PMID- 36567395
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230706
IS  - 2193-8261 (Print)
IS  - 2193-6544 (Electronic)
IS  - 2193-6544 (Linking)
VI  - 12
IP  - 1
DP  - 2023 Mar
TI  - Comparative Outcomes of TAVR in Mixed Aortic Valve Disease and Aortic Stenosis: A 
      Meta-analysis.
PG  - 143-157
LID - 10.1007/s40119-022-00293-3 [doi]
AB  - INTRODUCTION: Transcatheter aortic valve replacement (TAVR) has become a suitable 
      alternative to surgical aortic valve replacement (SAVR) for the treatment of 
      symptomatic severe aortic stenosis (AS). A high proportion of patients with AS 
      have mixed aortic valve disease (MAVD) with mild or more concurrent aortic 
      regurgitation (AR). Differential outcomes of TAVR among patients with AS and MAVD 
      have not been well characterized. We compared 1-year mortalities following TAVR 
      among patients with MAVD and AS. METHODS: We conducted a meta-analysis of studies 
      published in PubMed/Medline. The primary outcome was 1-year all-cause mortality 
      following TAVR among patients with MAVD vs. AS. Secondary endpoints were: (1) 
      incidence of AR within 30 days following TAVR (post TAVR AR); and (2) 1-year 
      all-cause mortality within each group stratified according to severity of post 
      TAVR AR. RESULTS: Nine studies involving 9505 participants were included in the 
      analysis. At 1 year following TAVR, mortality was lower in MAVD than in AS; HR 
      0.89, 95% CI 0.81-0.98. The mortality advantage increased when pre-TAVR AR was 
      moderate or more; HR 0.84, 95% CI 0.72-0.99. The mortality advantage was 
      attenuated after correction for publication bias. There was a higher risk of post 
      TAVR AR in the MAVD group; OR 1.51, 95% CI 1.20-1.90 but the impact on mortality 
      of moderate vs. mild post TAVR AR was greater among patients with AS than in 
      patients with MAVD HR 1.67 95% CI 0.89-3.14 vs. 0.93 95% CI 0.47-1.85. 
      CONCLUSIONS: Patients with MAVD have similar or improved survival 1 year after 
      TAVR compared to those with AS.
CI  - (c) 2022. The Author(s).
FAU - Ugwu, Justin K
AU  - Ugwu JK
AD  - Department of Cardiovascular Medicine, MercyOne Des Moines Medical Center, 1111 
      6Th Ave, Des Moines, IA, 50314, United States of America. 
      Email-ugwujustin@yahoo.com.
FAU - Kandah, Daniel R
AU  - Kandah DR
AD  - Internal Medicine Residency, MercyOne Des Moines Medical Center, Des Moines, IA, 
      United States of America.
FAU - Ndulue, Jideofor K
AU  - Ndulue JK
AD  - Providence Medical Group, Chehalis Family Medicine, Chehalis, WA, United States 
      of America.
FAU - Ebiem, Okechukwu P
AU  - Ebiem OP
AD  - Department of Hospital Medicine, Miami Valley Hospital, Dayton, OH, United States 
      of America.
FAU - Ugwu-Erugo, Judith N
AU  - Ugwu-Erugo JN
AD  - Ebonyi State University Teaching Hospital, Abakaliki, Nigeria.
FAU - Hamilton, Russell
AU  - Hamilton R
AD  - Department of Cardiovascular Medicine, MercyOne Des Moines Medical Center, 1111 
      6Th Ave, Des Moines, IA, 50314, United States of America.
FAU - Osei, Kofi
AU  - Osei K
AD  - Department of Cardiovascular Medicine, MercyOne Des Moines Medical Center, 1111 
      6Th Ave, Des Moines, IA, 50314, United States of America.
FAU - Taskesen, Tuncay
AU  - Taskesen T
AD  - Department of Cardiovascular Medicine, MercyOne Des Moines Medical Center, 1111 
      6Th Ave, Des Moines, IA, 50314, United States of America.
FAU - Shivapour, Daniel M
AU  - Shivapour DM
AD  - Department of Cardiovascular Medicine, MercyOne Des Moines Medical Center, 1111 
      6Th Ave, Des Moines, IA, 50314, United States of America.
FAU - Chawla, Atul
AU  - Chawla A
AD  - Department of Cardiovascular Medicine, MercyOne Des Moines Medical Center, 1111 
      6Th Ave, Des Moines, IA, 50314, United States of America.
FAU - Marcus, Richard H
AU  - Marcus RH
AD  - Department of Cardiovascular Medicine, MercyOne Des Moines Medical Center, 1111 
      6Th Ave, Des Moines, IA, 50314, United States of America.
LA  - eng
PT  - Journal Article
DEP - 20221225
PL  - England
TA  - Cardiol Ther
JT  - Cardiology and therapy
JID - 101634495
PMC - PMC9986165
OTO - NOTNLM
OT  - Aortic regurgitation
OT  - Mixed aortic valve disease
OT  - Pure aortic stenosis
OT  - Transcatheter aortic valve replacement
EDAT- 2022/12/26 06:00
MHDA- 2022/12/26 06:01
PMCR- 2022/12/25
CRDT- 2022/12/25 23:19
PHST- 2022/10/04 00:00 [received]
PHST- 2022/11/28 00:00 [accepted]
PHST- 2022/12/26 06:00 [pubmed]
PHST- 2022/12/26 06:01 [medline]
PHST- 2022/12/25 23:19 [entrez]
PHST- 2022/12/25 00:00 [pmc-release]
AID - 10.1007/s40119-022-00293-3 [pii]
AID - 293 [pii]
AID - 10.1007/s40119-022-00293-3 [doi]
PST - ppublish
SO  - Cardiol Ther. 2023 Mar;12(1):143-157. doi: 10.1007/s40119-022-00293-3. Epub 2022 
      Dec 25.