) for have 
      not been established. OBJECTIVE: To estimate MCID for the WHODAS 2.0 for mTBI. 
      METHODS: We analysed two prospectively collected mTBI datasets (n = 225) 
      attending adult outpatient clinics in British Columbia, Canada. Participants 
      completed the 12-item WHODAS 2.0, Patient Global Impression of Change scale, and 
      Rivermead Post-Concussion Symptoms Questionnaire. We used anchor- and 
      distribution-based methods to explore MCIDs in WHODAS 2.0 scores. RESULTS: For 
      Study 1 (n = 131), the anchor and distribution-based approaches produced minimal 
      change estimates ranging from 1.3 to 2.8 interval scores. For Study 2 (n = 94), 
      the anchor and distribution-based approaches produced minimal change estimates 
      from 2.2 to 3.2 interval scores. For certain subgroups based on age, sex, and 
      post-concussion severity, minimal change estimates were slightly higher. 
      CONCLUSION: An MCID of 3.5 interval WHODAS 2.0 points would conservatively 
      capture meaningful change in adults of varying age, sex, and post-concussion 
      symptom severity. Such a uniform metric will assist future mTBI intervention 
      studies to improve standards of care and evaluation of outcomes.
FAU - Snell, Deborah L
AU  - Snell DL
AD  - Department of Orthopaedic Surgery and Musculoskeletal Medicine, University of 
      Otago Christchurch, Christchurch, New Zealand.
FAU - Silverberg, Noah D
AU  - Silverberg ND
AD  - Department of Psychology, University of British Columbia, Vancouver, BC, Canada.
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - NeuroRehabilitation
JT  - NeuroRehabilitation
JID - 9113791
SB  - IM
MH  - Adult
MH  - Humans
MH  - *Brain Concussion
MH  - Minimal Clinically Important Difference
MH  - *Post-Concussion Syndrome
MH  - Canada
OTO - NOTNLM
OT  - MCID
OT  - WHODAS 2.0
OT  - mTBI
OT  - mild traumatic brain injury
EDAT- 2022/12/25 06:00
MHDA- 2023/03/03 06:00
CRDT- 2022/12/24 04:22
PHST- 2022/12/25 06:00 [pubmed]
PHST- 2023/03/03 06:00 [medline]
PHST- 2022/12/24 04:22 [entrez]
AID - NRE220004 [pii]
AID - 10.3233/NRE-220004 [doi]
PST - ppublish
SO  - NeuroRehabilitation. 2023;52(2):249-257. doi: 10.3233/NRE-220004.