PMID- 36568875
OWN - NLM
STAT- MEDLINE
DCOM- 20221227
LR  - 20230103
IS  - 1752-8976 (Electronic)
IS  - 1470-3203 (Print)
IS  - 1470-3203 (Linking)
VI  - 2022
DP  - 2022
TI  - Fibrinogen-to-Albumin Ratio Predicts Postcontrast Acute Kidney Injury in Patients 
      with Non-ST Elevation Acute Coronary Syndrome after Implantation of Drug-Eluting 
      Stents.
PG  - 9833509
LID - 10.1155/2022/9833509 [doi]
LID - 9833509
AB  - BACKGROUND: Postcontrast acute kidney injury (PC-AKI) is an adverse reaction to 
      iodinated contrast agents. In this study, we investigated the use of 
      fibrinogen-to-albumin ratio (FAR) as a novel inflammatory marker to track the 
      development and progression of PC-AKI in patients with non-ST elevation acute 
      coronary syndrome (NSTE-ACS) after the implantation of drug-eluting stents 
      (DESs). METHODS: A total of 872 patients with NSTE-ACS were enrolled in this 
      study. PC-AKI was identified when serum creatinine (SCr) levels increased 
      >26.5 mol/L (0.3 mg/dL) or was 1.5 times the baseline level within 48-72 h of 
      exposure to an iodinated contrast agent. The effects of different variables on 
      PC-AKI were evaluated using univariate regression analysis. Multivariate logistic 
      regression analysis was used to determine the independent predictors of PC-AKI. 
      The predictive value of FAR was assessed by estimating the area under the 
      receiver operating characteristic (ROC) curve. RESULTS: In total, 114 (13.1%) 
      patients developed PC-AKI. The patients with PC-AKI had lower albumin levels 
      (40.5 +/- 3.4 vs. 39.0 +/- 3.5, P < 0.001), higher fibrinogen levels (3.7 +/- 0.6 vs. 
      4.1 +/- 0.5, P < 0.001), and higher FAR levels (9.2 +/- 1.7 vs. 10.5 +/- 1.7, P < 
      0.001) than those with non-PC-AKI. There were no significant differences in the 
      preoperative SCr levels between the two groups. After adjusting for confounding 
      factors, FAR was found to be an independent predictor of PC-AKI (OR = 1.478, 95% 
      CI = 1.298-1.684, P < 0.001). ROC analysis revealed that for PC-AKI prediction, 
      the area under the curve for FAR was 0.702. The optimum cut-off value of FAR was 
      10.0, with a sensitivity of 64.9% and a specificity of 69.8%. Moreover, FAR had a 
      higher predictive value for PC-AKI than the Mehran score (0.702 vs. 0.645). 
      CONCLUSION: Our study showed that elevated preoperative FAR was closely 
      associated with the development of PC-AKI in patients with NSTE-ACS after 
      implantation of DESs. Therefore, it may be worth monitoring FAR as a guide for 
      using preventive measures to avoid the development of PC-AKI.
CI  - Copyright (c) 2022 Yong Qiao et al.
FAU - Qiao, Yong
AU  - Qiao Y
AUID- ORCID: 0000-0003-1063-8967
AD  - Department of Cardiology, Zhongda Hospital, Southeast University, Nanjing, 
      Jiangsu, China.
FAU - Li, Mingkang
AU  - Li M
AUID- ORCID: 0000-0003-1329-0230
AD  - Department of Cardiology, Zhongda Hospital, Southeast University, Nanjing, 
      Jiangsu, China.
FAU - Li, Linqing
AU  - Li L
AUID- ORCID: 0000-0002-4757-3442
AD  - Department of Cardiology, Zhongda Hospital, Southeast University, Nanjing, 
      Jiangsu, China.
FAU - Tang, Chengchun
AU  - Tang C
AUID- ORCID: 0000-0003-3767-3551
AD  - Department of Cardiology, Zhongda Hospital, Southeast University, Nanjing, 
      Jiangsu, China.
LA  - eng
PT  - Journal Article
DEP - 20221123
PL  - England
TA  - J Renin Angiotensin Aldosterone Syst
JT  - Journal of the renin-angiotensin-aldosterone system : JRAAS
JID - 100971636
RN  - 0 (Contrast Media)
RN  - 9001-32-5 (Fibrinogen)
RN  - 0 (Albumins)
SB  - IM
MH  - Humans
MH  - *Acute Coronary Syndrome/chemically induced
MH  - *Drug-Eluting Stents
MH  - Risk Factors
MH  - Contrast Media/adverse effects
MH  - *Acute Kidney Injury/chemically induced
MH  - Fibrinogen
MH  - Albumins
MH  - Retrospective Studies
PMC - PMC9711978
COIS- The authors declare that they have no known competing financial interests or 
      personal relationships that could have appeared to influence the work reported in 
      this paper.
EDAT- 2022/12/27 06:00
MHDA- 2022/12/28 06:00
PMCR- 2022/11/23
CRDT- 2022/12/26 04:01
PHST- 2022/07/09 00:00 [received]
PHST- 2022/11/04 00:00 [revised]
PHST- 2022/11/05 00:00 [accepted]
PHST- 2022/12/26 04:01 [entrez]
PHST- 2022/12/27 06:00 [pubmed]
PHST- 2022/12/28 06:00 [medline]
PHST- 2022/11/23 00:00 [pmc-release]
AID - 10.1155/2022/9833509 [doi]
PST - epublish
SO  - J Renin Angiotensin Aldosterone Syst. 2022 Nov 23;2022:9833509. doi: 
      10.1155/2022/9833509. eCollection 2022.