PMID- 36567492
OWN - NLM
STAT- MEDLINE
DCOM- 20230313
LR  - 20230313
IS  - 1442-9071 (Electronic)
IS  - 1442-6404 (Linking)
VI  - 51
IP  - 2
DP  - 2023 Mar
TI  - Spectral-domain optical coherence tomography biomarkers in vitreoretinal 
      lymphoma.
PG  - 144-153
LID - 10.1111/ceo.14197 [doi]
AB  - BACKGROUND: Although early detection is critical, diagnosing vitreoretinal 
      lymphoma (VRL) remains difficult. We sought to assess the potential diagnostic 
      value of spectral-domain optical coherence tomography (SD-OCT) in VRL. METHODS: 
      We reviewed the clinical records and pre-treatment SD-OCT images of 
      biopsy-confirmed VRL and uveitis patients, with primary involvement of the 
      sub-retinal pigment epithelium (RPE) and the outer retina, including acute 
      syphilitic posterior placoid chorioretinitis (ASPPC), chronic stage sympathetic 
      ophthalmitis (SO), and idiopathic multifocal choroiditis (MFC). RESULTS: We 
      included 45 eyes of 45 VRL patients and 40 eyes of 40 uveitis patients (17 ASPPC 
      eyes, eight chronic SO eyes, and 15 MFC eyes). On SD-OCT, lymphoma cell 
      infiltration was observed in various retinal layers, most commonly in the sub-RPE 
      (80%) and sub-retinal space (62%). Highly sensitive features for VRL as compared 
      to uveitis included vitreous cells (93%), focal hyper-reflective sub-retinal 
      infiltration (51%), and diffuse RPE elevations (56%). The features strongly 
      specific for VRL included preretinal deposits (92.5%), intra-retinal infiltration 
      (except the incomplete vertical hyper-reflective type, 100%), banded 
      hyper-reflective sub-retinal infiltration (90%), and confluent RPE detachments 
      (100%). We identified an approach to VRL diagnosis based on these SD-OCT 
      findings: (1) two highly sensitive features plus one strongly specific feature; 
      or (2) one highly sensitive feature plus two strongly specific features, 
      demonstrated a sensitivity of 80% and specificity of 95% for VRL. CONCLUSIONS: 
      The SD-OCT may enable the detection of detailed lymphoma infiltration 
      characteristics and provide significant supplemental value for VRL diagnosis, 
      particularly when combining highly sensitive and specific VRL-associated SD-OCT 
      features.
CI  - (c) 2022 Royal Australian and New Zealand College of Ophthalmologists.
FAU - Guan, Wenxue
AU  - Guan W
AUID- ORCID: 0000-0002-8412-8479
AD  - Department of Ophthalmology, Beijing Tongren Hospital, Capital Medical 
      University, Beijing, China.
FAU - Xiao, Yuanyuan
AU  - Xiao Y
AD  - Department of Ophthalmology, Beijing Tongren Hospital, Capital Medical 
      University, Beijing, China.
FAU - Zhao, Huiying
AU  - Zhao H
AD  - Department of Ophthalmology, Beijing Tongren Hospital, Capital Medical 
      University, Beijing, China.
AD  - Department of Ophthalmology, Beijing Geriatric Hospital, Beijing, China.
FAU - Hu, Feng
AU  - Hu F
AD  - Department of Ophthalmology, Beijing Tongren Hospital, Capital Medical 
      University, Beijing, China.
FAU - Chen, Chunli
AU  - Chen C
AD  - Department of Ophthalmology, Beijing Tongren Hospital, Capital Medical 
      University, Beijing, China.
FAU - Peng, Xiaoyan
AU  - Peng X
AUID- ORCID: 0000-0002-4275-6856
AD  - Department of Ophthalmology, Beijing Tongren Hospital, Capital Medical 
      University, Beijing, China.
LA  - eng
GR  - 2019005/Key Research Program of the Beijing Institute of Ophthalmology/
PT  - Journal Article
PT  - Review
DEP - 20230104
PL  - Australia
TA  - Clin Exp Ophthalmol
JT  - Clinical & experimental ophthalmology
JID - 100896531
SB  - IM
CIN - Clin Exp Ophthalmol. 2023 Mar;51(2):107-109. PMID: 36789671
MH  - Humans
MH  - Tomography, Optical Coherence/methods
MH  - *Retinal Neoplasms/drug therapy
MH  - Vitreous Body/diagnostic imaging/pathology
MH  - Retina/pathology
MH  - *Chorioretinitis/drug therapy
MH  - *Eye Neoplasms/pathology
MH  - *Lymphoma/diagnosis
MH  - *Syphilis
MH  - Retrospective Studies
MH  - Fluorescein Angiography
OTO - NOTNLM
OT  - diagnosis
OT  - intra-ocular lymphoma
OT  - optical coherence tomography
OT  - uveitis
EDAT- 2022/12/27 06:00
MHDA- 2023/03/14 06:00
CRDT- 2022/12/26 00:53
PHST- 2022/12/13 00:00 [revised]
PHST- 2022/08/31 00:00 [received]
PHST- 2022/12/18 00:00 [accepted]
PHST- 2022/12/27 06:00 [pubmed]
PHST- 2023/03/14 06:00 [medline]
PHST- 2022/12/26 00:53 [entrez]
AID - 10.1111/ceo.14197 [doi]
PST - ppublish
SO  - Clin Exp Ophthalmol. 2023 Mar;51(2):144-153. doi: 10.1111/ceo.14197. Epub 2023 
      Jan 4.