PMID- 36565569
OWN - NLM
STAT- MEDLINE
DCOM- 20230120
LR  - 20230323
IS  - 1879-0046 (Electronic)
IS  - 0376-8716 (Linking)
VI  - 243
DP  - 2023 Feb 1
TI  - Brain recovery of the NAc fibers and prediction of craving changes in person with 
      heroin addiction: A longitudinal study.
PG  - 109749
LID - S0376-8716(22)00486-0 [pii]
LID - 10.1016/j.drugalcdep.2022.109749 [doi]
AB  - BACKGROUND: Progress have been made in brain function recovery after long-term 
      abstinence in person with heroin addiction (PHA). However, less is known about 
      whether the nucleus accumbens (NAc) white matter pathways can recover in PHA by 
      prolonged abstinence. METHODS: Forty-two PHA and Thirty-nine age- and gender- 
      matched healthy controls (HCs) were recruited. Two MRI scans were obtained at 
      baseline (PHA1) and 8-month follow-up (PHA2). We employed tractography 
      atlas-based analysis (TABS) method to investigate fractional anisotropy (FA) 
      changes in NAc fiber tracts (i.e., Insula-NAc, ventral tegmental area (VTA)-NAc, 
      medial prefrontal cortex (MPFC)-NAc) in PHA. A partial least square regression 
      (PLSR) analysis was carried to explore whether FA of NAc fiber tracts can predict 
      longitudinal craving changes. RESULTS: Relative to HCs, lower FA was found in the 
      right Insula-NAc and VTA-NAc fiber tracts in PHA1, and PHA2 showed increased FA 
      values in these tracts compared with PHA1. Furthermore, changes of FA of NAc 
      fiber tracts can predict longitudinal craving changes (r = 0.51). Additionally, 
      craving changes can also be predicted from FA changes in the left Insula-NAc 
      (r = 0.601) and VTA-NAc (r = 0.384) fiber alone. CONCLUSIONS: Results indicated 
      that the right Insula-NAc and VTA-NAc fiber tracts are potential biomarkers for 
      brain recovery. Prediction of craving changes highlighted the utility of 
      structural markers to inform clinical decision-making of treatment for PHA.
CI  - Copyright (c) 2022 Elsevier B.V. All rights reserved.
FAU - Lu, Ling
AU  - Lu L
AD  - Center for Brain Imaging, School of Life Science and Technology, Xidian 
      University, Xi'an, Shaanxi 710126, China; Engineering Research Center of 
      Molecular and Neuro Imaging Ministry of Education, Xi'an, Shaanxi, 710071, China.
FAU - Yang, Wenhan
AU  - Yang W
AD  - Department of Radiology, Second Xiangya Hospital of Central South University, 
      Changsha, China.
FAU - Zhao, Desheng
AU  - Zhao D
AD  - Center for Brain Imaging, School of Life Science and Technology, Xidian 
      University, Xi'an, Shaanxi 710126, China; Engineering Research Center of 
      Molecular and Neuro Imaging Ministry of Education, Xi'an, Shaanxi, 710071, China.
FAU - Wen, Xinwen
AU  - Wen X
AD  - Center for Brain Imaging, School of Life Science and Technology, Xidian 
      University, Xi'an, Shaanxi 710126, China; Engineering Research Center of 
      Molecular and Neuro Imaging Ministry of Education, Xi'an, Shaanxi, 710071, China.
FAU - Liu, Jun
AU  - Liu J
AD  - Department of Radiology, Second Xiangya Hospital of Central South University, 
      Changsha, China. Electronic address: junliu123@csu.edu.cn.
FAU - Liu, Jixin
AU  - Liu J
AD  - Center for Brain Imaging, School of Life Science and Technology, Xidian 
      University, Xi'an, Shaanxi 710126, China; Engineering Research Center of 
      Molecular and Neuro Imaging Ministry of Education, Xi'an, Shaanxi, 710071, China. 
      Electronic address: liujixin@xidian.edu.cn.
FAU - Yuan, Kai
AU  - Yuan K
AD  - Center for Brain Imaging, School of Life Science and Technology, Xidian 
      University, Xi'an, Shaanxi 710126, China; Engineering Research Center of 
      Molecular and Neuro Imaging Ministry of Education, Xi'an, Shaanxi, 710071, China; 
      International Joint Research Center for Advanced Medical Imaging and Intelligent 
      Diagnosis and Treatment & Xi'an Key Laboratory of Intelligent Sensing and 
      Regulation of trans-Scale Life Information, School of Life Science and 
      Technology, Xidian University, Xi'an, Shaanxi 710126, China; Information 
      Processing Laboratory, School of Information Engineering, Inner Mongolia 
      University of Science and Technology, Baotou, Inner Mongolia, 014010, China. 
      Electronic address: kyuan@xidian.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20221219
PL  - Ireland
TA  - Drug Alcohol Depend
JT  - Drug and alcohol dependence
JID - 7513587
SB  - IM
MH  - Humans
MH  - *Heroin Dependence
MH  - Craving
MH  - Longitudinal Studies
MH  - Brain/diagnostic imaging
MH  - Nucleus Accumbens
OTO - NOTNLM
OT  - Craving
OT  - Fiber tracts
OT  - Heroin
OT  - Nucleus accumbens
OT  - Prediction
OT  - Recovery
COIS- Conflict of Interest All authors declare that they have no conflict of interest.
EDAT- 2022/12/25 06:00
MHDA- 2023/01/21 06:00
CRDT- 2022/12/24 18:14
PHST- 2022/08/17 00:00 [received]
PHST- 2022/11/14 00:00 [revised]
PHST- 2022/12/07 00:00 [accepted]
PHST- 2022/12/25 06:00 [pubmed]
PHST- 2023/01/21 06:00 [medline]
PHST- 2022/12/24 18:14 [entrez]
AID - S0376-8716(22)00486-0 [pii]
AID - 10.1016/j.drugalcdep.2022.109749 [doi]
PST - ppublish
SO  - Drug Alcohol Depend. 2023 Feb 1;243:109749. doi: 
      10.1016/j.drugalcdep.2022.109749. Epub 2022 Dec 19.