PMID- 36571426
OWN - NLM
STAT- MEDLINE
DCOM- 20230124
LR  - 20230203
IS  - 2146-3131 (Electronic)
IS  - 2146-3123 (Print)
IS  - 2146-3123 (Linking)
VI  - 40
IP  - 1
DP  - 2023 Jan 23
TI  - Silencing SOX11 Alleviates Allergic Rhinitis by Inhibiting Epithelial-Derived 
      Cytokines.
PG  - 57-65
LID - 10.4274/balkanmedj.galenos.2022.2022-9-31 [doi]
AB  - BACKGROUND: Allergic rhinitis is a chronic inflammatory disease of the nasal 
      mucosa affecting the quality of life of patients. SRY-box transcription factor 11 
      (SOX11) was reported to play important roles in inflammatory responses, but its 
      role in AR is poorly understood. AIMS: To explore the role of SOX11 in the 
      development of allergic rhinitis. STUDY DESIGN: Cell culture and animal study. 
      METHODS: An in vivo murine allergic rhinitis model was established using 
      ovalbumin treatment in female mice. Interleukin-13-stimulated human nasal mucosa 
      epithelial cells were used for in vitro studies. Expression levels of SOX11, 
      epithelial-derived cytokines, and mucin were determined in both modesls. RESULTS: 
      SOX11 was highly expressed in allergic rhinitis mice. Allergy symptoms, serum 
      ovalbumin-specific IgE, histamine, eosinophils, goblet cells, and type 2 cytokine 
      secretion were increased in ovalbumin-treated mice. Furthermore, allergic 
      rhinitis mice exhibited overproduction of epithelial-derived cytokines (thymic 
      stromal lymphopoietin, interleukin-25, interleukin-33), C-C motif chemokine 
      ligand 26 (CCL26), and mucin 5 AC (MUC5AC). Silencing SOX11 alleviated the 
      behavioral symptoms and upregulation of epithelial-derived cytokines, CCL26, and 
      MUC5AC. In human nasal mucosa epithelial cells, interleukin-13 enhanced SOX11 
      expression in a time-dependent manner, and signal transducer and activator of 
      transcription 6 (STAT6) was involved in the interleukin-13-mediated expression of 
      SOX11 by regulating transcription. Knockdown of SOX11 reduced epithelial-derived 
      cytokine expression and MUC5AC levels in interleukin-13-treated human nasal 
      mucosa epithelial cells. CONCLUSION: SOX11 plays a critical role in allergic 
      rhinitis development by regulating epithelial-derived cytokines and might be a 
      new therapeutic target for allergic rhinitis.
FAU - Jiang, Li
AU  - Jiang L
AUID- ORCID: 0000-0001-7397-9967
AD  - Department of Otolaryngology Head and Neck Surgery, The First Affiliated Hospital 
      of Harbin Medical University, Heilongjiang, China
FAU - Wang, Chunrui
AU  - Wang C
AUID- ORCID: 0000-0003-3168-1956
AD  - Department of Otolaryngology Head and Neck Surgery, The First Affiliated Hospital 
      of Harbin Medical University, Heilongjiang, China
FAU - Zhao, Rui
AU  - Zhao R
AUID- ORCID: 0000-0002-6602-6583
AD  - Department of Otolaryngology Head and Neck Surgery, The Second Affiliated 
      Hospital of Harbin Medical University, Heilongjiang, China
FAU - Cao, Jing
AU  - Cao J
AUID- ORCID: 0000-0001-9304-3189
AD  - Department of Otolaryngology Head and Neck Surgery, The Second Affiliated 
      Hospital of Harbin Medical University, Heilongjiang, China
FAU - Liu, Yaohui
AU  - Liu Y
AUID- ORCID: 0000-0002-1377-6911
AD  - Department of Otolaryngology Head and Neck Surgery, The Second Affiliated 
      Hospital of Harbin Medical University, Heilongjiang, China
FAU - Tian, Linli
AU  - Tian L
AUID- ORCID: 0000-0002-8934-1607
AD  - Department of Otolaryngology Head and Neck Surgery, The Second Affiliated 
      Hospital of Harbin Medical University, Heilongjiang, China
FAU - Liu, Ming
AU  - Liu M
AUID- ORCID: 0000-0002-4098-6631
AD  - Department of Otolaryngology Head and Neck Surgery, The Second Affiliated 
      Hospital of Harbin Medical University, Heilongjiang, China
LA  - eng
PT  - Journal Article
DEP - 20221226
PL  - Turkey
TA  - Balkan Med J
JT  - Balkan medical journal
JID - 101571817
RN  - 0 (Cytokines)
RN  - 0 (Interleukin-13)
RN  - 9006-59-1 (Ovalbumin)
RN  - 0 (Mucins)
RN  - 0 (SOX11 protein, human)
RN  - 0 (SOXC Transcription Factors)
RN  - 0 (Sox11 protein, mouse)
SB  - IM
MH  - Humans
MH  - Female
MH  - Mice
MH  - Animals
MH  - *Cytokines/metabolism/therapeutic use
MH  - Interleukin-13/pharmacology/therapeutic use
MH  - Ovalbumin/pharmacology/therapeutic use
MH  - Quality of Life
MH  - *Rhinitis, Allergic
MH  - Mucins/therapeutic use
MH  - SOXC Transcription Factors
PMC - PMC9874254
COIS- Conflict of Interest: No conflict of interest was declared by the authors. 
      Funding: The authors declared that this study received no financial support.
EDAT- 2022/12/27 06:00
MHDA- 2023/01/25 06:00
PMCR- 2023/01/23
CRDT- 2022/12/26 08:15
PHST- 2022/12/26 08:15 [entrez]
PHST- 2022/12/27 06:00 [pubmed]
PHST- 2023/01/25 06:00 [medline]
PHST- 2023/01/23 00:00 [pmc-release]
AID - 58388 [pii]
AID - 10.4274/balkanmedj.galenos.2022.2022-9-31 [doi]
PST - ppublish
SO  - Balkan Med J. 2023 Jan 23;40(1):57-65. doi: 
      10.4274/balkanmedj.galenos.2022.2022-9-31. Epub 2022 Dec 26.